The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD?
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung pathology characterized by persistent airflow limitation and is the third leading cause of death globally. COPD pathophysiology includes both environmental and host risk factors and the presence of comorbidities contributes to its...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2023-12-01
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| Series: | Exploration of Medicine |
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| Online Access: | https://www.explorationpub.com/Journals/em/Article/1001199 |
| _version_ | 1827393563611103232 |
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| author | Silvia Siragusa Giulia Natali Antonella Maria Nogara Marcello Trevisani Costanza Anna Maria Lagrasta Silvia Pontis |
| author_facet | Silvia Siragusa Giulia Natali Antonella Maria Nogara Marcello Trevisani Costanza Anna Maria Lagrasta Silvia Pontis |
| author_sort | Silvia Siragusa |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is an inflammatory lung pathology characterized by persistent airflow limitation and is the third leading cause of death globally. COPD pathophysiology includes both environmental and host risk factors and the presence of comorbidities contributes to its harmful outcome. Cardiovascular disease (CVD) is closely related to COPD and their coexistence is associated with worse outcomes than either condition alone. COPD impairs the cardiovascular system favoring mostly endothelial dysfunction that is a significant COPD prognostic factor at different stages of the disease. The mechanisms promoting endothelial dysfunction in the systemic and/or pulmonary circulation of COPD patients are different and include systemic inflammation, alteration of adhesion and pro-inflammatory molecules, oxidative stress, cellular senescence, and apoptosis. Nevertheless, the role of endothelium in the onset and progression of COPD and CVD is not yet fully understood. Hence, the purpose of this narrative review is to analyze the literature and provide evidence supporting the importance of endothelial dysfunction in COPD. |
| first_indexed | 2024-03-08T17:50:52Z |
| format | Article |
| id | doaj.art-320611d6905446ec9353c8798e3feb0c |
| institution | Directory Open Access Journal |
| issn | 2692-3106 |
| language | English |
| last_indexed | 2024-03-08T17:50:52Z |
| publishDate | 2023-12-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj.art-320611d6905446ec9353c8798e3feb0c2024-01-02T07:46:00ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062023-12-01461116113410.37349/emed.2023.00199The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD?Silvia Siragusa0https://orcid.org/0000-0002-5751-0277Giulia Natali1https://orcid.org/0000-0003-1655-609XAntonella Maria Nogara2https://orcid.org/0000-0003-2719-7272Marcello Trevisani3https://orcid.org/0009-0005-4384-6545Costanza Anna Maria Lagrasta4https://orcid.org/0000-0003-0552-9205Silvia Pontis5https://orcid.org/0000-0002-9873-4998Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCorporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 43122 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCorporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 43122 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyCorporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 43122 Parma, ItalyChronic obstructive pulmonary disease (COPD) is an inflammatory lung pathology characterized by persistent airflow limitation and is the third leading cause of death globally. COPD pathophysiology includes both environmental and host risk factors and the presence of comorbidities contributes to its harmful outcome. Cardiovascular disease (CVD) is closely related to COPD and their coexistence is associated with worse outcomes than either condition alone. COPD impairs the cardiovascular system favoring mostly endothelial dysfunction that is a significant COPD prognostic factor at different stages of the disease. The mechanisms promoting endothelial dysfunction in the systemic and/or pulmonary circulation of COPD patients are different and include systemic inflammation, alteration of adhesion and pro-inflammatory molecules, oxidative stress, cellular senescence, and apoptosis. Nevertheless, the role of endothelium in the onset and progression of COPD and CVD is not yet fully understood. Hence, the purpose of this narrative review is to analyze the literature and provide evidence supporting the importance of endothelial dysfunction in COPD.https://www.explorationpub.com/Journals/em/Article/1001199endotheliumchronic obstructive pulmonary diseasepulmonaryvascularcardiovascular disease |
| spellingShingle | Silvia Siragusa Giulia Natali Antonella Maria Nogara Marcello Trevisani Costanza Anna Maria Lagrasta Silvia Pontis The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD? Exploration of Medicine endothelium chronic obstructive pulmonary disease pulmonary vascular cardiovascular disease |
| title | The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD? |
| title_full | The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD? |
| title_fullStr | The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD? |
| title_full_unstemmed | The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD? |
| title_short | The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD? |
| title_sort | role of pulmonary vascular endothelium in chronic obstructive pulmonary disease copd does endothelium play a role in the onset and progression of copd |
| topic | endothelium chronic obstructive pulmonary disease pulmonary vascular cardiovascular disease |
| url | https://www.explorationpub.com/Journals/em/Article/1001199 |
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