Insulin overdose complicated by treatment‐induced acute hepatic steatosis in a nondiabetic patient
Background There are few reports of dextrose‐associated hepatic steatosis during insulin overdose treatment. Reports in nondiabetic patients are extremely rare. There is inadequate knowledge about the clinical course and treatment. Case Presentation A 37‐year‐old previously healthy, nondiabetic man...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Acute Medicine & Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ams2.772 |
| _version_ | 1797976126867374080 |
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| author | Noriyuki Okamoto Shinsuke Onishi Toshiyuki Onodera Toshihiro Tawara Hiroyuki Okamoto Takafumi Shimizu Akiko Oshiro Yuka Morishita Satoshi Nara |
| author_facet | Noriyuki Okamoto Shinsuke Onishi Toshiyuki Onodera Toshihiro Tawara Hiroyuki Okamoto Takafumi Shimizu Akiko Oshiro Yuka Morishita Satoshi Nara |
| author_sort | Noriyuki Okamoto |
| collection | DOAJ |
| description | Background There are few reports of dextrose‐associated hepatic steatosis during insulin overdose treatment. Reports in nondiabetic patients are extremely rare. There is inadequate knowledge about the clinical course and treatment. Case Presentation A 37‐year‐old previously healthy, nondiabetic man self‐administered 5,925 IU of insulin. On admission, his liver function tests were normal. However, following continued dextrose treatment, they increased, and he was diagnosed with hepatic steatosis. The liver function tests improved with decreasing dextrose dosage, and he was asymptomatic on discharge. Conclusion Acute hepatic steatosis may occur in nondiabetic and diabetic patients during treatment requiring large doses of dextrose infusion, such as for an insulin overdose. In addition, the degree of liver damage might also be related to the dextrose dose. Therefore, careful glycemic control and minimization of the dextrose dosage are recommended for diabetic and nondiabetic patients. |
| first_indexed | 2024-04-11T04:46:24Z |
| format | Article |
| id | doaj.art-3229429a0d704130b5eee76d732087f0 |
| institution | Directory Open Access Journal |
| issn | 2052-8817 |
| language | English |
| last_indexed | 2024-04-11T04:46:24Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Acute Medicine & Surgery |
| spelling | doaj.art-3229429a0d704130b5eee76d732087f02022-12-27T12:22:50ZengWileyAcute Medicine & Surgery2052-88172022-01-0191n/an/a10.1002/ams2.772Insulin overdose complicated by treatment‐induced acute hepatic steatosis in a nondiabetic patientNoriyuki Okamoto0Shinsuke Onishi1Toshiyuki Onodera2Toshihiro Tawara3Hiroyuki Okamoto4Takafumi Shimizu5Akiko Oshiro6Yuka Morishita7Satoshi Nara8Emergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido JapanEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido JapanEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido JapanEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido JapanEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido JapanEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido JapanEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido JapanEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido JapanEmergency and Critical Care Medical Center Teine Keijinkai Hospital Sapporo Hokkaido JapanBackground There are few reports of dextrose‐associated hepatic steatosis during insulin overdose treatment. Reports in nondiabetic patients are extremely rare. There is inadequate knowledge about the clinical course and treatment. Case Presentation A 37‐year‐old previously healthy, nondiabetic man self‐administered 5,925 IU of insulin. On admission, his liver function tests were normal. However, following continued dextrose treatment, they increased, and he was diagnosed with hepatic steatosis. The liver function tests improved with decreasing dextrose dosage, and he was asymptomatic on discharge. Conclusion Acute hepatic steatosis may occur in nondiabetic and diabetic patients during treatment requiring large doses of dextrose infusion, such as for an insulin overdose. In addition, the degree of liver damage might also be related to the dextrose dose. Therefore, careful glycemic control and minimization of the dextrose dosage are recommended for diabetic and nondiabetic patients.https://doi.org/10.1002/ams2.772Dextrosedrug overdosehepatic steatosisinsulinliver injury |
| spellingShingle | Noriyuki Okamoto Shinsuke Onishi Toshiyuki Onodera Toshihiro Tawara Hiroyuki Okamoto Takafumi Shimizu Akiko Oshiro Yuka Morishita Satoshi Nara Insulin overdose complicated by treatment‐induced acute hepatic steatosis in a nondiabetic patient Acute Medicine & Surgery Dextrose drug overdose hepatic steatosis insulin liver injury |
| title | Insulin overdose complicated by treatment‐induced acute hepatic steatosis in a nondiabetic patient |
| title_full | Insulin overdose complicated by treatment‐induced acute hepatic steatosis in a nondiabetic patient |
| title_fullStr | Insulin overdose complicated by treatment‐induced acute hepatic steatosis in a nondiabetic patient |
| title_full_unstemmed | Insulin overdose complicated by treatment‐induced acute hepatic steatosis in a nondiabetic patient |
| title_short | Insulin overdose complicated by treatment‐induced acute hepatic steatosis in a nondiabetic patient |
| title_sort | insulin overdose complicated by treatment induced acute hepatic steatosis in a nondiabetic patient |
| topic | Dextrose drug overdose hepatic steatosis insulin liver injury |
| url | https://doi.org/10.1002/ams2.772 |
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