Novel 1-(1-Arylimiazolin-2-Yl)-3-Arylalkilurea Derivatives with Modulatory Activity on Opioid MOP Receptors

Novel 1-(1-Arylimiazolin-2-Yl)-3-Arylalkilurea Derivatives with Modulatory Activity on Opioid MOP Receptors

μ-opioid receptor ligands such as morphine and fentanyl are the most known and potent painkillers. However, the severe side effects seen with their use significantly limit their widespread use. The continuous broadening of knowledge about the properties of the interactions of the MOP receptor (human...

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Bibliographic Details
Main Authors: Dominik Straszak, Sylwia Woźniak, Agata Siwek, Monika Głuch-Lutwin, Marcin Kołaczkowski, Aldona Pietrzak, Bartłomiej Drop, Dariusz Matosiuk
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Molecules
Subjects:
MOP receptor
OP3 receptor
allosterism
β-arrestin
1-aryl-2-aminoimidazoline-2
Online Access:https://www.mdpi.com/1420-3049/29/3/571

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