An intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component: A case report
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are a risk factor for the development of adenocarcinoma. However, the presence of a component of sarcomatoid carcinoma in the malignant tumor has rarely been described in the literature. A 30-year-old Chinese woman was admitted to our...
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| Format: | Article |
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Elsevier
2021-11-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043321006099 |
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| author | Chuanhang Zang, BA Shuai Li, BA Bo Chi, BA Shuai Chen, MA Zhexuan Ye, BA |
| author_facet | Chuanhang Zang, BA Shuai Li, BA Bo Chi, BA Shuai Chen, MA Zhexuan Ye, BA |
| author_sort | Chuanhang Zang, BA |
| collection | DOAJ |
| description | Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are a risk factor for the development of adenocarcinoma. However, the presence of a component of sarcomatoid carcinoma in the malignant tumor has rarely been described in the literature. A 30-year-old Chinese woman was admitted to our hospital with vague abdominal pain and a poor appetite for 2 months. Computed tomography revealed a huge, unilocular, solid-cystic mass in the pancreatic body, and tail. The patient underwent an en bloc resection of the distal pancreatic tumor with splenectomy and regional lymphadenectomy. Pathologic examination revealed an IPMN associated tubular adenocarcinoma containing a component of sarcomatoid (spindle-shaped cell) carcinoma. Immunohistochemical results revealed that the mononuclear spindle-shaped cells were positive for both pan-cytokeratin and vimentin. There was no evidence of perineural or vascular infiltration, lymph nodal metastasis, or positive surgical margins. The patient developed local recurrence 3 months after surgery for which she received chemoradiotherapy at another hospital. Distant metastases were detected 6 months after the surgery and the patient expired 9 months after surgical resection. We concluded that the presence of sarcomatoid change in IPMN-associated pancreatic adenocarcinoma may indicate poor prognosis. |
| first_indexed | 2024-12-13T20:19:56Z |
| format | Article |
| id | doaj.art-3204a2f2f57441d0863c8e937ab57ca1 |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-12-13T20:19:56Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-3204a2f2f57441d0863c8e937ab57ca12022-12-21T23:32:43ZengElsevierRadiology Case Reports1930-04332021-11-01161134943498An intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component: A case reportChuanhang Zang, BA0Shuai Li, BA1Bo Chi, BA2Shuai Chen, MA3Zhexuan Ye, BA4Department of Cardiothoracic Surgery, The 964th Hospital of the Chinese People's Liberation Army, Changchun, ChinaDepartment of Neurosurgery, The 964th Hospital of the Chinese People's Liberation Army, Changchun, ChinaDepartment of Neurosurgery, The 964th Hospital of the Chinese People's Liberation Army, Changchun, ChinaDepartment of Emergency Surgery, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Ophthalmology, The 964th Hospital of the Chinese People's Liberation Army, Changchun, China; Corresponding author.Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are a risk factor for the development of adenocarcinoma. However, the presence of a component of sarcomatoid carcinoma in the malignant tumor has rarely been described in the literature. A 30-year-old Chinese woman was admitted to our hospital with vague abdominal pain and a poor appetite for 2 months. Computed tomography revealed a huge, unilocular, solid-cystic mass in the pancreatic body, and tail. The patient underwent an en bloc resection of the distal pancreatic tumor with splenectomy and regional lymphadenectomy. Pathologic examination revealed an IPMN associated tubular adenocarcinoma containing a component of sarcomatoid (spindle-shaped cell) carcinoma. Immunohistochemical results revealed that the mononuclear spindle-shaped cells were positive for both pan-cytokeratin and vimentin. There was no evidence of perineural or vascular infiltration, lymph nodal metastasis, or positive surgical margins. The patient developed local recurrence 3 months after surgery for which she received chemoradiotherapy at another hospital. Distant metastases were detected 6 months after the surgery and the patient expired 9 months after surgical resection. We concluded that the presence of sarcomatoid change in IPMN-associated pancreatic adenocarcinoma may indicate poor prognosis.http://www.sciencedirect.com/science/article/pii/S1930043321006099Intraductal papillary mucinous neoplasmIPMNs, Sarcomatoid carcinomaSpindle cell carcinomaPancreasPrognosis |
| spellingShingle | Chuanhang Zang, BA Shuai Li, BA Bo Chi, BA Shuai Chen, MA Zhexuan Ye, BA An intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component: A case report Radiology Case Reports Intraductal papillary mucinous neoplasm IPMNs, Sarcomatoid carcinoma Spindle cell carcinoma Pancreas Prognosis |
| title | An intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component: A case report |
| title_full | An intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component: A case report |
| title_fullStr | An intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component: A case report |
| title_full_unstemmed | An intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component: A case report |
| title_short | An intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component: A case report |
| title_sort | intraductal papillary mucinous neoplasm associated tubular adenocarcinoma with sarcomatoid component a case report |
| topic | Intraductal papillary mucinous neoplasm IPMNs, Sarcomatoid carcinoma Spindle cell carcinoma Pancreas Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1930043321006099 |
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