Orthopedic Surgeons’ Views of Hyaluronic Acid Formulations in the Management of Knee Osteoarthritis: A Questionnaire-Based Cross-Sectional Study
<i>Background and Objectives</i><b>:</b> Multiple hyaluronic acid (HA) products were approved and marketed to manage osteoarthritis (OA). Although these products are widely prescribed by orthopedic surgeons to manage OA, especially knee OA, the therapeutic value of these prod...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/9/990 |
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| author | Shahd Alnasser Fatima AlHussain Hassan Asiri Abdullah Almutairi Hisham Alsanawi Anas AR Altamimi Yousif A. Asiri Omar A. Almohammed Yazed AlRuthia |
| author_facet | Shahd Alnasser Fatima AlHussain Hassan Asiri Abdullah Almutairi Hisham Alsanawi Anas AR Altamimi Yousif A. Asiri Omar A. Almohammed Yazed AlRuthia |
| author_sort | Shahd Alnasser |
| collection | DOAJ |
| description | <i>Background and Objectives</i><b>:</b> Multiple hyaluronic acid (HA) products were approved and marketed to manage osteoarthritis (OA). Although these products are widely prescribed by orthopedic surgeons to manage OA, especially knee OA, the therapeutic value of these products is highly uncertain. Few studies with significant limitations in their designs have indicated positive outcomes among OA patients treated with HA; however, their results were inconclusive. Thus, we aimed to explore the therapeutic value of different HA products in alleviating knee OA pain and improving patients’ physical function from the orthopedic surgeons’ perspective. <i>Materials and Methods</i>: This was a questionnaire-based cross-sectional study in which practicing orthopedic surgeons in two countries (e.g., Saudi Arabia and Jordan) were invited to participate. The 10-item, newly developed questionnaire inquired about the respondents’ sociodemographic characteristics (e.g., age, gender, country, years of experience), and their opinions regarding the efficacy of HA products in the management of OA (e.g., efficacy in improving mobility and alleviating pain). <i>Results</i>: Out of the 200 orthopedic surgeons who were invited to participate, 122 (61%) filled out the questionnaire. Most of the respondents were from Saudi Arabia (58%), aged 35 to 55 years (68%), had at least 10 years of experience (69%), and male (98%). About 80% of the respondents reported prescribing HA, such as Hyalgan<sup>®</sup>, Orthovisc<sup>®</sup>, Hyalubrix<sup>®</sup>, and Crespine Gel<sup>®</sup>. About 66% of the respondents believed that HA was moderately to highly effective in managing knee OA, and 34% believed that HA was either ineffective or mildly effective. Pain at the site of injection (44.3%) and rash or local skin reactions (22.1%) were the most commonly reported adverse events. <i>Conclusions</i>: The variations in the formulation of different HA brands (e.g., molecular weight and cross-linking) did not seem to offer any therapeutic advantage. HA might have value in the management of knee OA; however, its value is highly uncertain and necessitates more well-designed studies to further examine its therapeutic value. |
| first_indexed | 2024-03-10T07:26:48Z |
| format | Article |
| id | doaj.art-3214df94bfed40628155716e62cd4de8 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T07:26:48Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-3214df94bfed40628155716e62cd4de82023-11-22T14:09:25ZengMDPI AGMedicina1010-660X1648-91442021-09-0157999010.3390/medicina57090990Orthopedic Surgeons’ Views of Hyaluronic Acid Formulations in the Management of Knee Osteoarthritis: A Questionnaire-Based Cross-Sectional StudyShahd Alnasser0Fatima AlHussain1Hassan Asiri2Abdullah Almutairi3Hisham Alsanawi4Anas AR Altamimi5Yousif A. Asiri6Omar A. Almohammed7Yazed AlRuthia8Department of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi ArabiaDepartment of Pharmacoeconomics and Drug Pricing, Saudi Food and Drug, Authority, P.O. Box 84983, Riyadh 11681, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi ArabiaDepartment of Orthopedic Surgery, College of Medicine, King Saud University, P.O. Box 