Organometallic gold(I) and gold(III) complexes for lung cancer treatment
Metal compounds, especially gold complexes, have recently gained increasing attention as possible lung cancer therapeutics. Some gold complexes display not only excellent activity in cisplatin-sensitive lung cancer but also in cisplatin-resistant lung cancer, revealing promising prospects in the dev...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.979951/full |
| _version_ | 1811211340907282432 |
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| author | Juzheng Zhang Yanping Li Ronghao Fang Wei Wei Yong Wang Jiamin Jin Feng Yang Jian Chen |
| author_facet | Juzheng Zhang Yanping Li Ronghao Fang Wei Wei Yong Wang Jiamin Jin Feng Yang Jian Chen |
| author_sort | Juzheng Zhang |
| collection | DOAJ |
| description | Metal compounds, especially gold complexes, have recently gained increasing attention as possible lung cancer therapeutics. Some gold complexes display not only excellent activity in cisplatin-sensitive lung cancer but also in cisplatin-resistant lung cancer, revealing promising prospects in the development of novel treatments for lung cancer. This review summarizes examples of anticancer gold(I) and gold (III) complexes for lung cancer treatment, including mechanisms of action and approaches adopted to improve their efficiency. Several excellent examples of gold complexes against lung cancer are highlighted. |
| first_indexed | 2024-04-12T05:11:17Z |
| format | Article |
| id | doaj.art-322324c4ffdd40fe9fd35ee1c5ea9495 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T05:11:17Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-322324c4ffdd40fe9fd35ee1c5ea94952022-12-22T03:46:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.979951979951Organometallic gold(I) and gold(III) complexes for lung cancer treatmentJuzheng Zhang0Yanping Li1Ronghao Fang2Wei Wei3Yong Wang4Jiamin Jin5Feng Yang6Jian Chen7Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, ChinaSchool of Public Health, Guilin Medical University, Guilin, ChinaGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, ChinaGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, ChinaGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, ChinaGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, ChinaGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, ChinaMetal compounds, especially gold complexes, have recently gained increasing attention as possible lung cancer therapeutics. Some gold complexes display not only excellent activity in cisplatin-sensitive lung cancer but also in cisplatin-resistant lung cancer, revealing promising prospects in the development of novel treatments for lung cancer. This review summarizes examples of anticancer gold(I) and gold (III) complexes for lung cancer treatment, including mechanisms of action and approaches adopted to improve their efficiency. Several excellent examples of gold complexes against lung cancer are highlighted.https://www.frontiersin.org/articles/10.3389/fphar.2022.979951/fullGold(I) complexesgold(III) complexesanticancerlung cancerA549 |
| spellingShingle | Juzheng Zhang Yanping Li Ronghao Fang Wei Wei Yong Wang Jiamin Jin Feng Yang Jian Chen Organometallic gold(I) and gold(III) complexes for lung cancer treatment Frontiers in Pharmacology Gold(I) complexes gold(III) complexes anticancer lung cancer A549 |
| title | Organometallic gold(I) and gold(III) complexes for lung cancer treatment |
| title_full | Organometallic gold(I) and gold(III) complexes for lung cancer treatment |
| title_fullStr | Organometallic gold(I) and gold(III) complexes for lung cancer treatment |
| title_full_unstemmed | Organometallic gold(I) and gold(III) complexes for lung cancer treatment |
| title_short | Organometallic gold(I) and gold(III) complexes for lung cancer treatment |
| title_sort | organometallic gold i and gold iii complexes for lung cancer treatment |
| topic | Gold(I) complexes gold(III) complexes anticancer lung cancer A549 |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.979951/full |
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