Total Flavonoids of Drynariae Rhizoma Improve Glucocorticoid-Induced Osteoporosis of Rats: UHPLC-MS-Based Qualitative Analysis, Network Pharmacology Strategy and Pharmacodynamic Validation

Total Flavonoids of Drynariae Rhizoma Improve Glucocorticoid-Induced Osteoporosis of Rats: UHPLC-MS-Based Qualitative Analysis, Network Pharmacology Strategy and Pharmacodynamic Validation

BackgroundGlucocorticoid-induced osteoporosis (GIOP) is a common form of secondary osteoporosis caused by the protracted or a large dosage of glucocorticoids (GCs). Total flavonoids of Drynariae rhizoma (TFDR) have been widely used in treating postmenopausal osteoporosis (POP). However, their therap...

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Bibliographic Details
Main Authors:	Fangqing Zhang, Qiuyue Li, Jiashuo Wu, Haonan Ruan, Chuanrui Sun, Jia Zhu, Qinghui Song, Xu Wei, Yue Shi, Liguo Zhu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Endocrinology
Subjects:	total flavonoids of drynariae rhizome glucocorticoid-induced osteoporosis network pharmacology qualitative analysis PPAR γ
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2022.920931/full

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