3145, Riyadh 12372, Saudi ArabiaDepartment of General and Special Surgery, Faculty of Medicine, Hashemite University, P.O. Box 921113, Amman 11192, JordanDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2454, Riyadh 11451, Saudi Arabia<i>Background and Objectives</i><b>:</b> Multiple hyaluronic acid (HA) products were approved and marketed to manage osteoarthritis (OA). Although these products are widely prescribed by orthopedic surgeons to manage OA, especially knee OA, the therapeutic value of these products is highly uncertain. Few studies with significant limitations in their designs have indicated positive outcomes among OA patients treated with HA; however, their results were inconclusive. Thus, we aimed to explore the therapeutic value of different HA products in alleviating knee OA pain and improving patients’ physical function from the orthopedic surgeons’ perspective. <i>Materials and Methods</i>: This was a questionnaire-based cross-sectional study in which practicing orthopedic surgeons in two countries (e.g., Saudi Arabia and Jordan) were invited to participate. The 10-item, newly developed questionnaire inquired about the respondents’ sociodemographic characteristics (e.g., age, gender, country, years of experience), and their opinions regarding the efficacy of HA products in the management of OA (e.g., efficacy in improving mobility and alleviating pain). <i>Results</i>: Out of the 200 orthopedic surgeons who were invited to participate, 122 (61%) filled out the questionnaire. Most of the respondents were from Saudi Arabia (58%), aged 35 to 55 years (68%), had at least 10 years of experience (69%), and male (98%). About 80% of the respondents reported prescribing HA, such as Hyalgan<sup>®</sup>, Orthovisc<sup>®</sup>, Hyalubrix<sup>®</sup>, and Crespine Gel<sup>®</sup>. About 66% of the respondents believed that HA was moderately to highly effective in managing knee OA, and 34% believed that HA was either ineffective or mildly effective. Pain at the site of injection (44.3%) and rash or local skin reactions (22.1%) were the most commonly reported adverse events. <i>Conclusions</i>: The variations in the formulation of different HA brands (e.g., molecular weight and cross-linking) did not seem to offer any therapeutic advantage. HA might have value in the management of knee OA; however, its value is highly uncertain and necessitates more well-designed studies to further examine its therapeutic value.https://www.mdpi.com/1648-9144/57/9/990hyaluronic acidorthopedicsosteoarthritispain managementMiddle East |
| spellingShingle | Shahd Alnasser Fatima AlHussain Hassan Asiri Abdullah Almutairi Hisham Alsanawi Anas AR Altamimi Yousif A. Asiri Omar A. Almohammed Yazed AlRuthia Orthopedic Surgeons’ Views of Hyaluronic Acid Formulations in the Management of Knee Osteoarthritis: A Questionnaire-Based Cross-Sectional Study Medicina hyaluronic acid orthopedics osteoarthritis pain management Middle East |
| title | Orthopedic Surgeons’ Views of Hyaluronic Acid Formulations in the Management of Knee Osteoarthritis: A Questionnaire-Based Cross-Sectional Study |
| title_full | Orthopedic Surgeons’ Views of Hyaluronic Acid Formulations in the Management of Knee Osteoarthritis: A Questionnaire-Based Cross-Sectional Study |
| title_fullStr | Orthopedic Surgeons’ Views of Hyaluronic Acid Formulations in the Management of Knee Osteoarthritis: A Questionnaire-Based Cross-Sectional Study |
| title_full_unstemmed | Orthopedic Surgeons’ Views of Hyaluronic Acid Formulations in the Management of Knee Osteoarthritis: A Questionnaire-Based Cross-Sectional Study |
| title_short | Orthopedic Surgeons’ Views of Hyaluronic Acid Formulations in the Management of Knee Osteoarthritis: A Questionnaire-Based Cross-Sectional Study |
| title_sort | orthopedic surgeons views of hyaluronic acid formulations in the management of knee osteoarthritis a questionnaire based cross sectional study |
| topic | hyaluronic acid orthopedics osteoarthritis pain management Middle East |
| url | https://www.mdpi.com/1648-9144/57/9/990 |
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