Voclosporin: Unique Chemistry, Pharmacology and Toxicity Profile, and Possible Options for Implementation into the Management of Lupus Nephritis

Voclosporin: Unique Chemistry, Pharmacology and Toxicity Profile, and Possible Options for Implementation into the Management of Lupus Nephritis

Calcineurin inhibitors (CNI) can suppress allo- and autoimmunity by suppressing T cell function but also have anti-proteinuric effects by stabilizing the cellular components of the kidney’s filtration barrier. Therefore, CNI are used in autoimmune kidney diseases with proteinuria. However, the tradi...

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Bibliographic Details
Main Authors: Ajinath Kale, Vishwadeep Shelke, Yutian Lei, Anil Bhanudas Gaikwad, Hans-Joachim Anders
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
calcineurin
autoimmunity
inflammation
proteinuria
podocytes
toxicity
Online Access:https://www.mdpi.com/2073-4409/12/20/2440

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