Meningoencephalitis secondary to rhinitis caused by Pythium insidiosum in sheep
ABSTRACT: A case of meningoencephalitis caused by Pythium insidiosum secondary to rhinitis is reported in a three-year-old crossbred sheep from a herd of 15 animals, raised extensively and with free access to a weir. The animal presented mild dyspnea, blindness, mydriasis, opisthotonos, nystagmus, i...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Santa Maria
2022-08-01
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| Series: | Ciência Rural |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782023000600551&tlng=en |
| _version_ | 1818494811921973248 |
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| author | Millena de Oliveira Firmino Ialys Macêdo Leite Davi Emanuel Ribeiro de Sousa Lisanka Ângelo Maia Sara Vilar Dantas Simões Glaucia Denise Kommers Glauco José Nogueira de Galiza Antônio Flávio Medeiros Dantas |
| author_facet | Millena de Oliveira Firmino Ialys Macêdo Leite Davi Emanuel Ribeiro de Sousa Lisanka Ângelo Maia Sara Vilar Dantas Simões Glaucia Denise Kommers Glauco José Nogueira de Galiza Antônio Flávio Medeiros Dantas |
| author_sort | Millena de Oliveira Firmino |
| collection | DOAJ |
| description | ABSTRACT: A case of meningoencephalitis caused by Pythium insidiosum secondary to rhinitis is reported in a three-year-old crossbred sheep from a herd of 15 animals, raised extensively and with free access to a weir. The animal presented mild dyspnea, blindness, mydriasis, opisthotonos, nystagmus, incoordination, decreased mandibular tone, and spasticity of the pelvic limbs. Macroscopic examination of the nasal cavity showed a blackish-red, irregular, friable mass that bilaterally compromised the nasal septum and the rostral portion of the nasal turbinates. In the brain, there was diffuse thickening of the leptomeninges of the cerebellum and ventral portion of the brainstem characterized by yellowish, granular material associated with vessel hyperemia. On the floor of the fourth ventricle, there was deposition of yellowish, irregular, slightly granular material that protruded towards the obex and displaced the cerebellum dorsolaterally. Microscopically, there were pyogranulomatous, eosinophilic, necrotizing rhinitis and fibrinosuppurative, eosinophilic, necrotizing meningoencephalitis, both associated with thrombosis, vasculitis, and intralesional hyphae. The hyphae were impregnated with silver and presented thin, parallel walls, rarely septate and branched. At immunohistochemistry, the hyphae were immunostained with polyclonal anti-P. insidiosum antibody in fragments of the cerebellum and nasal cavity. The findings showed that P. insidiosum rhinitis can secondarily affect the nervous system of sheep, causing nonspecific neurological clinical signs. |
| first_indexed | 2024-12-10T18:11:46Z |
| format | Article |
| id | doaj.art-32240e32433140599082d79aa653df64 |
| institution | Directory Open Access Journal |
| issn | 1678-4596 |
| language | English |
| last_indexed | 2024-12-10T18:11:46Z |
| publishDate | 2022-08-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj.art-32240e32433140599082d79aa653df642022-12-22T01:38:25ZengUniversidade Federal de Santa MariaCiência Rural1678-45962022-08-0153610.1590/0103-8478cr20220038Meningoencephalitis secondary to rhinitis caused by Pythium insidiosum in sheepMillena de Oliveira Firminohttps://orcid.org/0000-0002-8283-6666Ialys Macêdo Leitehttps://orcid.org/0000-0003-4524-1265Davi Emanuel Ribeiro de Sousahttps://orcid.org/0000-0003-1237-0693Lisanka Ângelo Maiahttps://orcid.org/0000-0002-2471-5700Sara Vilar Dantas Simõeshttps://orcid.org/0000-0003-3692-9199Glaucia Denise Kommershttps://orcid.org/0000-0002-2255-3015Glauco José Nogueira de Galizahttps://orcid.org/0000-0002-0551-1964Antônio Flávio Medeiros Dantashttps://orcid.org/0000-0002-6123-2273ABSTRACT: A case of meningoencephalitis caused by Pythium insidiosum secondary to rhinitis is reported in a three-year-old crossbred sheep from a herd of 15 animals, raised extensively and with free access to a weir. The animal presented mild dyspnea, blindness, mydriasis, opisthotonos, nystagmus, incoordination, decreased mandibular tone, and spasticity of the pelvic limbs. Macroscopic examination of the nasal cavity showed a blackish-red, irregular, friable mass that bilaterally compromised the nasal septum and the rostral portion of the nasal turbinates. In the brain, there was diffuse thickening of the leptomeninges of the cerebellum and ventral portion of the brainstem characterized by yellowish, granular material associated with vessel hyperemia. On the floor of the fourth ventricle, there was deposition of yellowish, irregular, slightly granular material that protruded towards the obex and displaced the cerebellum dorsolaterally. Microscopically, there were pyogranulomatous, eosinophilic, necrotizing rhinitis and fibrinosuppurative, eosinophilic, necrotizing meningoencephalitis, both associated with thrombosis, vasculitis, and intralesional hyphae. The hyphae were impregnated with silver and presented thin, parallel walls, rarely septate and branched. At immunohistochemistry, the hyphae were immunostained with polyclonal anti-P. insidiosum antibody in fragments of the cerebellum and nasal cavity. The findings showed that P. insidiosum rhinitis can secondarily affect the nervous system of sheep, causing nonspecific neurological clinical signs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782023000600551&tlng=enhematogenic disseminationvasculitispythiosisPythium insidiosum |
| spellingShingle | Millena de Oliveira Firmino Ialys Macêdo Leite Davi Emanuel Ribeiro de Sousa Lisanka Ângelo Maia Sara Vilar Dantas Simões Glaucia Denise Kommers Glauco José Nogueira de Galiza Antônio Flávio Medeiros Dantas Meningoencephalitis secondary to rhinitis caused by Pythium insidiosum in sheep Ciência Rural hematogenic dissemination vasculitis pythiosis Pythium insidiosum |
| title | Meningoencephalitis secondary to rhinitis caused by Pythium insidiosum in sheep |
| title_full | Meningoencephalitis secondary to rhinitis caused by Pythium insidiosum in sheep |
| title_fullStr | Meningoencephalitis secondary to rhinitis caused by Pythium insidiosum in sheep |
| title_full_unstemmed | Meningoencephalitis secondary to rhinitis caused by Pythium insidiosum in sheep |
| title_short | Meningoencephalitis secondary to rhinitis caused by Pythium insidiosum in sheep |
| title_sort | meningoencephalitis secondary to rhinitis caused by pythium insidiosum in sheep |
| topic | hematogenic dissemination vasculitis pythiosis Pythium insidiosum |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782023000600551&tlng=en |
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