Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck

Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck

Abundance and signaling of the epidermal growth factor receptor (EGFR) and programmed cell death protein ligand 1 (PD-L1) in head and neck squamous cell carcinoma (HNSCC) are not only genetically determined but are also subject to the traits of the tumor microenvironment, which has hitherto not been...

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Bibliographic Details
Main Authors: Sebastian Zahnreich, Senayit Gebrekidan, Gabriele Multhoff, Peter Vaupel, Heinz Schmidberger, Arnulf Mayer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
head and neck cancer
epidermal growth factor receptor
Ras-MAPK pathway
PI3K/AKT
PD-L1
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.623964/full

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