New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis
Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancrea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1345350 |
| _version_ | 1827809394403835904 |
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| author | Jieli Shen Daisy F. Rangel Dat Ha Amy S. Lee |
| author_facet | Jieli Shen Daisy F. Rangel Dat Ha Amy S. Lee |
| author_sort | Jieli Shen |
| collection | DOAJ |
| description | Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancreas impairs acinar-to-ductal metaplasia, whereas in the uterus, Grp94 loss induces squamous cell metaplasia; both resulting in tumor suppression. |
| first_indexed | 2024-03-11T22:41:35Z |
| format | Article |
| id | doaj.art-320f76021daa4e5fa370b30ecc786b6b |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:35Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-320f76021daa4e5fa370b30ecc786b6b2023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-11-014610.1080/23723556.2017.13453501345350New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesisJieli Shen0Daisy F. Rangel1Dat Ha2Amy S. Lee3University of Southern CaliforniaUniversity of Southern CaliforniaUniversity of Southern CaliforniaUniversity of Southern CaliforniaMetaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancreas impairs acinar-to-ductal metaplasia, whereas in the uterus, Grp94 loss induces squamous cell metaplasia; both resulting in tumor suppression.http://dx.doi.org/10.1080/23723556.2017.1345350er chaperonegrp78grp94metaplasiamouse modelspancreatic cancer |
| spellingShingle | Jieli Shen Daisy F. Rangel Dat Ha Amy S. Lee New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis Molecular & Cellular Oncology er chaperone grp78 grp94 metaplasia mouse models pancreatic cancer |
| title | New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis |
| title_full | New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis |
| title_fullStr | New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis |
| title_full_unstemmed | New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis |
| title_short | New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis |
| title_sort | new role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis |
| topic | er chaperone grp78 grp94 metaplasia mouse models pancreatic cancer |
| url | http://dx.doi.org/10.1080/23723556.2017.1345350 |
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