Co(II), Ni(II), Cu(II), and Zn(II) complexes derived from 4-[{3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene}-amino]-3-mercapto-6-methyl-5-oxo-1,2,4-triazine
A new series of Co(II), Ni(II), Cu(II) and Zn(II) complexes were prepared with bidentate ligand derived by condensation of 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine with 3-(p-bromophenyl)-1-phenyl-1H-pyrazolecarboxaldehyde. The Schiff base and its metal complexes were characterized on the bas...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2016-03-01
|
| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2314853516000111 |
| _version_ | 1818492212873265152 |
|---|---|
| author | Kiran Singh Ritu Thakur Vikas Kumar |
| author_facet | Kiran Singh Ritu Thakur Vikas Kumar |
| author_sort | Kiran Singh |
| collection | DOAJ |
| description | A new series of Co(II), Ni(II), Cu(II) and Zn(II) complexes were prepared with bidentate ligand derived by condensation of 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine with 3-(p-bromophenyl)-1-phenyl-1H-pyrazolecarboxaldehyde. The Schiff base and its metal complexes were characterized on the basis of various spectroscopic investigation like IR, NMR, fluorescence and thermal analyses. The coordinated water molecules were confirmed by IR and thermal data, while the geometry of the complexes was confirmed by electronic spectra, magnetic moment measurements and ESR analysis. Cyclic voltammetry shows the redox behavior of copper complexes. All the complexes were colored, stable in air and non-electrolytic in nature. Schiff base and its metal complexes were screened for in vitro antimicrobial activity and it was observed that metal complexes show enhanced biological activity as compared to ligand or metal salts. In addition, Zn(II) complexes show enhanced biological activity against most of the microbial strains as compared to ligand and other metal complexes. |
| first_indexed | 2024-12-10T17:40:15Z |
| format | Article |
| id | doaj.art-322aecc0a65241d2a4939321e5dabb74 |
| institution | Directory Open Access Journal |
| issn | 2314-8535 |
| language | English |
| last_indexed | 2024-12-10T17:40:15Z |
| publishDate | 2016-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj.art-322aecc0a65241d2a4939321e5dabb742022-12-22T01:39:24ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85352016-03-0151213010.1016/j.bjbas.2016.02.001Co(II), Ni(II), Cu(II), and Zn(II) complexes derived from 4-[{3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene}-amino]-3-mercapto-6-methyl-5-oxo-1,2,4-triazineKiran Singh0Ritu Thakur1Vikas Kumar2Department of Chemistry, Kurukshetra University, Kurukshetra 136119, IndiaDepartment of Chemistry, Kurukshetra University, Kurukshetra 136119, IndiaDepartment of Microbiology, Kurukshetra University, Kurukshetra 136119, IndiaA new series of Co(II), Ni(II), Cu(II) and Zn(II) complexes were prepared with bidentate ligand derived by condensation of 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine with 3-(p-bromophenyl)-1-phenyl-1H-pyrazolecarboxaldehyde. The Schiff base and its metal complexes were characterized on the basis of various spectroscopic investigation like IR, NMR, fluorescence and thermal analyses. The coordinated water molecules were confirmed by IR and thermal data, while the geometry of the complexes was confirmed by electronic spectra, magnetic moment measurements and ESR analysis. Cyclic voltammetry shows the redox behavior of copper complexes. All the complexes were colored, stable in air and non-electrolytic in nature. Schiff base and its metal complexes were screened for in vitro antimicrobial activity and it was observed that metal complexes show enhanced biological activity as compared to ligand or metal salts. In addition, Zn(II) complexes show enhanced biological activity against most of the microbial strains as compared to ligand and other metal complexes.http://www.sciencedirect.com/science/article/pii/S2314853516000111Schiff baseAntimicrobial activityPyrazole moiety1,2,4-triazineMetal complexes |
| spellingShingle | Kiran Singh Ritu Thakur Vikas Kumar Co(II), Ni(II), Cu(II), and Zn(II) complexes derived from 4-[{3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene}-amino]-3-mercapto-6-methyl-5-oxo-1,2,4-triazine Beni-Suef University Journal of Basic and Applied Sciences Schiff base Antimicrobial activity Pyrazole moiety 1,2,4-triazine Metal complexes |
| title | Co(II), Ni(II), Cu(II), and Zn(II) complexes derived from 4-[{3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene}-amino]-3-mercapto-6-methyl-5-oxo-1,2,4-triazine |
| title_full | Co(II), Ni(II), Cu(II), and Zn(II) complexes derived from 4-[{3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene}-amino]-3-mercapto-6-methyl-5-oxo-1,2,4-triazine |
| title_fullStr | Co(II), Ni(II), Cu(II), and Zn(II) complexes derived from 4-[{3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene}-amino]-3-mercapto-6-methyl-5-oxo-1,2,4-triazine |
| title_full_unstemmed | Co(II), Ni(II), Cu(II), and Zn(II) complexes derived from 4-[{3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene}-amino]-3-mercapto-6-methyl-5-oxo-1,2,4-triazine |
| title_short | Co(II), Ni(II), Cu(II), and Zn(II) complexes derived from 4-[{3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-ylmethylene}-amino]-3-mercapto-6-methyl-5-oxo-1,2,4-triazine |
| title_sort | co ii ni ii cu ii and zn ii complexes derived from 4 3 4 bromophenyl 1 phenyl 1h pyrazol 4 ylmethylene amino 3 mercapto 6 methyl 5 oxo 1 2 4 triazine |
| topic | Schiff base Antimicrobial activity Pyrazole moiety 1,2,4-triazine Metal complexes |
| url | http://www.sciencedirect.com/science/article/pii/S2314853516000111 |
| work_keys_str_mv | AT kiransingh coiiniiicuiiandzniicomplexesderivedfrom434bromophenyl1phenyl1hpyrazol4ylmethyleneamino3mercapto6methyl5oxo124triazine AT rituthakur coiiniiicuiiandzniicomplexesderivedfrom434bromophenyl1phenyl1hpyrazol4ylmethyleneamino3mercapto6methyl5oxo124triazine AT vikaskumar coiiniiicuiiandzniicomplexesderivedfrom434bromophenyl1phenyl1hpyrazol4ylmethyleneamino3mercapto6methyl5oxo124triazine |