Human plasmacytoid dendritic cells: from molecules to intercellular communication network
Plasmacytoid Dendritic Cells (pDCs) are a specific subset of naturally occurring dendritic cells, that secrete large amounts of Type I interferon and play an important role in the immune response against viral infection. Several studies have highlighted that they are also effective antigen presentin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00372/full |
| _version_ | 1819022134818635776 |
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| author | Till Sebastian Manuel Mathan Carl Gustav Figdor Sonja Ingrid Buschow |
| author_facet | Till Sebastian Manuel Mathan Carl Gustav Figdor Sonja Ingrid Buschow |
| author_sort | Till Sebastian Manuel Mathan |
| collection | DOAJ |
| description | Plasmacytoid Dendritic Cells (pDCs) are a specific subset of naturally occurring dendritic cells, that secrete large amounts of Type I interferon and play an important role in the immune response against viral infection. Several studies have highlighted that they are also effective antigen presenting cells (APCs), making them an interesting target for immunotherapy against cancer. However, the modes of action of pDCs are not restricted to antigen presentation and IFN secretion alone. In this review we will highlight a selection of cell surface proteins expressed by human pDCs that may facilitate communication with other immune cells, and we will discuss the implications of these molecules for pDC-driven immune responses. |
| first_indexed | 2024-12-21T04:18:10Z |
| format | Article |
| id | doaj.art-3210651de515416897a2d03ea3b2b001 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T04:18:10Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3210651de515416897a2d03ea3b2b0012022-12-21T19:16:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-11-01410.3389/fimmu.2013.0037268856Human plasmacytoid dendritic cells: from molecules to intercellular communication networkTill Sebastian Manuel Mathan0Carl Gustav Figdor1Sonja Ingrid Buschow2Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, NijmegenNijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, NijmegenNijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, NijmegenPlasmacytoid Dendritic Cells (pDCs) are a specific subset of naturally occurring dendritic cells, that secrete large amounts of Type I interferon and play an important role in the immune response against viral infection. Several studies have highlighted that they are also effective antigen presenting cells (APCs), making them an interesting target for immunotherapy against cancer. However, the modes of action of pDCs are not restricted to antigen presentation and IFN secretion alone. In this review we will highlight a selection of cell surface proteins expressed by human pDCs that may facilitate communication with other immune cells, and we will discuss the implications of these molecules for pDC-driven immune responses.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00372/fullMigrationCellular interactionviral infectionantigen presenting cell (APC)surface markersType I Interferons |
| spellingShingle | Till Sebastian Manuel Mathan Carl Gustav Figdor Sonja Ingrid Buschow Human plasmacytoid dendritic cells: from molecules to intercellular communication network Frontiers in Immunology Migration Cellular interaction viral infection antigen presenting cell (APC) surface markers Type I Interferons |
| title | Human plasmacytoid dendritic cells: from molecules to intercellular communication network |
| title_full | Human plasmacytoid dendritic cells: from molecules to intercellular communication network |
| title_fullStr | Human plasmacytoid dendritic cells: from molecules to intercellular communication network |
| title_full_unstemmed | Human plasmacytoid dendritic cells: from molecules to intercellular communication network |
| title_short | Human plasmacytoid dendritic cells: from molecules to intercellular communication network |
| title_sort | human plasmacytoid dendritic cells from molecules to intercellular communication network |
| topic | Migration Cellular interaction viral infection antigen presenting cell (APC) surface markers Type I Interferons |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00372/full |
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