The Function of Autophagy as a Regulator of Melanin Homeostasis
Melanosomes are melanocyte-specific organelles that protect cells from ultraviolet (UV)-induced deoxyribonucleic acid damage through the production and accumulation of melanin and are transferred from melanocytes to keratinocytes. The relatively well-known process by which melanin is synthesized fro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/13/2085 |
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| author | Ki Won Lee Minju Kim Si Hyeon Lee Kwang Dong Kim |
| author_facet | Ki Won Lee Minju Kim Si Hyeon Lee Kwang Dong Kim |
| author_sort | Ki Won Lee |
| collection | DOAJ |
| description | Melanosomes are melanocyte-specific organelles that protect cells from ultraviolet (UV)-induced deoxyribonucleic acid damage through the production and accumulation of melanin and are transferred from melanocytes to keratinocytes. The relatively well-known process by which melanin is synthesized from melanocytes is known as melanogenesis. The relationship between melanogenesis and autophagy is attracting the attention of researchers because proteins associated with autophagy, such as WD repeat domain phosphoinositide-interacting protein 1, microtubule-associated protein 1 light chain 3, autophagy-related (ATG)7, ATG4, beclin-1, and UV-radiation resistance-associated gene, contribute to the melanogenesis signaling pathway. Additionally, there are reports that some compounds used as whitening cosmetics materials induce skin depigmentation through autophagy. Thus, the possibility that autophagy is involved in the removal of melanin has been suggested. To date, however, there is a lack of data on melanosome autophagy and its underlying mechanism. This review highlights the importance of autophagy in melanin homeostasis by providing an overview of melanogenesis, autophagy, the autophagy machinery involved in melanogenesis, and natural compounds that induce autophagy-mediated depigmentation. |
| first_indexed | 2024-03-09T22:01:20Z |
| format | Article |
| id | doaj.art-322a483df86143bb9fd9faf16207aab6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T22:01:20Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-322a483df86143bb9fd9faf16207aab62023-11-23T19:49:14ZengMDPI AGCells2073-44092022-06-011113208510.3390/cells11132085The Function of Autophagy as a Regulator of Melanin HomeostasisKi Won Lee0Minju Kim1Si Hyeon Lee2Kwang Dong Kim3PMBBRC, Gyeongsang National University, Jinju 52828, KoreaDivision of Applied Life Science, Gyeongsang National University, Jinju 52828, KoreaDivision of Applied Life Science, Gyeongsang National University, Jinju 52828, KoreaPMBBRC, Gyeongsang National University, Jinju 52828, KoreaMelanosomes are melanocyte-specific organelles that protect cells from ultraviolet (UV)-induced deoxyribonucleic acid damage through the production and accumulation of melanin and are transferred from melanocytes to keratinocytes. The relatively well-known process by which melanin is synthesized from melanocytes is known as melanogenesis. The relationship between melanogenesis and autophagy is attracting the attention of researchers because proteins associated with autophagy, such as WD repeat domain phosphoinositide-interacting protein 1, microtubule-associated protein 1 light chain 3, autophagy-related (ATG)7, ATG4, beclin-1, and UV-radiation resistance-associated gene, contribute to the melanogenesis signaling pathway. Additionally, there are reports that some compounds used as whitening cosmetics materials induce skin depigmentation through autophagy. Thus, the possibility that autophagy is involved in the removal of melanin has been suggested. To date, however, there is a lack of data on melanosome autophagy and its underlying mechanism. This review highlights the importance of autophagy in melanin homeostasis by providing an overview of melanogenesis, autophagy, the autophagy machinery involved in melanogenesis, and natural compounds that induce autophagy-mediated depigmentation.https://www.mdpi.com/2073-4409/11/13/2085autophagymelanogenesismelanin |
| spellingShingle | Ki Won Lee Minju Kim Si Hyeon Lee Kwang Dong Kim The Function of Autophagy as a Regulator of Melanin Homeostasis Cells autophagy melanogenesis melanin |
| title | The Function of Autophagy as a Regulator of Melanin Homeostasis |
| title_full | The Function of Autophagy as a Regulator of Melanin Homeostasis |
| title_fullStr | The Function of Autophagy as a Regulator of Melanin Homeostasis |
| title_full_unstemmed | The Function of Autophagy as a Regulator of Melanin Homeostasis |
| title_short | The Function of Autophagy as a Regulator of Melanin Homeostasis |
| title_sort | function of autophagy as a regulator of melanin homeostasis |
| topic | autophagy melanogenesis melanin |
| url | https://www.mdpi.com/2073-4409/11/13/2085 |
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