ORGINAL PAPER<br>Modulation of the tissue defense system by squalene in cyclophosphamide induced toxicity in rats

ORGINAL PAPER<br>Modulation of the tissue defense system by squalene in cyclophosphamide induced toxicity in rats

Introduction: Antineoplastic drug, Cyclophosphamide (CP), is a widely used drug that causes toxicity through its metabolites, phosphoramide mustard and acrolein. Squalene (SQ), an intermediate in the cholesterol metabolism has antioxidant and membrane stabilizing property. In the present study, the...

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Bibliographic Details
Main Authors: Subramanian Senthilkumar, Kesavarao Kumar Ebenezar, Venkatachalem Sathish, Surinderkumar Yogeeta, Thiruvengadam Devaki
Format: Article
Language:English
Published: Termedia Publishing House 2006-06-01
Series:Archives of Medical Science
Subjects:
enzymic antioxidants
TBARS
reactive oxygen species
free radicals
liver
kidney
Online Access:http://www.termedia.pl/magazine.php?magazine_id=19&article_id=6200&magazine_subpage=FULL_TEXT

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