The Role of lncRNA Crosstalk in Leading Cancer Metastasis of Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of human malignancy. For decades, research into HNSCC invasion and metastasis has been dedicated to the study of protein-coding genes. Along with whole-genome and transcriptome sequencing development, long non-coding RNA (ln...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-10-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.561833/full |
| _version_ | 1818690404263919616 |
|---|---|
| author | Yu Wang Yu Wang Yu Wang Sinan Wang Sinan Wang Yu Ren Xuan Zhou Xuan Zhou Xuan Zhou |
| author_facet | Yu Wang Yu Wang Yu Wang Sinan Wang Sinan Wang Yu Ren Xuan Zhou Xuan Zhou Xuan Zhou |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of human malignancy. For decades, research into HNSCC invasion and metastasis has been dedicated to the study of protein-coding genes. Along with whole-genome and transcriptome sequencing development, long non-coding RNA (lncRNA) has attracted greater attention. Compelling evidence has proven the critical role of lncRNAs in the occurrence and development of HNSCC by means of epigenetic modifications, regulation of gene transcription, and post-transcription level. More importantly, crosstalk between lncRNAs and microRNAs was recently proven to regulate HNSCC metastasis through EMT modification. Based on these, this review summarizes the critical roles of lncRNAs in HNSCC metastasis and the crosstalk between lncRNAs and microRNAs as well as the detailed regulatory mechanism of the interaction. Thus, a deeper understanding of the lncRNA network in cancer metastasis is finally uncovered in order to provide a rationale and innovative concepts toward new therapeutic strategies for the highly metastatic HNSCC. |
| first_indexed | 2024-12-17T12:25:28Z |
| format | Article |
| id | doaj.art-3220ccb1bfdc445db865aacd889ffc22 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T12:25:28Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3220ccb1bfdc445db865aacd889ffc222022-12-21T21:48:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.561833561833The Role of lncRNA Crosstalk in Leading Cancer Metastasis of Head and Neck Squamous Cell CarcinomaYu Wang0Yu Wang1Yu Wang2Sinan Wang3Sinan Wang4Yu Ren5Xuan Zhou6Xuan Zhou7Xuan Zhou8Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, Tianjin, ChinaNational Clinical Research Center of Cancer, Tianjin, ChinaDepartment of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Gastroenterology and Hepatology Institute, Tianjin Medical University, Tianjin, ChinaTianjin Research Center of Basic Medical Science, Tianjin Medical University, Tianjin, ChinaDepartment of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaKey Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, Tianjin, ChinaNational Clinical Research Center of Cancer, Tianjin, ChinaHead and neck squamous cell carcinoma (HNSCC) is the sixth most common type of human malignancy. For decades, research into HNSCC invasion and metastasis has been dedicated to the study of protein-coding genes. Along with whole-genome and transcriptome sequencing development, long non-coding RNA (lncRNA) has attracted greater attention. Compelling evidence has proven the critical role of lncRNAs in the occurrence and development of HNSCC by means of epigenetic modifications, regulation of gene transcription, and post-transcription level. More importantly, crosstalk between lncRNAs and microRNAs was recently proven to regulate HNSCC metastasis through EMT modification. Based on these, this review summarizes the critical roles of lncRNAs in HNSCC metastasis and the crosstalk between lncRNAs and microRNAs as well as the detailed regulatory mechanism of the interaction. Thus, a deeper understanding of the lncRNA network in cancer metastasis is finally uncovered in order to provide a rationale and innovative concepts toward new therapeutic strategies for the highly metastatic HNSCC.https://www.frontiersin.org/article/10.3389/fonc.2020.561833/fullhead and neck squamous cell carcinomalong non-coding RNAmetastasisEMTinvasion |
| spellingShingle | Yu Wang Yu Wang Yu Wang Sinan Wang Sinan Wang Yu Ren Xuan Zhou Xuan Zhou Xuan Zhou The Role of lncRNA Crosstalk in Leading Cancer Metastasis of Head and Neck Squamous Cell Carcinoma Frontiers in Oncology head and neck squamous cell carcinoma long non-coding RNA metastasis EMT invasion |
| title | The Role of lncRNA Crosstalk in Leading Cancer Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_full | The Role of lncRNA Crosstalk in Leading Cancer Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_fullStr | The Role of lncRNA Crosstalk in Leading Cancer Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | The Role of lncRNA Crosstalk in Leading Cancer Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_short | The Role of lncRNA Crosstalk in Leading Cancer Metastasis of Head and Neck Squamous Cell Carcinoma |
| title_sort | role of lncrna crosstalk in leading cancer metastasis of head and neck squamous cell carcinoma |
| topic | head and neck squamous cell carcinoma long non-coding RNA metastasis EMT invasion |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.561833/full |
| work_keys_str_mv | AT yuwang theroleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT yuwang theroleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT yuwang theroleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT sinanwang theroleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT sinanwang theroleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT yuren theroleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT xuanzhou theroleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT xuanzhou theroleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT xuanzhou theroleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT yuwang roleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT yuwang roleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT yuwang roleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT sinanwang roleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT sinanwang roleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT yuren roleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT xuanzhou roleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT xuanzhou roleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma AT xuanzhou roleoflncrnacrosstalkinleadingcancermetastasisofheadandnecksquamouscellcarcinoma |