Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution Width
Background: Meta-analysis has found that high baseline red blood cell distribution width (RDW) is associated with increased long-term mortality (mortality at one year or more) in ischemic stroke. The objectives of this study were to determine whether there is an association between RDW and 30-day mo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/4/196 |
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| author | Leonardo Lorente María M. Martín Pedro Abreu-González Antonia Pérez-Cejas Agustín F. González-Rivero Luis Ramos-Gómez Mónica Argueso Jordi Solé-Violán Juan J. Cáceres Alejandro Jiménez Victor García-Marín |
| author_facet | Leonardo Lorente María M. Martín Pedro Abreu-González Antonia Pérez-Cejas Agustín F. González-Rivero Luis Ramos-Gómez Mónica Argueso Jordi Solé-Violán Juan J. Cáceres Alejandro Jiménez Victor García-Marín |
| author_sort | Leonardo Lorente |
| collection | DOAJ |
| description | Background: Meta-analysis has found that high baseline red blood cell distribution width (RDW) is associated with increased long-term mortality (mortality at one year or more) in ischemic stroke. The objectives of this study were to determine whether there is an association between RDW and 30-day mortality, and to explore whether RDW during the first week of ischemic stroke could be a 30-day mortality biomarker. Methods: We included patients with malignant middle cerebral artery infarction (MMCAI). RDW at days 1, 4, and 8 of MMCAI were determined. The end-point study was 30-day mortality. Results: We found that survivor (<i>n</i> = 37) in respect to non-survivor patients (<i>n</i> = 37) had lower RDW at days 1 (<i>p</i><i> </i>< 0.001), 4 (<i>p</i><i> </i>< 0.001), and 8 (<i>p</i><i> </i>= 0.02). The area under curve (95% CI) for prediction of 30-day mortality by RDW at days 1, 4, and 8 of MMCAI were 0.80 (0.69−0.89; p < 0.001), 0.79 (0.66−0.89; p < 0.001), and 0.73 (0.58−0.84; p = 0.02). Regression analysis showed an association between RDW (odds ratio = 1.695; 95% CI = 1.230−2.335; <i>p</i><i> </i>< 0.001) and 30-day mortality. Conclusions: The association between RDW and early mortality, and the potential role of RDW during the first week of MMCAI as a prognostic biomarker of early mortality were the main novelties of our study. |
| first_indexed | 2024-04-12T21:47:11Z |
| format | Article |
| id | doaj.art-3213da114db5494d8c7ba6eb9da53317 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-04-12T21:47:11Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-3213da114db5494d8c7ba6eb9da533172022-12-22T03:15:35ZengMDPI AGBrain Sciences2076-34252020-03-0110419610.3390/brainsci10040196brainsci10040196Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution WidthLeonardo Lorente0María M. Martín1Pedro Abreu-González2Antonia Pérez-Cejas3Agustín F. González-Rivero4Luis Ramos-Gómez5Mónica Argueso6Jordi Solé-Violán7Juan J. Cáceres8Alejandro Jiménez9Victor García-Marín10Intensive Care Unit, Hospital Universitario de Canarias, Ofra s/n, La Laguna, 38320 Santa Cruz de Tenerife, SpainIntensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, Crta del Rosario s/n, 38010 Santa Cruz de Tenerife, SpainDepartment of Physiology, Faculty of Medicine, University of the La Laguna, Ofra s/n, La Laguna, 38320 Santa Cruz de Tenerife, SpainLaboratory Department, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320 Santa Cruz de Tenerife, SpainLaboratory Department, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320 Santa Cruz de Tenerife, SpainIntensive Care Unit, Hospital General La Palma, Buenavista de Arriba s/n, Breña Alta, 38713 La Palma, SpainIntensive Care Unit, Hospital Clínico Universitario de Valencia, Avda, Blasco Ibáñez n°17-19, 46004 Valencia, SpainIntensive Care Unit, Hospital Universitario Dr. Negrín, CIBERES, Barranco de la Ballena s/n, 35010 Las Palmas de Gran Canaria, SpainIntensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, SpainResearch Unit, Hospital Universitario de Canarias, Ofra s/n, La Laguna, 38320 Santa Cruz de Tenerife, SpainDepartment of Neurosurgery, Hospital Universitario de Canarias, Ofra, s/n, 38320 La Laguna, Santa Cruz de Tenerife, SpainBackground: Meta-analysis has found that high baseline red blood cell distribution width (RDW) is associated with increased long-term mortality (mortality at one year or more) in ischemic stroke. The objectives of this study were to determine whether there is an association between RDW and 30-day mortality, and to explore whether RDW during the first week of ischemic stroke could be a 30-day mortality biomarker. Methods: We included patients with malignant middle cerebral artery infarction (MMCAI). RDW at days 1, 4, and 8 of MMCAI were determined. The end-point study was 30-day mortality. Results: We found that survivor (<i>n</i> = 37) in respect to non-survivor patients (<i>n</i> = 37) had lower RDW at days 1 (<i>p</i><i> </i>< 0.001), 4 (<i>p</i><i> </i>< 0.001), and 8 (<i>p</i><i> </i>= 0.02). The area under curve (95% CI) for prediction of 30-day mortality by RDW at days 1, 4, and 8 of MMCAI were 0.80 (0.69−0.89; p < 0.001), 0.79 (0.66−0.89; p < 0.001), and 0.73 (0.58−0.84; p = 0.02). Regression analysis showed an association between RDW (odds ratio = 1.695; 95% CI = 1.230−2.335; <i>p</i><i> </i>< 0.001) and 30-day mortality. Conclusions: The association between RDW and early mortality, and the potential role of RDW during the first week of MMCAI as a prognostic biomarker of early mortality were the main novelties of our study.https://www.mdpi.com/2076-3425/10/4/196red blood cell distribution widthbrain infarctionpatientsmortalityprognosis |
| spellingShingle | Leonardo Lorente María M. Martín Pedro Abreu-González Antonia Pérez-Cejas Agustín F. González-Rivero Luis Ramos-Gómez Mónica Argueso Jordi Solé-Violán Juan J. Cáceres Alejandro Jiménez Victor García-Marín Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution Width Brain Sciences red blood cell distribution width brain infarction patients mortality prognosis |
| title | Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution Width |
| title_full | Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution Width |
| title_fullStr | Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution Width |
| title_full_unstemmed | Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution Width |
| title_short | Early Mortality of Brain Infarction Patients and Red Blood Cell Distribution Width |
| title_sort | early mortality of brain infarction patients and red blood cell distribution width |
| topic | red blood cell distribution width brain infarction patients mortality prognosis |
| url | https://www.mdpi.com/2076-3425/10/4/196 |
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