Small extracellular vesicles: Yields, functionalization and applications in diabetic wound management
Abstract Diabetic wounds have imposed a significant burden on both patients and society with prolonged healing processes hindered by dysfunctional skin repair cells. Small extracellular vesicles (sEVs), as the important media for intercellular communications, show promising therapeutic potential in...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-10-01
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| Series: | Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/INMD.20230019 |
| _version_ | 1797644471152672768 |
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| author | Xi Liu Qian Wei Zijie Sun Shengnan Cui Xizi Wan Ziqiang Chu Yikai Zhang Weicheng Zhong Lu Lu Lianxin Shi Xiaobing Fu Cuiping Zhang Shutao Wang |
| author_facet | Xi Liu Qian Wei Zijie Sun Shengnan Cui Xizi Wan Ziqiang Chu Yikai Zhang Weicheng Zhong Lu Lu Lianxin Shi Xiaobing Fu Cuiping Zhang Shutao Wang |
| author_sort | Xi Liu |
| collection | DOAJ |
| description | Abstract Diabetic wounds have imposed a significant burden on both patients and society with prolonged healing processes hindered by dysfunctional skin repair cells. Small extracellular vesicles (sEVs), as the important media for intercellular communications, show promising therapeutic potential in treating diabetic wounds by restoring cellular functions. However, low yields and limited bio‐function of sEVs greatly challenge their large‐scale clinical use. Here, we briefly overview the biogenesis and cellular uptake of sEVs, emphasize current advances in improving the yields of sEVs and optimizing the function of sEVs with engineering approaches, and summarize the applications of engineered sEVs in diabetic wound treatment. Furthermore, the undissolved issues during the clinical transformation of engineered sEVs are also discussed. This critical review aims to provide meaningful guidance for future applications of engineered sEVs in the management of diabetic wounds. |
| first_indexed | 2024-03-11T14:30:55Z |
| format | Article |
| id | doaj.art-321faed0c3504c2390ee2de3a6cd74a3 |
| institution | Directory Open Access Journal |
| issn | 2832-6245 |
| language | English |
| last_indexed | 2024-03-11T14:30:55Z |
| publishDate | 2023-10-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj.art-321faed0c3504c2390ee2de3a6cd74a32023-10-31T08:13:22ZengWiley-VCHInterdisciplinary Medicine2832-62452023-10-0114n/an/a10.1002/INMD.20230019Small extracellular vesicles: Yields, functionalization and applications in diabetic wound managementXi Liu0Qian Wei1Zijie Sun2Shengnan Cui3Xizi Wan4Ziqiang Chu5Yikai Zhang6Weicheng Zhong7Lu Lu8Lianxin Shi9Xiaobing Fu10Cuiping Zhang11Shutao Wang12Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College Beijing ChinaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College Beijing ChinaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College Beijing ChinaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College Beijing ChinaCAS Key Laboratory of Bio‐inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing ChinaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College Beijing ChinaCAS Key Laboratory of Bio‐inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing ChinaCollege of Graduate Tianjin Medical University Tianjin ChinaInstitute of NBC Defence PLA Army Beijing ChinaCAS Key Laboratory of Bio‐inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing ChinaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College Beijing ChinaResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College Beijing ChinaCAS Key Laboratory of Bio‐inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing ChinaAbstract Diabetic wounds have imposed a significant burden on both patients and society with prolonged healing processes hindered by dysfunctional skin repair cells. Small extracellular vesicles (sEVs), as the important media for intercellular communications, show promising therapeutic potential in treating diabetic wounds by restoring cellular functions. However, low yields and limited bio‐function of sEVs greatly challenge their large‐scale clinical use. Here, we briefly overview the biogenesis and cellular uptake of sEVs, emphasize current advances in improving the yields of sEVs and optimizing the function of sEVs with engineering approaches, and summarize the applications of engineered sEVs in diabetic wound treatment. Furthermore, the undissolved issues during the clinical transformation of engineered sEVs are also discussed. This critical review aims to provide meaningful guidance for future applications of engineered sEVs in the management of diabetic wounds.https://doi.org/10.1002/INMD.20230019diabetic wound healingengineeringfunctionalizationsmall extracellular vesiclesyields |
| spellingShingle | Xi Liu Qian Wei Zijie Sun Shengnan Cui Xizi Wan Ziqiang Chu Yikai Zhang Weicheng Zhong Lu Lu Lianxin Shi Xiaobing Fu Cuiping Zhang Shutao Wang Small extracellular vesicles: Yields, functionalization and applications in diabetic wound management Interdisciplinary Medicine diabetic wound healing engineering functionalization small extracellular vesicles yields |
| title | Small extracellular vesicles: Yields, functionalization and applications in diabetic wound management |
| title_full | Small extracellular vesicles: Yields, functionalization and applications in diabetic wound management |
| title_fullStr | Small extracellular vesicles: Yields, functionalization and applications in diabetic wound management |
| title_full_unstemmed | Small extracellular vesicles: Yields, functionalization and applications in diabetic wound management |
| title_short | Small extracellular vesicles: Yields, functionalization and applications in diabetic wound management |
| title_sort | small extracellular vesicles yields functionalization and applications in diabetic wound management |
| topic | diabetic wound healing engineering functionalization small extracellular vesicles yields |
| url | https://doi.org/10.1002/INMD.20230019 |
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