Leveraging CD16 fusion receptors to remodel the immune response for enhancing anti-tumor immunotherapy in iPSC-derived NK cells

Leveraging CD16 fusion receptors to remodel the immune response for enhancing anti-tumor immunotherapy in iPSC-derived NK cells

Abstract Background The cytotoxicity of NK cells is largely dependent on IgG Fc receptor CD16a, which mediates antibody-dependent cell-mediated cytotoxicity (ADCC). The high-affinity and non-cleavable CD16 (hnCD16) is developed and demonstrated a multi-tumor killing potential. However, the hnCD16 re...

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Bibliographic Details
Main Authors: Fanyi Meng, Siqi Zhang, Juan Xie, Yuan Zhou, Qingling Wu, Binyan Lu, Shixin Zhou, Xiangyu Zhao, Yang Li
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Hematology & Oncology
Subjects:
Induced pluripotent stem cells
NK-cell differentiation
CD16 fusion receptor
Immunotherapy
Online Access:https://doi.org/10.1186/s13045-023-01455-z

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