Compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in mice
Dark tea is a fermented tea that plays a role in regulating the homeostasis of intestinal microorganisms. Previous studies have found that dark tea can improve obesity and has a lipid-lowering effect. In this study, green tea, Ilex latifolia Thunb (kuding tea) and Momordica grosvenori (Luo Han Guo)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1082250/full |
| _version_ | 1797946969583255552 |
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| author | Jianyu Qu Mengke Ye Chi Wen Xianyu Cheng Lirui Zou Mengyao Li Xiangyan Liu Zhonghua Liu Lixin Wen Ji Wang Ji Wang Ji Wang |
| author_facet | Jianyu Qu Mengke Ye Chi Wen Xianyu Cheng Lirui Zou Mengyao Li Xiangyan Liu Zhonghua Liu Lixin Wen Ji Wang Ji Wang Ji Wang |
| author_sort | Jianyu Qu |
| collection | DOAJ |
| description | Dark tea is a fermented tea that plays a role in regulating the homeostasis of intestinal microorganisms. Previous studies have found that dark tea can improve obesity and has a lipid-lowering effect. In this study, green tea, Ilex latifolia Thunb (kuding tea) and Momordica grosvenori (Luo Han Guo) were added to a new compound dark tea (CDT), to improve the taste and health of this beverage. High-fat diet-fed C57BL/6J mice were treated with low- (6 mg/mL) or high- (12 mg/mL) concentrations of CDT for 18 weeks to assess their effect on lipid metabolism. Our results suggest that low- and high-concentrations of CDT could reduce body weight by 15 and 16% and by 44 and 38% of body fat, respectively, by attenuating body weight gain and fat accumulation, improving glucose tolerance, alleviating metabolic endotoxemia, and regulating the mRNA expression levels of lipid metabolism-related genes. In addition, low concentrations of CDT were able to reduce the abundance of Desulfovibrio, which is positively associated with obesity, and increase the abundance of Ruminococcus, which are negatively associated with obesity. This study demonstrates the effect of CDT on ameliorating lipid metabolism and provides new insights into the research and development of functional tea beverages. |
| first_indexed | 2024-04-10T21:20:26Z |
| format | Article |
| id | doaj.art-3208b8d34f874839898c840480b7da80 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T21:20:26Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-3208b8d34f874839898c840480b7da802023-01-20T06:09:22ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-011010.3389/fnut.2023.10822501082250Compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in miceJianyu Qu0Mengke Ye1Chi Wen2Xianyu Cheng3Lirui Zou4Mengyao Li5Xiangyan Liu6Zhonghua Liu7Lixin Wen8Ji Wang9Ji Wang10Ji Wang11Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, ChinaHunan Chu Ming Tea Industry Co., Ltd., Changsha, ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, ChinaKey Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha, ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, ChinaAnimal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaChangsha Lvye Biotechnology Co., Ltd., Changsha, ChinaDark tea is a fermented tea that plays a role in regulating the homeostasis of intestinal microorganisms. Previous studies have found that dark tea can improve obesity and has a lipid-lowering effect. In this study, green tea, Ilex latifolia Thunb (kuding tea) and Momordica grosvenori (Luo Han Guo) were added to a new compound dark tea (CDT), to improve the taste and health of this beverage. High-fat diet-fed C57BL/6J mice were treated with low- (6 mg/mL) or high- (12 mg/mL) concentrations of CDT for 18 weeks to assess their effect on lipid metabolism. Our results suggest that low- and high-concentrations of CDT could reduce body weight by 15 and 16% and by 44 and 38% of body fat, respectively, by attenuating body weight gain and fat accumulation, improving glucose tolerance, alleviating metabolic endotoxemia, and regulating the mRNA expression levels of lipid metabolism-related genes. In addition, low concentrations of CDT were able to reduce the abundance of Desulfovibrio, which is positively associated with obesity, and increase the abundance of Ruminococcus, which are negatively associated with obesity. This study demonstrates the effect of CDT on ameliorating lipid metabolism and provides new insights into the research and development of functional tea beverages.https://www.frontiersin.org/articles/10.3389/fnut.2023.1082250/fullcompound dark teagut microbiotaobesitylipid metabolismhepatic steatosis |
| spellingShingle | Jianyu Qu Mengke Ye Chi Wen Xianyu Cheng Lirui Zou Mengyao Li Xiangyan Liu Zhonghua Liu Lixin Wen Ji Wang Ji Wang Ji Wang Compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in mice Frontiers in Nutrition compound dark tea gut microbiota obesity lipid metabolism hepatic steatosis |
| title | Compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in mice |
| title_full | Compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in mice |
| title_fullStr | Compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in mice |
| title_full_unstemmed | Compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in mice |
| title_short | Compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in mice |
| title_sort | compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in mice |
| topic | compound dark tea gut microbiota obesity lipid metabolism hepatic steatosis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1082250/full |
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