A systematic literature review of the clinical signs and symptoms of veno‐occlusive disease/sinusoidal obstruction syndrome after haematopoietic cell transplantation in adults and children
Abstract Veno‐occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a rare, serious complication following haematopoietic cell transplantation (HCT). This systematic literature review evaluated differences in clinical manifestations of VOD/SOS post‐HCT in adults and children. Medline and Em...
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.612 |
| _version_ | 1827318922640097280 |
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| author | James Angus Shannon Connolly William Letton Chris Martin Alison Martin |
| author_facet | James Angus Shannon Connolly William Letton Chris Martin Alison Martin |
| author_sort | James Angus |
| collection | DOAJ |
| description | Abstract Veno‐occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a rare, serious complication following haematopoietic cell transplantation (HCT). This systematic literature review evaluated differences in clinical manifestations of VOD/SOS post‐HCT in adults and children. Medline and Embase were searched up to 4 March 2021 for reports of VOD/SOS post‐HCT; VOD/SOS diagnostic guidelines were included. Publications were evaluated based on inclusion of five cardinal clinical features of VOD/SOS (ascites, hepatomegaly, hyperbilirubinaemia, right upper quadrant [RUQ] pain and weight gain ≥5%). Overall, 204 publications were included. At diagnosis, hyperbilirubinaemia was more common in adults (93%) versus children (82%), weight gain ≥5% and hepatomegaly were more common in children (86%, 89%) versus adults (73%, 76%) and ascites and RUQ pain were similar between age groups. While 40% of cases had all five cardinal features, age was not a substantial determinant of the likelihood of missing any single specific feature. The proportion of cases, where hyperbilirubinaemia was the first recorded feature, was higher in children versus adults; weight gain and RUQ pain appeared first in a greater proportion of adults versus children. VOD/SOS diagnosis can be challenging; features may not present in a distinct sequence. This necessitates continuous vigilance by those involved in patient monitoring post‐HCT. |
| first_indexed | 2024-03-12T14:06:28Z |
| format | Article |
| id | doaj.art-32063c5fec2f4a81b253c6a626d4ac53 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-04-25T00:11:02Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
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| series | eJHaem |
| spelling | doaj.art-32063c5fec2f4a81b253c6a626d4ac532024-03-13T13:30:47ZengWileyeJHaem2688-61462023-02-014119920610.1002/jha2.612A systematic literature review of the clinical signs and symptoms of veno‐occlusive disease/sinusoidal obstruction syndrome after haematopoietic cell transplantation in adults and childrenJames Angus0Shannon Connolly1William Letton2Chris Martin3Alison Martin4Jazz Pharmaceuticals Oxford UKCrystallise Ltd. Essex UKCrystallise Ltd. Essex UKCrystallise Ltd. Essex UKCrystallise Ltd. Essex UKAbstract Veno‐occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a rare, serious complication following haematopoietic cell transplantation (HCT). This systematic literature review evaluated differences in clinical manifestations of VOD/SOS post‐HCT in adults and children. Medline and Embase were searched up to 4 March 2021 for reports of VOD/SOS post‐HCT; VOD/SOS diagnostic guidelines were included. Publications were evaluated based on inclusion of five cardinal clinical features of VOD/SOS (ascites, hepatomegaly, hyperbilirubinaemia, right upper quadrant [RUQ] pain and weight gain ≥5%). Overall, 204 publications were included. At diagnosis, hyperbilirubinaemia was more common in adults (93%) versus children (82%), weight gain ≥5% and hepatomegaly were more common in children (86%, 89%) versus adults (73%, 76%) and ascites and RUQ pain were similar between age groups. While 40% of cases had all five cardinal features, age was not a substantial determinant of the likelihood of missing any single specific feature. The proportion of cases, where hyperbilirubinaemia was the first recorded feature, was higher in children versus adults; weight gain and RUQ pain appeared first in a greater proportion of adults versus children. VOD/SOS diagnosis can be challenging; features may not present in a distinct sequence. This necessitates continuous vigilance by those involved in patient monitoring post‐HCT.https://doi.org/10.1002/jha2.612adultchildrendiagnosissinusoidal obstruction syndromeveno‐occlusive disease |
| spellingShingle | James Angus Shannon Connolly William Letton Chris Martin Alison Martin A systematic literature review of the clinical signs and symptoms of veno‐occlusive disease/sinusoidal obstruction syndrome after haematopoietic cell transplantation in adults and children eJHaem adult children diagnosis sinusoidal obstruction syndrome veno‐occlusive disease |
| title | A systematic literature review of the clinical signs and symptoms of veno‐occlusive disease/sinusoidal obstruction syndrome after haematopoietic cell transplantation in adults and children |
| title_full | A systematic literature review of the clinical signs and symptoms of veno‐occlusive disease/sinusoidal obstruction syndrome after haematopoietic cell transplantation in adults and children |
| title_fullStr | A systematic literature review of the clinical signs and symptoms of veno‐occlusive disease/sinusoidal obstruction syndrome after haematopoietic cell transplantation in adults and children |
| title_full_unstemmed | A systematic literature review of the clinical signs and symptoms of veno‐occlusive disease/sinusoidal obstruction syndrome after haematopoietic cell transplantation in adults and children |
| title_short | A systematic literature review of the clinical signs and symptoms of veno‐occlusive disease/sinusoidal obstruction syndrome after haematopoietic cell transplantation in adults and children |
| title_sort | systematic literature review of the clinical signs and symptoms of veno occlusive disease sinusoidal obstruction syndrome after haematopoietic cell transplantation in adults and children |
| topic | adult children diagnosis sinusoidal obstruction syndrome veno‐occlusive disease |
| url | https://doi.org/10.1002/jha2.612 |
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