The Impact of Advanced Maternal Age on Neonatal Outcome in Preterm Births before 34 Weeks
Background: In recent years a trend towards childbearing at older maternal age is evident. Most of the current literature investigated the association between advanced maternal age and neonatal outcome at term. We aimed to study the outcomes of the mother and the neonate among preterm births of wome...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-09-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009191 |
| _version_ | 1827798054929956864 |
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| author | Daniel Tairy Ohad Gluck Yakira Izaik Jacob Bar Eran Weiner Giulia Barda |
| author_facet | Daniel Tairy Ohad Gluck Yakira Izaik Jacob Bar Eran Weiner Giulia Barda |
| author_sort | Daniel Tairy |
| collection | DOAJ |
| description | Background: In recent years a trend towards childbearing at older maternal age is evident. Most of the current literature investigated the association between advanced maternal age and neonatal outcome at term. We aimed to study the outcomes of the mother and the neonate among preterm births of women of advanced maternal age. Methods: This retrospective study between 2009 to 2017, comprised 494 singleton preterm births between 24 and 34 weeks gestation, of which 116 (23%) were of 35 years old or older (advanced maternal age) and 378 (77%) were of younger women. The medical records were reviewed and the outcomes of the mother and the neonate were compared between advanced maternal age (≥35 years) and younger women. Results: The rate of severe intra-ventricular hemorrhage (IVH) and of composite adverse neonatal outcome was lower among advanced maternal age women compared to younger women (p = 0.02 and p = 0.05 respectively). In multivariate regression analysis, composite adverse neonatal outcome was found to be independently inversely associated only with advanced maternal age (adjusted odds ratio (aOR) 0.45 95% confidence interval (CI) 0.23–0.86). Conclusions: Advanced maternal age was not found to be a risk factor for adverse neonatal outcome among preterm births before 34 weeks, and might be a protective factor from early neonatal complications. |
| first_indexed | 2024-03-11T19:30:34Z |
| format | Article |
| id | doaj.art-3216c69eb9084c63993a32055d5340c4 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-11T19:30:34Z |
| publishDate | 2023-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-3216c69eb9084c63993a32055d5340c42023-10-06T13:17:09ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-09-0150919110.31083/j.ceog5009191S0390-6663(23)02146-2The Impact of Advanced Maternal Age on Neonatal Outcome in Preterm Births before 34 WeeksDaniel Tairy0Ohad Gluck1Yakira Izaik2Jacob Bar3Eran Weiner4Giulia Barda5Department of Obstetrics & Gynecology, the Edith Wolfson Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, 5822012 Tel Aviv, IsraelDepartment of Obstetrics & Gynecology, the Edith Wolfson Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, 5822012 Tel Aviv, IsraelDepartment of Obstetrics & Gynecology, the Edith Wolfson Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, 5822012 Tel Aviv, IsraelDepartment of Obstetrics & Gynecology, the Edith Wolfson Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, 5822012 Tel Aviv, IsraelDepartment of Obstetrics & Gynecology, the Edith Wolfson Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, 5822012 Tel Aviv, IsraelDepartment of Obstetrics & Gynecology, the Edith Wolfson Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, 5822012 Tel Aviv, IsraelBackground: In recent years a trend towards childbearing at older maternal age is evident. Most of the current literature investigated the association between advanced maternal age and neonatal outcome at term. We aimed to study the outcomes of the mother and the neonate among preterm births of women of advanced maternal age. Methods: This retrospective study between 2009 to 2017, comprised 494 singleton preterm births between 24 and 34 weeks gestation, of which 116 (23%) were of 35 years old or older (advanced maternal age) and 378 (77%) were of younger women. The medical records were reviewed and the outcomes of the mother and the neonate were compared between advanced maternal age (≥35 years) and younger women. Results: The rate of severe intra-ventricular hemorrhage (IVH) and of composite adverse neonatal outcome was lower among advanced maternal age women compared to younger women (p = 0.02 and p = 0.05 respectively). In multivariate regression analysis, composite adverse neonatal outcome was found to be independently inversely associated only with advanced maternal age (adjusted odds ratio (aOR) 0.45 95% confidence interval (CI) 0.23–0.86). Conclusions: Advanced maternal age was not found to be a risk factor for adverse neonatal outcome among preterm births before 34 weeks, and might be a protective factor from early neonatal complications.https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009191advanced maternal age womenpreterm birthmaternal outcomeneonatal outcome |
| spellingShingle | Daniel Tairy Ohad Gluck Yakira Izaik Jacob Bar Eran Weiner Giulia Barda The Impact of Advanced Maternal Age on Neonatal Outcome in Preterm Births before 34 Weeks Clinical and Experimental Obstetrics & Gynecology advanced maternal age women preterm birth maternal outcome neonatal outcome |
| title | The Impact of Advanced Maternal Age on Neonatal Outcome in Preterm Births before 34 Weeks |
| title_full | The Impact of Advanced Maternal Age on Neonatal Outcome in Preterm Births before 34 Weeks |
| title_fullStr | The Impact of Advanced Maternal Age on Neonatal Outcome in Preterm Births before 34 Weeks |
| title_full_unstemmed | The Impact of Advanced Maternal Age on Neonatal Outcome in Preterm Births before 34 Weeks |
| title_short | The Impact of Advanced Maternal Age on Neonatal Outcome in Preterm Births before 34 Weeks |
| title_sort | impact of advanced maternal age on neonatal outcome in preterm births before 34 weeks |
| topic | advanced maternal age women preterm birth maternal outcome neonatal outcome |
| url | https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009191 |
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