Translation and functional roles of circular RNAs in human cancer
Abstract Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed loops through backsplicing. Recent methodologies have enabled in-depth characterization of circRNAs for identification and potential functions. CircRNAs play important roles in various biological functio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-02-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-020-1135-7 |
| _version_ | 1818609761908686848 |
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| author | Ming Lei Guantao Zheng Qianqian Ning Junnian Zheng Dong Dong |
| author_facet | Ming Lei Guantao Zheng Qianqian Ning Junnian Zheng Dong Dong |
| author_sort | Ming Lei |
| collection | DOAJ |
| description | Abstract Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed loops through backsplicing. Recent methodologies have enabled in-depth characterization of circRNAs for identification and potential functions. CircRNAs play important roles in various biological functions as microRNA sponges, transcriptional regulators and combining with RNA binding proteins. Recent studies indicated that some cytoplasmic circRNAs can be effectively translated into detectable peptides, which enlightened us on the importance of circRNAs in cellular physiology function. Internal Ribosome Entry site (IRES)- and N6-methyladenosines (m6A)-mediated cap-independent translation initiation have been suggested to be potential mechanism for circRNA translation. To date, several translated circRNAs have been uncovered to play pivotal roles in human cancers. In this review, we introduced the properties and functions of circRNAs, and characterized the possible mechanism of translation initiation and complexity of the translation ability of circRNAs. We summarized the emerging functions of circRNA-encoded proteins in human cancer. The works on circRNA translation will open a hidden human proteome, and enhance us to understand the importance of circRNAs in human cancer, which has been poorly explored so far. |
| first_indexed | 2024-12-16T15:03:41Z |
| format | Article |
| id | doaj.art-322d0fd136fa44d3959be229786488a9 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-16T15:03:41Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-322d0fd136fa44d3959be229786488a92022-12-21T22:27:12ZengBMCMolecular Cancer1476-45982020-02-011911910.1186/s12943-020-1135-7Translation and functional roles of circular RNAs in human cancerMing Lei0Guantao Zheng1Qianqian Ning2Junnian Zheng3Dong Dong4Cancer Institute, Xuzhou Medical UniversityCancer Institute, Xuzhou Medical UniversityCancer Institute, Xuzhou Medical UniversityCancer Institute, Xuzhou Medical UniversityCancer Institute, Xuzhou Medical UniversityAbstract Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed loops through backsplicing. Recent methodologies have enabled in-depth characterization of circRNAs for identification and potential functions. CircRNAs play important roles in various biological functions as microRNA sponges, transcriptional regulators and combining with RNA binding proteins. Recent studies indicated that some cytoplasmic circRNAs can be effectively translated into detectable peptides, which enlightened us on the importance of circRNAs in cellular physiology function. Internal Ribosome Entry site (IRES)- and N6-methyladenosines (m6A)-mediated cap-independent translation initiation have been suggested to be potential mechanism for circRNA translation. To date, several translated circRNAs have been uncovered to play pivotal roles in human cancers. In this review, we introduced the properties and functions of circRNAs, and characterized the possible mechanism of translation initiation and complexity of the translation ability of circRNAs. We summarized the emerging functions of circRNA-encoded proteins in human cancer. The works on circRNA translation will open a hidden human proteome, and enhance us to understand the importance of circRNAs in human cancer, which has been poorly explored so far.https://doi.org/10.1186/s12943-020-1135-7Circular RNATranslationFunctionCancerBiomarker |
| spellingShingle | Ming Lei Guantao Zheng Qianqian Ning Junnian Zheng Dong Dong Translation and functional roles of circular RNAs in human cancer Molecular Cancer Circular RNA Translation Function Cancer Biomarker |
| title | Translation and functional roles of circular RNAs in human cancer |
| title_full | Translation and functional roles of circular RNAs in human cancer |
| title_fullStr | Translation and functional roles of circular RNAs in human cancer |
| title_full_unstemmed | Translation and functional roles of circular RNAs in human cancer |
| title_short | Translation and functional roles of circular RNAs in human cancer |
| title_sort | translation and functional roles of circular rnas in human cancer |
| topic | Circular RNA Translation Function Cancer Biomarker |
| url | https://doi.org/10.1186/s12943-020-1135-7 |
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