Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

Abstract Background Nuclear receptors NUR77 and NOR1 were identified as critical targets in acute myeloid leukemia (AML) therapy. Previously, we showed that Z-ligustilide (Z-LIG) selectively targeted AML by restoring NUR77 and NOR1. However, its downstream mechanisms are yet to be elucidated. Method...

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Bibliographic Details
Main Authors: Gen Liu, Zhi-gang Chen, Li-rong Yang, Yu-xia Rong, Qin Wang, Li Li, Qian-wei Lu, Ming-dong Jiang, Hong-yi Qi
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Chinese Medicine
Subjects:
Z-ligustilide
Acute myeloid leukemia
NUR77
NOR1
Mitochondrial dysfunction
Online Access:https://doi.org/10.1186/s13020-023-00808-7

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