The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis
Spondyloarthritis (SpA) is a subset of seronegative rheumatic-related autoimmune diseases that consist of ankylosing spondylitis (AS), psoriatic spondylitis (PsA), reactive spondylitis (re-SpA), inflammatory bowel disease (IBD)-associated spondylitis, and unclassifiable spondylitis. These subsets sh...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6401 |
| _version_ | 1797554691599499264 |
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| author | Hiroyuki Tsukazaki Takashi Kaito |
| author_facet | Hiroyuki Tsukazaki Takashi Kaito |
| author_sort | Hiroyuki Tsukazaki |
| collection | DOAJ |
| description | Spondyloarthritis (SpA) is a subset of seronegative rheumatic-related autoimmune diseases that consist of ankylosing spondylitis (AS), psoriatic spondylitis (PsA), reactive spondylitis (re-SpA), inflammatory bowel disease (IBD)-associated spondylitis, and unclassifiable spondylitis. These subsets share clinical phenotypes such as joint inflammation and extra-articular manifestations (uveitis, IBD, and psoriasis [Ps]). Inflammation at the enthesis, where ligaments and tendons attach to bones, characterizes and distinguishes SpA from other types of arthritis. Over the past several years, genetic, experimental, and clinical studies have accumulated evidence showing that the IL-23/IL-17 axis plays a critical role in the pathogenesis of SpA. These discoveries include genetic association and the identification of IL-23- and IL-17-producing cells in the tissue of mouse models and human patients. In this review, we summarize the current knowledge of the pathomechanism by focusing on the IL-23/IL-17 pathway and examine the recent clinical studies of biological agents targeting IL-23 and IL-17 in the treatment of SpA. |
| first_indexed | 2024-03-10T16:36:37Z |
| format | Article |
| id | doaj.art-321a051a473c42d0810b03cdd67da3dc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:36:37Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-321a051a473c42d0810b03cdd67da3dc2023-11-20T12:23:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012117640110.3390/ijms21176401The Role of the IL-23/IL-17 Pathway in the Pathogenesis of SpondyloarthritisHiroyuki Tsukazaki0Takashi Kaito1Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanSpondyloarthritis (SpA) is a subset of seronegative rheumatic-related autoimmune diseases that consist of ankylosing spondylitis (AS), psoriatic spondylitis (PsA), reactive spondylitis (re-SpA), inflammatory bowel disease (IBD)-associated spondylitis, and unclassifiable spondylitis. These subsets share clinical phenotypes such as joint inflammation and extra-articular manifestations (uveitis, IBD, and psoriasis [Ps]). Inflammation at the enthesis, where ligaments and tendons attach to bones, characterizes and distinguishes SpA from other types of arthritis. Over the past several years, genetic, experimental, and clinical studies have accumulated evidence showing that the IL-23/IL-17 axis plays a critical role in the pathogenesis of SpA. These discoveries include genetic association and the identification of IL-23- and IL-17-producing cells in the tissue of mouse models and human patients. In this review, we summarize the current knowledge of the pathomechanism by focusing on the IL-23/IL-17 pathway and examine the recent clinical studies of biological agents targeting IL-23 and IL-17 in the treatment of SpA.https://www.mdpi.com/1422-0067/21/17/6401Spondyloarthritisankylosing arthritispsoriatic arthritisinterleukin-17interleukin-23 |
| spellingShingle | Hiroyuki Tsukazaki Takashi Kaito The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis International Journal of Molecular Sciences Spondyloarthritis ankylosing arthritis psoriatic arthritis interleukin-17 interleukin-23 |
| title | The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis |
| title_full | The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis |
| title_fullStr | The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis |
| title_full_unstemmed | The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis |
| title_short | The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis |
| title_sort | role of the il 23 il 17 pathway in the pathogenesis of spondyloarthritis |
| topic | Spondyloarthritis ankylosing arthritis psoriatic arthritis interleukin-17 interleukin-23 |
| url | https://www.mdpi.com/1422-0067/21/17/6401 |
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