A Multistep Approach to Deal With Advanced Heart Failure: A Case Report on the Positive Effect of Cardiac Contractility Modulation Therapy on Pulmonary Pressure Measured by CardioMEMS
During the last years, the management of heart failure (HF) made substantial progress, focusing on device-based therapies to meet the demands of this complex syndrome. In this case report, we present a multistep approach to deal with HF. Specifically, we report the first patient subjected to the imp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.874433/full |
| _version_ | 1819025437899096064 |
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| author | Valeria Visco Cristina Esposito Michele Manzo Antonio Fiorentino Gennaro Galasso Carmine Vecchione Carmine Vecchione Michele Ciccarelli |
| author_facet | Valeria Visco Cristina Esposito Michele Manzo Antonio Fiorentino Gennaro Galasso Carmine Vecchione Carmine Vecchione Michele Ciccarelli |
| author_sort | Valeria Visco |
| collection | DOAJ |
| description | During the last years, the management of heart failure (HF) made substantial progress, focusing on device-based therapies to meet the demands of this complex syndrome. In this case report, we present a multistep approach to deal with HF. Specifically, we report the first patient subjected to the implantation of both Optimizer Smart® (Impulse Dynamics Inc., Marlton, NJ, USA) and CardioMEMS devices. A 72-year-old male patient with HF and reduced ejection fraction (HFrEF) was admitted to our cardiology department in January 2021, following a progressive shortening of the time between hospitalizations for levosimendan infusions. Specifically, the patient was monitored daily by CardioMEMS, and a strategy of levosimendan infusions guided by the device had been adopted. He was also a carrier of MitraClips and cardiac resynchronization therapy defibrillator (CRT-D) and had optimized HF medical therapy. In January 2021, the patient implanted Optimizer Smart® device for cardiac contractility modulation (CCM) therapy because of poor response to therapy and elevated pulmonary artery pressure (PAP). CCM significantly reduced PAP values following discharge (systolic PAP 33.67 ± 2.92 vs. 40.6 ± 3.37 mmHg, diastolic PAP 14.5 ± 2.01 vs. 22.5 ± 2.53 mmHg, mean PAP 22.87 ± 2.20 vs. 30.9 ± 2.99 mmHg, HR 60.93 ± 1.53 vs. 80.83 ± 3.66 bpm; p < 0.0001), with persisting effect at 9 months. The usefulness of CCM is objectively demonstrated for the first time by continuous invasive monitoring of PAP by CardioMEMS, which can suggest the correct timing for CCM implantation. |
| first_indexed | 2024-12-21T05:10:40Z |
| format | Article |
| id | doaj.art-3206d553c24e43fea79eb68f200095bf |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-21T05:10:40Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-3206d553c24e43fea79eb68f200095bf2022-12-21T19:15:04ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-04-01910.3389/fcvm.2022.874433874433A Multistep Approach to Deal With Advanced Heart Failure: A Case Report on the Positive Effect of Cardiac Contractility Modulation Therapy on Pulmonary Pressure Measured by CardioMEMSValeria Visco0Cristina Esposito1Michele Manzo2Antonio Fiorentino3Gennaro Galasso4Carmine Vecchione5Carmine Vecchione6Michele Ciccarelli7Department of Medicine, Surgery and Dentistry, University of Salerno, Fisciano, ItalyCardiology Unit, University Hospital “San Giovanni di Dio e Ruggi D'Aragona”, Salerno, ItalyCardiology Unit, University Hospital “San Giovanni di Dio e Ruggi D'Aragona”, Salerno, ItalyImpulse Dynamics Germany GmbH, Frankfurt Am Main, GermanyDepartment of Medicine, Surgery and Dentistry, University of Salerno, Fisciano, ItalyDepartment of Medicine, Surgery and Dentistry, University of Salerno, Fisciano, ItalyVascular Physiopathology Unit, IRCCS Neuromed, Pozzilli, ItalyDepartment of Medicine, Surgery and Dentistry, University of Salerno, Fisciano, ItalyDuring the last years, the management of heart failure (HF) made substantial progress, focusing on device-based therapies to meet the demands of this complex syndrome. In this case report, we present a multistep approach to deal with HF. Specifically, we report the first patient subjected to the implantation of both Optimizer Smart® (Impulse Dynamics Inc., Marlton, NJ, USA) and CardioMEMS devices. A 72-year-old male patient with HF and reduced ejection fraction (HFrEF) was admitted to our cardiology department in January 2021, following a progressive shortening of the time between hospitalizations for levosimendan infusions. Specifically, the patient was monitored daily by CardioMEMS, and a strategy of levosimendan infusions guided by the device had been adopted. He was also a carrier of MitraClips and cardiac resynchronization therapy defibrillator (CRT-D) and had optimized HF medical therapy. In January 2021, the patient implanted Optimizer Smart® device for cardiac contractility modulation (CCM) therapy because of poor response to therapy and elevated pulmonary artery pressure (PAP). CCM significantly reduced PAP values following discharge (systolic PAP 33.67 ± 2.92 vs. 40.6 ± 3.37 mmHg, diastolic PAP 14.5 ± 2.01 vs. 22.5 ± 2.53 mmHg, mean PAP 22.87 ± 2.20 vs. 30.9 ± 2.99 mmHg, HR 60.93 ± 1.53 vs. 80.83 ± 3.66 bpm; p < 0.0001), with persisting effect at 9 months. The usefulness of CCM is objectively demonstrated for the first time by continuous invasive monitoring of PAP by CardioMEMS, which can suggest the correct timing for CCM implantation.https://www.frontiersin.org/articles/10.3389/fcvm.2022.874433/fullheart failurecase reportOptimizer Smart®cardiac contractility modulationCardioMEMStelemonitoring |
| spellingShingle | Valeria Visco Cristina Esposito Michele Manzo Antonio Fiorentino Gennaro Galasso Carmine Vecchione Carmine Vecchione Michele Ciccarelli A Multistep Approach to Deal With Advanced Heart Failure: A Case Report on the Positive Effect of Cardiac Contractility Modulation Therapy on Pulmonary Pressure Measured by CardioMEMS Frontiers in Cardiovascular Medicine heart failure case report Optimizer Smart® cardiac contractility modulation CardioMEMS telemonitoring |
| title | A Multistep Approach to Deal With Advanced Heart Failure: A Case Report on the Positive Effect of Cardiac Contractility Modulation Therapy on Pulmonary Pressure Measured by CardioMEMS |
| title_full | A Multistep Approach to Deal With Advanced Heart Failure: A Case Report on the Positive Effect of Cardiac Contractility Modulation Therapy on Pulmonary Pressure Measured by CardioMEMS |
| title_fullStr | A Multistep Approach to Deal With Advanced Heart Failure: A Case Report on the Positive Effect of Cardiac Contractility Modulation Therapy on Pulmonary Pressure Measured by CardioMEMS |
| title_full_unstemmed | A Multistep Approach to Deal With Advanced Heart Failure: A Case Report on the Positive Effect of Cardiac Contractility Modulation Therapy on Pulmonary Pressure Measured by CardioMEMS |
| title_short | A Multistep Approach to Deal With Advanced Heart Failure: A Case Report on the Positive Effect of Cardiac Contractility Modulation Therapy on Pulmonary Pressure Measured by CardioMEMS |
| title_sort | multistep approach to deal with advanced heart failure a case report on the positive effect of cardiac contractility modulation therapy on pulmonary pressure measured by cardiomems |
| topic | heart failure case report Optimizer Smart® cardiac contractility modulation CardioMEMS telemonitoring |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.874433/full |
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