Type I Kounis syndrome variant: A case report and literature review
Kounis syndrome defined as the occurrence of acute coronary syndrome in the setting of allergic reaction due to mast cells activation and inflammatory mediators release that induces coronary vasospasm, plaque erosion, or even stent thrombosis. A 25-year-old postpartum female with asthma and recurren...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2018-01-01
|
| Series: | Avicenna Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_114_17 |
| _version_ | 1818342688286572544 |
|---|---|
| author | Abdullah Haddad Triston Smith Aneel Bole Moneal Shah Mithun Chakravarthy |
| author_facet | Abdullah Haddad Triston Smith Aneel Bole Moneal Shah Mithun Chakravarthy |
| author_sort | Abdullah Haddad |
| collection | DOAJ |
| description | Kounis syndrome defined as the occurrence of acute coronary syndrome in the setting of allergic reaction due to mast cells activation and inflammatory mediators release that induces coronary vasospasm, plaque erosion, or even stent thrombosis. A 25-year-old postpartum female with asthma and recurrent episodes of chest pain was admitted with ST-segment elevation myocardial infarction in the setting of coronary artery spasms. The patient was started on calcium channel blockers and nitrite-based medication with no improvement. She was noted to have eosinophilia and initiation of corticosteroid-based regimen lead to resolution of chest pain episodes and normalization of eosinophilia. Kounis syndrome should be considered in young patients with chest pain. Coronary vasodilators are considered as the first-line of treatment. The use of corticosteroids has been described in the literature in severe or refractory cases. |
| first_indexed | 2024-12-13T16:18:40Z |
| format | Article |
| id | doaj.art-32119b8883b74899925245c771b1c93d |
| institution | Directory Open Access Journal |
| issn | 2231-0770 2249-4464 |
| language | English |
| last_indexed | 2024-12-13T16:18:40Z |
| publishDate | 2018-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Avicenna Journal of Medicine |
| spelling | doaj.art-32119b8883b74899925245c771b1c93d2022-12-21T23:38:47ZengThieme Medical and Scientific Publishers Pvt. Ltd.Avicenna Journal of Medicine2231-07702249-44642018-01-01801373910.4103/ajm.AJM_114_17Type I Kounis syndrome variant: A case report and literature reviewAbdullah Haddad0Triston Smith1Aneel Bole2Moneal Shah3Mithun Chakravarthy4Department of Internal Medicine, Saint Clair Memorial Hospital, Allegheny General Hospital, Pittsburgh, PA, USADepartment of Internal Medicine, Saint Clair Memorial Hospital, Allegheny General Hospital, Pittsburgh, PA, USADepartment of Internal Medicine, Saint Clair Memorial Hospital, Allegheny General Hospital, Pittsburgh, PA, USADepartment of Internal Medicine, Saint Clair Memorial Hospital, Allegheny General Hospital, Pittsburgh, PA, USADepartment of Internal Medicine, Saint Clair Memorial Hospital, Allegheny General Hospital, Pittsburgh, PA, USAKounis syndrome defined as the occurrence of acute coronary syndrome in the setting of allergic reaction due to mast cells activation and inflammatory mediators release that induces coronary vasospasm, plaque erosion, or even stent thrombosis. A 25-year-old postpartum female with asthma and recurrent episodes of chest pain was admitted with ST-segment elevation myocardial infarction in the setting of coronary artery spasms. The patient was started on calcium channel blockers and nitrite-based medication with no improvement. She was noted to have eosinophilia and initiation of corticosteroid-based regimen lead to resolution of chest pain episodes and normalization of eosinophilia. Kounis syndrome should be considered in young patients with chest pain. Coronary vasodilators are considered as the first-line of treatment. The use of corticosteroids has been described in the literature in severe or refractory cases.http://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_114_17allergic coronary artery syndromecoronary artery vasospasmkounis syndrome |
| spellingShingle | Abdullah Haddad Triston Smith Aneel Bole Moneal Shah Mithun Chakravarthy Type I Kounis syndrome variant: A case report and literature review Avicenna Journal of Medicine allergic coronary artery syndrome coronary artery vasospasm kounis syndrome |
| title | Type I Kounis syndrome variant: A case report and literature review |
| title_full | Type I Kounis syndrome variant: A case report and literature review |
| title_fullStr | Type I Kounis syndrome variant: A case report and literature review |
| title_full_unstemmed | Type I Kounis syndrome variant: A case report and literature review |
| title_short | Type I Kounis syndrome variant: A case report and literature review |
| title_sort | type i kounis syndrome variant a case report and literature review |
| topic | allergic coronary artery syndrome coronary artery vasospasm kounis syndrome |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_114_17 |
| work_keys_str_mv | AT abdullahhaddad typeikounissyndromevariantacasereportandliteraturereview AT tristonsmith typeikounissyndromevariantacasereportandliteraturereview AT aneelbole typeikounissyndromevariantacasereportandliteraturereview AT monealshah typeikounissyndromevariantacasereportandliteraturereview AT mithunchakravarthy typeikounissyndromevariantacasereportandliteraturereview |