Testosterone, estradiol and their ratio in male patients with acute coronary syndrome
The role of androgens and estrogens in cardiovascular disease is a subject of ongoing studies. Therefore, we aim to explore the association of testosterone (T), estradiol and their ratio with cardiovascular risk factors and severity of cardiac ischemia in male patients with acute coronary syndrome....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2024-03-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/113755/download/pdf/ |
| _version_ | 1797242735477915648 |
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| author | Savi Shishkov Kiril Hristozov Atanas Angelov Svetoslava Slavcheva Yana Bocheva Mila Boyadzhieva |
| author_facet | Savi Shishkov Kiril Hristozov Atanas Angelov Svetoslava Slavcheva Yana Bocheva Mila Boyadzhieva |
| author_sort | Savi Shishkov |
| collection | DOAJ |
| description | The role of androgens and estrogens in cardiovascular disease is a subject of ongoing studies. Therefore, we aim to explore the association of testosterone (T), estradiol and their ratio with cardiovascular risk factors and severity of cardiac ischemia in male patients with acute coronary syndrome. (ACS) n = 72 and controls (n = 35) Lower values of both total and free T were found in the ACS group compared to controls (8.97 vs. 10.98 nmol/l, p = 0.001 for total T and 0.189 vs. 0.223 nmol/l, p = 0.006 for free T). Patients with myocardial infarction with ST-elevation had significantly lower T fractions compared to ACS without ST-elevation. The T to estradiol ratio was significantly lower in the ACS group compared to controls and is lowest in those with STEMI. Also, all testosterone fractions – free, bioavailable, and free T, are lower in patients with ACS compared to controls. Based on these observations a conclusion can be drawn that amore estrogenic environment is associated with ST-elevation and correlates with the severity of ACS in male patients. |
| first_indexed | 2024-04-24T18:43:57Z |
| format | Article |
| id | doaj.art-320cd49a6335425480e90ac5ef9a58da |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-04-24T18:43:57Z |
| publishDate | 2024-03-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-320cd49a6335425480e90ac5ef9a58da2024-03-27T07:31:14ZengPensoft PublishersPharmacia2603-557X2024-03-01711510.3897/pharmacia.71.e113755113755Testosterone, estradiol and their ratio in male patients with acute coronary syndromeSavi Shishkov0Kiril Hristozov1Atanas Angelov2Svetoslava Slavcheva3Yana Bocheva4Mila Boyadzhieva5Medical University of VarnaMedical University of VarnaMedical University of VarnaMedical University of VarnaMedical University of VarnaMedical University of VarnaThe role of androgens and estrogens in cardiovascular disease is a subject of ongoing studies. Therefore, we aim to explore the association of testosterone (T), estradiol and their ratio with cardiovascular risk factors and severity of cardiac ischemia in male patients with acute coronary syndrome. (ACS) n = 72 and controls (n = 35) Lower values of both total and free T were found in the ACS group compared to controls (8.97 vs. 10.98 nmol/l, p = 0.001 for total T and 0.189 vs. 0.223 nmol/l, p = 0.006 for free T). Patients with myocardial infarction with ST-elevation had significantly lower T fractions compared to ACS without ST-elevation. The T to estradiol ratio was significantly lower in the ACS group compared to controls and is lowest in those with STEMI. Also, all testosterone fractions – free, bioavailable, and free T, are lower in patients with ACS compared to controls. Based on these observations a conclusion can be drawn that amore estrogenic environment is associated with ST-elevation and correlates with the severity of ACS in male patients.https://pharmacia.pensoft.net/article/113755/download/pdf/ |
| spellingShingle | Savi Shishkov Kiril Hristozov Atanas Angelov Svetoslava Slavcheva Yana Bocheva Mila Boyadzhieva Testosterone, estradiol and their ratio in male patients with acute coronary syndrome Pharmacia |
| title | Testosterone, estradiol and their ratio in male patients with acute coronary syndrome |
| title_full | Testosterone, estradiol and their ratio in male patients with acute coronary syndrome |
| title_fullStr | Testosterone, estradiol and their ratio in male patients with acute coronary syndrome |
| title_full_unstemmed | Testosterone, estradiol and their ratio in male patients with acute coronary syndrome |
| title_short | Testosterone, estradiol and their ratio in male patients with acute coronary syndrome |
| title_sort | testosterone estradiol and their ratio in male patients with acute coronary syndrome |
| url | https://pharmacia.pensoft.net/article/113755/download/pdf/ |
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