Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential
The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922007546 |
| _version_ | 1797991812160290816 |
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| author | Masaya Togo Riki Matsumoto Kiyohide Usami Katsuya Kobayashi Hirofumi Takeyama Takuro Nakae Akihiro Shimotake Takayuki Kikuchi Kazumichi Yoshida Masao Matsuhashi Takeharu Kunieda Susumu Miyamoto Ryosuke Takahashi Akio Ikeda |
| author_facet | Masaya Togo Riki Matsumoto Kiyohide Usami Katsuya Kobayashi Hirofumi Takeyama Takuro Nakae Akihiro Shimotake Takayuki Kikuchi Kazumichi Yoshida Masao Matsuhashi Takeharu Kunieda Susumu Miyamoto Ryosuke Takahashi Akio Ikeda |
| author_sort | Masaya Togo |
| collection | DOAJ |
| description | The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal cortices, and these differences have not yet been precisely elucidated. Electrophysiological connectivity is essential for understanding cortical function or functional differences. Since little is known about electrophysiological connections from the medial parietal cortices in humans, we evaluated distinct connectivity patterns in the medial parietal cortices by constructing a standardized connectivity map using cortico-cortical evoked potential (CCEP). This study included nine patients with partial epilepsy or a brain tumor who underwent chronic intracranial electrode placement covering the medial parietal cortices. Single-pulse electrical stimuli were delivered to the medial parietal cortices (38 pairs of electrodes). Responses were standardized using the z-score of the baseline activity, and a response density map was constructed in the Montreal Neurological Institutes (MNI) space. The precuneus tended to connect with the inferior parietal lobule (IPL), the occipital cortex, superior parietal lobule (SPL), and the dorsal premotor area (PMd) (the four most active regions, in descending order), while the dPCC tended to connect to the middle cingulate cortex, SPL, precuneus, and IPL. The connectivity pattern differs significantly between the precuneus and dPCC stimulation (p<0.05). Regarding each part of the medial parietal cortices, the distributions of parts of CCEP responses resembled those of the functional connectivity database. Based on how the dPCC was connected to the medial frontal area, SPL, and IPL, its connectivity pattern could not be explained by DMN alone, but suggested a mixture of DMN and the frontoparietal cognitive network. These findings improve our understanding of the connectivity profile within the medial parietal cortices. The electrophysiological connectivity is the basis of propagation of electrical activities in patients with epilepsy. In addition, it helps us to better understand the epileptic network arising from the medial parietal cortices. |
| first_indexed | 2024-04-11T08:56:59Z |
| format | Article |
| id | doaj.art-3213dffa6df444ce9f3c28bbccca82d9 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-11T08:56:59Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-3213dffa6df444ce9f3c28bbccca82d92022-12-22T04:33:09ZengElsevierNeuroImage1095-95722022-11-01263119639Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potentialMasaya Togo0Riki Matsumoto1Kiyohide Usami2Katsuya Kobayashi3Hirofumi Takeyama4Takuro Nakae5Akihiro Shimotake6Takayuki Kikuchi7Kazumichi Yoshida8Masao Matsuhashi9Takeharu Kunieda10Susumu Miyamoto11Ryosuke Takahashi12Akio Ikeda13Department of Neurology, Kyoto University Graduate School of Medicine, Japan; Division of Neurology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, JapanDepartment of Neurology, Kyoto University Graduate School of Medicine, Japan; Division of Neurology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan; Corresponding author. Division of Neurology, Kobe University Graduate School of Medicine, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.Department of Neurology, Kyoto University Graduate School of Medicine, JapanDepartment of Neurology, Kyoto University Graduate School of Medicine, JapanDepartment of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Japan; Department of Neurology, Japanese Red Cross Otsu Hospital, JapanDepartment of Neurosurgery, Shiga General Hospital, JapanDepartment of Neurology, Kyoto University Graduate School of Medicine, JapanDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, JapanDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, JapanDepartments of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, JapanDepartment of Neurosurgery, Ehime University Graduate School of Medicine, JapanDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, JapanDepartment of Neurology, Kyoto University Graduate School of Medicine, JapanDepartments of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan; Co–Corresponding author. Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto University Hospital, 54 Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal cortices, and these differences have not yet been precisely elucidated. Electrophysiological connectivity is essential for understanding cortical function or functional differences. Since little is known about electrophysiological connections from the medial parietal cortices in humans, we evaluated distinct connectivity patterns in the medial parietal cortices by constructing a standardized connectivity map using cortico-cortical evoked potential (CCEP). This study included nine patients with partial epilepsy or a brain tumor who underwent chronic intracranial electrode placement covering the medial parietal cortices. Single-pulse electrical stimuli were delivered to the medial parietal cortices (38 pairs of electrodes). Responses were standardized using the z-score of the baseline activity, and a response density map was constructed in the Montreal Neurological Institutes (MNI) space. The precuneus tended to connect with the inferior parietal lobule (IPL), the occipital cortex, superior parietal lobule (SPL), and the dorsal premotor area (PMd) (the four most active regions, in descending order), while the dPCC tended to connect to the middle cingulate cortex, SPL, precuneus, and IPL. The connectivity pattern differs significantly between the precuneus and dPCC stimulation (p<0.05). Regarding each part of the medial parietal cortices, the distributions of parts of CCEP responses resembled those of the functional connectivity database. Based on how the dPCC was connected to the medial frontal area, SPL, and IPL, its connectivity pattern could not be explained by DMN alone, but suggested a mixture of DMN and the frontoparietal cognitive network. These findings improve our understanding of the connectivity profile within the medial parietal cortices. The electrophysiological connectivity is the basis of propagation of electrical activities in patients with epilepsy. In addition, it helps us to better understand the epileptic network arising from the medial parietal cortices.http://www.sciencedirect.com/science/article/pii/S1053811922007546Medial parietal corticesPosterior cingulate cortexPrecuneusDefault mode networkCortico-cortical evoked potential (CCEP) |
| spellingShingle | Masaya Togo Riki Matsumoto Kiyohide Usami Katsuya Kobayashi Hirofumi Takeyama Takuro Nakae Akihiro Shimotake Takayuki Kikuchi Kazumichi Yoshida Masao Matsuhashi Takeharu Kunieda Susumu Miyamoto Ryosuke Takahashi Akio Ikeda Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential NeuroImage Medial parietal cortices Posterior cingulate cortex Precuneus Default mode network Cortico-cortical evoked potential (CCEP) |
| title | Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential |
| title_full | Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential |
| title_fullStr | Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential |
| title_full_unstemmed | Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential |
| title_short | Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential |
| title_sort | distinct connectivity patterns in human medial parietal cortices evidence from standardized connectivity map using cortico cortical evoked potential |
| topic | Medial parietal cortices Posterior cingulate cortex Precuneus Default mode network Cortico-cortical evoked potential (CCEP) |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922007546 |
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