Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ Cells
Apoptosis is widely known to play a major role on diseases related to male infertility. Diseases of the male genital tract as defective spermatogenesis, decreased sperm motility, sperm DNA fragmentation, testicular torsion, varicocele and immunological infertility are strongly related to apoptotic c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2018.00065/full |
| _version_ | 1818158493193994240 |
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| author | Ignacio Bejarano Ana B. Rodríguez José A. Pariente |
| author_facet | Ignacio Bejarano Ana B. Rodríguez José A. Pariente |
| author_sort | Ignacio Bejarano |
| collection | DOAJ |
| description | Apoptosis is widely known to play a major role on diseases related to male infertility. Diseases of the male genital tract as defective spermatogenesis, decreased sperm motility, sperm DNA fragmentation, testicular torsion, varicocele and immunological infertility are strongly related to apoptotic cell death. Apoptosis must not be considered only as a fail on germ cell physiology or a secondary effect of certain pathologies and exogenous hazardous agents. Apoptosis orchestrates correct function and development of the male germ cell from the early embryonic stages of gonadal differentiation to the fertilization. In this review we have tried to address a reading frame of the main knowledge about apoptosis in male germ cell development. Focussing on mechanisms concerning cellular apoptosis, which are independent of exogenous stimuli, we aimed to highlight that apoptosis is a selective instrument that guarantees the delivery of genetic message to offspring. |
| first_indexed | 2024-12-11T15:30:58Z |
| format | Article |
| id | doaj.art-3202360493984a3ebeded5e09a585916 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-11T15:30:58Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-3202360493984a3ebeded5e09a5859162022-12-22T01:00:03ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2018-06-01610.3389/fcell.2018.00065382278Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ CellsIgnacio BejaranoAna B. RodríguezJosé A. ParienteApoptosis is widely known to play a major role on diseases related to male infertility. Diseases of the male genital tract as defective spermatogenesis, decreased sperm motility, sperm DNA fragmentation, testicular torsion, varicocele and immunological infertility are strongly related to apoptotic cell death. Apoptosis must not be considered only as a fail on germ cell physiology or a secondary effect of certain pathologies and exogenous hazardous agents. Apoptosis orchestrates correct function and development of the male germ cell from the early embryonic stages of gonadal differentiation to the fertilization. In this review we have tried to address a reading frame of the main knowledge about apoptosis in male germ cell development. Focussing on mechanisms concerning cellular apoptosis, which are independent of exogenous stimuli, we aimed to highlight that apoptosis is a selective instrument that guarantees the delivery of genetic message to offspring.https://www.frontiersin.org/article/10.3389/fcell.2018.00065/fullprimordial germ cellsgonocytesspermatogoniaapoptosisdifferentiation |
| spellingShingle | Ignacio Bejarano Ana B. Rodríguez José A. Pariente Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ Cells Frontiers in Cell and Developmental Biology primordial germ cells gonocytes spermatogonia apoptosis differentiation |
| title | Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ Cells |
| title_full | Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ Cells |
| title_fullStr | Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ Cells |
| title_full_unstemmed | Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ Cells |
| title_short | Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ Cells |
| title_sort | apoptosis is a demanding selective tool during the development of fetal male germ cells |
| topic | primordial germ cells gonocytes spermatogonia apoptosis differentiation |
| url | https://www.frontiersin.org/article/10.3389/fcell.2018.00065/full |
| work_keys_str_mv | AT ignaciobejarano apoptosisisademandingselectivetoolduringthedevelopmentoffetalmalegermcells AT anabrodriguez apoptosisisademandingselectivetoolduringthedevelopmentoffetalmalegermcells AT joseapariente apoptosisisademandingselectivetoolduringthedevelopmentoffetalmalegermcells |