DNA methylation patterns in CD4+ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis

DNA methylation patterns in CD4+ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis

BackgroundPsoriasis is an autoimmune/inflammatory disorder primarily affecting the skin. Chronic joint inflammation triggers the diagnosis of psoriatic arthritis (PsA) in approximately one-third of psoriasis patients. Although joint disease typically follows the onset of skin psoriasis, in around 15...

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Bibliographic Details
Main Authors: Valentina Natoli, Amandine Charras, Sigrun R. Hofmann, Sarah Northey, Susanne Russ, Felix Schulze, Liza McCann, Susanne Abraham, Christian M. Hedrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
psoriasis
psoriatic arthritis
CD4+ T-cell
epigenetics
methylation
interferon
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1245876/full

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