Design and evaluation of sodium alginate/polyvinyl alcohol blend hydrogel for 3D bioprinting cartilage scaffold: molecular dynamics simulation and experimental method
To determine the optimum composition of AS/PVA for bioprinting cartilage scaffold, a molecular simulation combining experimental method was employed to investigate the microstructure, physicochemical properties and printability of AS/PVA blending hydrogels at different compositions. The compatibilit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785421015738 |
| _version_ | 1818312561997643776 |
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| author | Qinghua Wei Rongbin Yang Daocen Sun Jiayi Zhou Mingyang Li Yingfeng Zhang Yanen Wang |
| author_facet | Qinghua Wei Rongbin Yang Daocen Sun Jiayi Zhou Mingyang Li Yingfeng Zhang Yanen Wang |
| author_sort | Qinghua Wei |
| collection | DOAJ |
| description | To determine the optimum composition of AS/PVA for bioprinting cartilage scaffold, a molecular simulation combining experimental method was employed to investigate the microstructure, physicochemical properties and printability of AS/PVA blending hydrogels at different compositions. The compatibility analysis results show that SA and PVA have a good compatibility, they are miscible at any compositions. Mechanical properties analysis indicates that the tensile strength of 8SA/2PVA is the best, and compared with 8SA/2PVA, 7SA/3PVA possesses a better toughness and similar tensile strength. Moreover, FFV value and pore size decrease with the increase of PVA content, indicating the incorporation of PVA makes the system denser and pore size smaller, and the hydrogel of 8SA/2PVA possesses the optimal pore structure for the proliferation of chondrocytes. The main reason behind the conclusions obtained above is attributed to the strong hydrogen bond and intermolecular interaction between SA and PVA molecular chains. Finally, the results of printability indicates that, due to the fluidity of PVA, the forming quality becomes worse with the increase of PVA content, and when the PVA content in hydrogel precursors is within 30 wt.%, the forming quality is relatively good. Comprehensive considering the results above, the blend hydrogel of 8SA/2PVA was selected out and considered to be the most suitable for 3D printing cartilage scaffolds. |
| first_indexed | 2024-12-13T08:19:49Z |
| format | Article |
| id | doaj.art-320aa8b2205e40978015d4f85fa6d554 |
| institution | Directory Open Access Journal |
| issn | 2238-7854 |
| language | English |
| last_indexed | 2024-12-13T08:19:49Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj.art-320aa8b2205e40978015d4f85fa6d5542022-12-21T23:54:01ZengElsevierJournal of Materials Research and Technology2238-78542022-03-01176678Design and evaluation of sodium alginate/polyvinyl alcohol blend hydrogel for 3D bioprinting cartilage scaffold: molecular dynamics simulation and experimental methodQinghua Wei0Rongbin Yang1Daocen Sun2Jiayi Zhou3Mingyang Li4Yingfeng Zhang5Yanen Wang6Industry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an, 710072, PR China; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, China; Corresponding author.Industry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an, 710072, PR China; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an, 710072, PR China; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an, 710072, PR China; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an, 710072, PR China; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an, 710072, PR China; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an, 710072, PR China; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, ChinaTo determine the optimum composition of AS/PVA for bioprinting cartilage scaffold, a molecular simulation combining experimental method was employed to investigate the microstructure, physicochemical properties and printability of AS/PVA blending hydrogels at different compositions. The compatibility analysis results show that SA and PVA have a good compatibility, they are miscible at any compositions. Mechanical properties analysis indicates that the tensile strength of 8SA/2PVA is the best, and compared with 8SA/2PVA, 7SA/3PVA possesses a better toughness and similar tensile strength. Moreover, FFV value and pore size decrease with the increase of PVA content, indicating the incorporation of PVA makes the system denser and pore size smaller, and the hydrogel of 8SA/2PVA possesses the optimal pore structure for the proliferation of chondrocytes. The main reason behind the conclusions obtained above is attributed to the strong hydrogen bond and intermolecular interaction between SA and PVA molecular chains. Finally, the results of printability indicates that, due to the fluidity of PVA, the forming quality becomes worse with the increase of PVA content, and when the PVA content in hydrogel precursors is within 30 wt.%, the forming quality is relatively good. Comprehensive considering the results above, the blend hydrogel of 8SA/2PVA was selected out and considered to be the most suitable for 3D printing cartilage scaffolds.http://www.sciencedirect.com/science/article/pii/S2238785421015738Sodium alginatePolyvinyl alcoholCartilage scaffoldBioprintingMolecular dynamics simulation |
| spellingShingle | Qinghua Wei Rongbin Yang Daocen Sun Jiayi Zhou Mingyang Li Yingfeng Zhang Yanen Wang Design and evaluation of sodium alginate/polyvinyl alcohol blend hydrogel for 3D bioprinting cartilage scaffold: molecular dynamics simulation and experimental method Journal of Materials Research and Technology Sodium alginate Polyvinyl alcohol Cartilage scaffold Bioprinting Molecular dynamics simulation |
| title | Design and evaluation of sodium alginate/polyvinyl alcohol blend hydrogel for 3D bioprinting cartilage scaffold: molecular dynamics simulation and experimental method |
| title_full | Design and evaluation of sodium alginate/polyvinyl alcohol blend hydrogel for 3D bioprinting cartilage scaffold: molecular dynamics simulation and experimental method |
| title_fullStr | Design and evaluation of sodium alginate/polyvinyl alcohol blend hydrogel for 3D bioprinting cartilage scaffold: molecular dynamics simulation and experimental method |
| title_full_unstemmed | Design and evaluation of sodium alginate/polyvinyl alcohol blend hydrogel for 3D bioprinting cartilage scaffold: molecular dynamics simulation and experimental method |
| title_short | Design and evaluation of sodium alginate/polyvinyl alcohol blend hydrogel for 3D bioprinting cartilage scaffold: molecular dynamics simulation and experimental method |
| title_sort | design and evaluation of sodium alginate polyvinyl alcohol blend hydrogel for 3d bioprinting cartilage scaffold molecular dynamics simulation and experimental method |
| topic | Sodium alginate Polyvinyl alcohol Cartilage scaffold Bioprinting Molecular dynamics simulation |
| url | http://www.sciencedirect.com/science/article/pii/S2238785421015738 |
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