Role of Haematological Markers in Predicting Short-term Outcome in Neonates with Birth Asphyxia
Introduction: Perinatal asphyxia is a major global cause of neurological morbidity and mortality in neonates. In a developing country with major over population crisis, a large number of deliveries occur in peripheral healthcare facilities and at home by trained and untrained birth attendants in...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Pvt. Ltd.
2019-01-01
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| Series: | Indian Journal of Neonatal Medicine and Research |
| Subjects: | |
| Online Access: | http://www.ijnmr.net/articles/PDF/2241/40269_CE[Ra1]_F(SHU)_PF1(AB_SHU)_PFA(SHU)_PN(SHU).pdf |
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| author | Sharath Keerthy Shankargouda Patil SS Kalyanshettar |
| author_facet | Sharath Keerthy Shankargouda Patil SS Kalyanshettar |
| author_sort | Sharath Keerthy |
| collection | DOAJ |
| description | Introduction: Perinatal asphyxia is a major global cause
of neurological morbidity and mortality in neonates. In a
developing country with major over population crisis, a large
number of deliveries occur in peripheral healthcare facilities
and at home by trained and untrained birth attendants in a
very minimal infrastructure. In these scenarios, an accurate
and reliable marker for birth asphyxia is needed for both
diagnostic as well as prognostic evaluation.
Aim: To study neonates with birth asphyxia in terms of
Nucleated RBC (NRBC) and Reticulocyte Count in cord
blood and/or neonatal venous blood and correlate it with the
short-term outcome (up to discharge).
Materials and Methods: A prospective observational
study conducted in Neonatal Intensive Care Unit (NICU) in
teaching hospital affiliated with medical college involving 125
term neonates with birth asphyxia. Cord blood/peripheral
venous blood collected within six hours of birth was used
for preparation of peripheral smear for evaluating NRBC
count and Reticulocyte count. Reticulocyte counts more
than 7% were considered high/positive and NRBC counts
more than 10/100 WBC’s were considered high/positive.
Duration of NICU stay more than five days was considered
significant among asphyxiated babies. Babies less than 37
weeks gestational age or with birth weight less than 1500
g, syndromic babies or with any congenital anomalies were
excluded.
Results: Both NRBC counts and Reticulocyte counts
were statistically significant with relation to duration of
NICU stay. NRBC counts were statistically significant with
relation to Hypoxic Ischemic Encephalopathy (HIE) staging,
even though Reticulocyte counts were higher in neonates
with higher staging of the disease it was statistically not
significant. Both NRBC counts and Reticulocyte counts
were statistically not significant with relation to neurological
outcome at discharge.
Conclusion: It can be concluded that NRBC count and
Reticulocyte count are simple markers for assessment
of severity and early outcomes of perinatal asphyxia and
duration of stay in NICU. |
| first_indexed | 2024-12-17T00:08:44Z |
| format | Article |
| id | doaj.art-3202cbd2f2c049569af3c6863bc18001 |
| institution | Directory Open Access Journal |
| issn | 2277-8527 2455-6890 |
| language | English |
| last_indexed | 2024-12-17T00:08:44Z |
| publishDate | 2019-01-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Neonatal Medicine and Research |
| spelling | doaj.art-3202cbd2f2c049569af3c6863bc180012022-12-21T22:10:53ZengJCDR Research and Publications Pvt. Ltd.Indian Journal of Neonatal Medicine and Research2277-85272455-68902019-01-0171PO01PO0410.7860/IJNMR/2019/40269.2241Role of Haematological Markers in Predicting Short-term Outcome in Neonates with Birth AsphyxiaSharath Keerthy0Shankargouda Patil1SS Kalyanshettar2Resident, Department of Paediatrics, BLDE (Deemed To Be University), Vijayapur, Karnataka, India.Professor and Head, Department of Paediatrics, Shri B M Patil medical college, BLDE (Deemed To Be University), Vijayapur, Karnataka, India.Professor, Department of Paediatrics, Shri BM Patil Medical College, BLDE (Deemed To Be University), Vijayapur, Karnataka, India.Introduction: Perinatal asphyxia is a major global cause of neurological morbidity and mortality in neonates. In a developing country with major over population crisis, a large number of deliveries occur in peripheral healthcare facilities and at home by trained and untrained birth attendants in a very minimal infrastructure. In these scenarios, an accurate and reliable marker for birth asphyxia is needed for both diagnostic as well as prognostic evaluation. Aim: To study neonates with birth asphyxia in terms of Nucleated RBC (NRBC) and Reticulocyte Count in cord blood and/or neonatal venous blood and correlate it with the short-term outcome (up to discharge). Materials and Methods: A prospective observational study conducted in Neonatal Intensive Care Unit (NICU) in teaching hospital affiliated with medical college involving 125 term neonates with birth asphyxia. Cord blood/peripheral venous blood collected within six hours of birth was used for preparation of peripheral smear for evaluating NRBC count and Reticulocyte count. Reticulocyte counts more than 7% were considered high/positive and NRBC counts more than 10/100 WBC’s were considered high/positive. Duration of NICU stay more than five days was considered significant among asphyxiated babies. Babies less than 37 weeks gestational age or with birth weight less than 1500 g, syndromic babies or with any congenital anomalies were excluded. Results: Both NRBC counts and Reticulocyte counts were statistically significant with relation to duration of NICU stay. NRBC counts were statistically significant with relation to Hypoxic Ischemic Encephalopathy (HIE) staging, even though Reticulocyte counts were higher in neonates with higher staging of the disease it was statistically not significant. Both NRBC counts and Reticulocyte counts were statistically not significant with relation to neurological outcome at discharge. Conclusion: It can be concluded that NRBC count and Reticulocyte count are simple markers for assessment of severity and early outcomes of perinatal asphyxia and duration of stay in NICU.http://www.ijnmr.net/articles/PDF/2241/40269_CE[Ra1]_F(SHU)_PF1(AB_SHU)_PFA(SHU)_PN(SHU).pdfasphyxia neonatorumhypoxia-ischemianucleated erythrocyte countreticulocyte count |
| spellingShingle | Sharath Keerthy Shankargouda Patil SS Kalyanshettar Role of Haematological Markers in Predicting Short-term Outcome in Neonates with Birth Asphyxia Indian Journal of Neonatal Medicine and Research asphyxia neonatorum hypoxia-ischemia nucleated erythrocyte count reticulocyte count |
| title | Role of Haematological Markers in Predicting Short-term Outcome in Neonates with Birth Asphyxia |
| title_full | Role of Haematological Markers in Predicting Short-term Outcome in Neonates with Birth Asphyxia |
| title_fullStr | Role of Haematological Markers in Predicting Short-term Outcome in Neonates with Birth Asphyxia |
| title_full_unstemmed | Role of Haematological Markers in Predicting Short-term Outcome in Neonates with Birth Asphyxia |
| title_short | Role of Haematological Markers in Predicting Short-term Outcome in Neonates with Birth Asphyxia |
| title_sort | role of haematological markers in predicting short term outcome in neonates with birth asphyxia |
| topic | asphyxia neonatorum hypoxia-ischemia nucleated erythrocyte count reticulocyte count |
| url | http://www.ijnmr.net/articles/PDF/2241/40269_CE[Ra1]_F(SHU)_PF1(AB_SHU)_PFA(SHU)_PN(SHU).pdf |
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