Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF<sup>V600E</sup> Protein

Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF<sup>V600E</sup> Protein

BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAF<sup>V600E</sup> mutated protein is targeted through the use of kinase inhibitors which are approved for the treatment of melanoma; however, their long-term efficacy is hampered by resistance mechanisms. The PROTA...

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Bibliographic Details
Main Authors: Elisabetta Marini, Marco Marino, Giulia Gionfriddo, Federica Maione, Marta Pandini, Daniele Oddo, Marta Giorgis, Barbara Rolando, Federica Blua, Simone Gastaldi, Serena Marchiò, Sandra Kovachka, Francesca Spyrakis, Eleonora Gianquinto, Federica Di Nicolantonio, Massimo Bertinaria
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
BRAF kinase
PROTACs
encorafenib
pomalidomide
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/27/23/8513

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