Therapy and Outcome of Prolonged Veno-Venous ECMO Therapy of Critically Ill ARDS Patients
Veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) therapy has become increasingly used and established in many hospitals as a routine treatment. With ECMO-therapy being a resource-demanding procedure, it is of interest whether a more prolonged VV-ECMO treatment would hold sufficient therapeu...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/7/2499 |
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| author | Armin N. Flinspach Florian J. Raimann Frederike Bauer Kai Zacharowski Angelo Ippolito Hendrik Booke |
| author_facet | Armin N. Flinspach Florian J. Raimann Frederike Bauer Kai Zacharowski Angelo Ippolito Hendrik Booke |
| author_sort | Armin N. Flinspach |
| collection | DOAJ |
| description | Veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) therapy has become increasingly used and established in many hospitals as a routine treatment. With ECMO-therapy being a resource-demanding procedure, it is of interest whether a more prolonged VV-ECMO treatment would hold sufficient therapeutic success. Our retrospective study included all VV-ECMO runs from 1 January 2020 to 31 June 2022. We divided all runs into four groups (<14 days, 14–27, 28–49, 50+) of different durations and looked for differences overall in hospital survival. Additionally, corresponding treatments and therapeutic modalities, as well as laboratory results, were analyzed. We included 117 patients. Of those, 97 (82.9%) received a VV-ECMO treatment longer than two weeks. We did not find a significant association between ECMO duration (<i>p</i> = 0.15) and increased mortality though a significant correlation between the patients’ age and their probability of survival (<i>p</i> = 0.02). Notably, we found significantly lower interleukin-6 levels with an increase in therapy duration (<i>p</i> < 0.01). Our findings show no association between the duration of ECMO therapy and mortality. Thus, the treatment duration alone may not be used for making assumptions about the prospect of survival. However, attention is also increasingly focused on long-term outcomes, such as post-intensive care syndrome with severe impairments. |
| first_indexed | 2024-03-11T05:33:33Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T05:33:33Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3207b6e52c4849118839ff51d9ef71cf2023-11-17T16:57:59ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01127249910.3390/jcm12072499Therapy and Outcome of Prolonged Veno-Venous ECMO Therapy of Critically Ill ARDS PatientsArmin N. Flinspach0Florian J. Raimann1Frederike Bauer2Kai Zacharowski3Angelo Ippolito4Hendrik Booke5Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, Theodor-Stern Kai 7, 60590 Frankfurt am Main, GermanyDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, Theodor-Stern Kai 7, 60590 Frankfurt am Main, GermanyDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, Theodor-Stern Kai 7, 60590 Frankfurt am Main, GermanyDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, Theodor-Stern Kai 7, 60590 Frankfurt am Main, GermanyDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, Theodor-Stern Kai 7, 60590 Frankfurt am Main, GermanyDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, Theodor-Stern Kai 7, 60590 Frankfurt am Main, GermanyVeno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) therapy has become increasingly used and established in many hospitals as a routine treatment. With ECMO-therapy being a resource-demanding procedure, it is of interest whether a more prolonged VV-ECMO treatment would hold sufficient therapeutic success. Our retrospective study included all VV-ECMO runs from 1 January 2020 to 31 June 2022. We divided all runs into four groups (<14 days, 14–27, 28–49, 50+) of different durations and looked for differences overall in hospital survival. Additionally, corresponding treatments and therapeutic modalities, as well as laboratory results, were analyzed. We included 117 patients. Of those, 97 (82.9%) received a VV-ECMO treatment longer than two weeks. We did not find a significant association between ECMO duration (<i>p</i> = 0.15) and increased mortality though a significant correlation between the patients’ age and their probability of survival (<i>p</i> = 0.02). Notably, we found significantly lower interleukin-6 levels with an increase in therapy duration (<i>p</i> < 0.01). Our findings show no association between the duration of ECMO therapy and mortality. Thus, the treatment duration alone may not be used for making assumptions about the prospect of survival. However, attention is also increasingly focused on long-term outcomes, such as post-intensive care syndrome with severe impairments.https://www.mdpi.com/2077-0383/12/7/2499critical careacute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2extracorporeal membrane oxygenation |
| spellingShingle | Armin N. Flinspach Florian J. Raimann Frederike Bauer Kai Zacharowski Angelo Ippolito Hendrik Booke Therapy and Outcome of Prolonged Veno-Venous ECMO Therapy of Critically Ill ARDS Patients Journal of Clinical Medicine critical care acute respiratory distress syndrome severe acute respiratory syndrome coronavirus 2 extracorporeal membrane oxygenation |
| title | Therapy and Outcome of Prolonged Veno-Venous ECMO Therapy of Critically Ill ARDS Patients |
| title_full | Therapy and Outcome of Prolonged Veno-Venous ECMO Therapy of Critically Ill ARDS Patients |
| title_fullStr | Therapy and Outcome of Prolonged Veno-Venous ECMO Therapy of Critically Ill ARDS Patients |
| title_full_unstemmed | Therapy and Outcome of Prolonged Veno-Venous ECMO Therapy of Critically Ill ARDS Patients |
| title_short | Therapy and Outcome of Prolonged Veno-Venous ECMO Therapy of Critically Ill ARDS Patients |
| title_sort | therapy and outcome of prolonged veno venous ecmo therapy of critically ill ards patients |
| topic | critical care acute respiratory distress syndrome severe acute respiratory syndrome coronavirus 2 extracorporeal membrane oxygenation |
| url | https://www.mdpi.com/2077-0383/12/7/2499 |
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