Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus
Systemic Lupus Erythemathosus is an autoimmune, inflammatory, chronic disorder characterized by multiorgan system involvement. Depression and anxiety are frequent complaints among patients with lupus erythematosus, so antidepressive treatment should be an important element of the therapy of patient...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2017-04-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1105/836 |
| _version_ | 1819148892171665408 |
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| author | Maria Caecilia N. Setiawati Zullies Ikawati Kertia Nyoman |
| author_facet | Maria Caecilia N. Setiawati Zullies Ikawati Kertia Nyoman |
| author_sort | Maria Caecilia N. Setiawati |
| collection | DOAJ |
| description | Systemic Lupus Erythemathosus is an autoimmune, inflammatory, chronic disorder characterized by multiorgan system involvement. Depression and anxiety are frequent complaints among patients with lupus erythematosus, so antidepressive treatment should be an important element of the therapy of patients with lupus erythematosus. Research into curcumin’s potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. 4-weeks double-blind, placebo-controlled clinical trial was conducted in 14 SLE patients (10 as treatment group and 4 as control group) The BDI (Beck Depression Inventory) score was calculated and TNF α concentration was measured in the serum subjects before and after treatment. Correlation between TNF α concentration and BDI was assessed. After 4 weeks treatment, the TNF α concentration from subjects in treatment group were significantly lower than before ( p <0.001) but the BDI score were not significantly lower than before (p = 0.059). The TNF α concentration and BDI score showed positive correlation, p = 0,024. This study demonstrate that Curcuma xanthorrhiza Roxb extract can decrease serum TNF α concentration and reduce clinically symptoms of depression in SLE patients |
| first_indexed | 2024-12-22T13:52:56Z |
| format | Article |
| id | doaj.art-321067b759df484e9f5ba0e45bb01729 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-22T13:52:56Z |
| publishDate | 2017-04-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-321067b759df484e9f5ba0e45bb017292022-12-21T18:23:38ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862017-04-01283185190http://dx.doi.org/10.14499/indonesianjpharm28iss3pp185Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus ErythematosusMaria Caecilia N. Setiawati0Zullies Ikawati1Kertia Nyoman2College of Pharmacy Science Yayasan Farmasi Semarang 50193 IndonesiaFaculty of Pharmacy, Universitas Gadjah Mada , Yogyakarta 55281 IndonesiaFaculty of Medicine, Universitas Gadjah Mada Yogyakarta 55281 IndonesiaSystemic Lupus Erythemathosus is an autoimmune, inflammatory, chronic disorder characterized by multiorgan system involvement. Depression and anxiety are frequent complaints among patients with lupus erythematosus, so antidepressive treatment should be an important element of the therapy of patients with lupus erythematosus. Research into curcumin’s potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. 4-weeks double-blind, placebo-controlled clinical trial was conducted in 14 SLE patients (10 as treatment group and 4 as control group) The BDI (Beck Depression Inventory) score was calculated and TNF α concentration was measured in the serum subjects before and after treatment. Correlation between TNF α concentration and BDI was assessed. After 4 weeks treatment, the TNF α concentration from subjects in treatment group were significantly lower than before ( p <0.001) but the BDI score were not significantly lower than before (p = 0.059). The TNF α concentration and BDI score showed positive correlation, p = 0,024. This study demonstrate that Curcuma xanthorrhiza Roxb extract can decrease serum TNF α concentration and reduce clinically symptoms of depression in SLE patientshttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1105/836Curcuma xanthorrhiza Roxb. ExtractSystemic Lupus ErythematosusTumor Necrosis Factor αBeck Depression Inventory |
| spellingShingle | Maria Caecilia N. Setiawati Zullies Ikawati Kertia Nyoman Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus Indonesian Journal of Pharmacy Curcuma xanthorrhiza Roxb. Extract Systemic Lupus Erythematosus Tumor Necrosis Factor α Beck Depression Inventory |
| title | Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus |
| title_full | Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus |
| title_fullStr | Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus |
| title_full_unstemmed | Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus |
| title_short | Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus |
| title_sort | antiinflamatory and antidepressive activities of extract curcuma xanthorrhiza roxb in systemic lupus erythematosus |
| topic | Curcuma xanthorrhiza Roxb. Extract Systemic Lupus Erythematosus Tumor Necrosis Factor α Beck Depression Inventory |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1105/836 |
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