Regulation of cell proliferation and migration in glioblastoma: New therapeutic approach
Glioblastoma is the aggressive brain cancer with the poor survival rate. A microRNA, miR-451, and its downstream molecules, CAB39/LKB1/STRAD/AMPK, are known to play a critical role in regulating a biochemical balance between rapid proliferation and invasion in the presence of metabolic stress in mic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00053/full |
| _version_ | 1818984084016201728 |
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| author | Yangjin eKim |
| author_facet | Yangjin eKim |
| author_sort | Yangjin eKim |
| collection | DOAJ |
| description | Glioblastoma is the aggressive brain cancer with the poor survival rate. A microRNA, miR-451, and its downstream molecules, CAB39/LKB1/STRAD/AMPK, are known to play a critical role in regulating a biochemical balance between rapid proliferation and invasion in the presence of metabolic stress in microenvironment. We develop a novel multi-scale mathematical model where cell migration and proliferation are controlled through a core intracellular control system (miR-451-AMPK complex) in response to glucose availability and physical constraints in the microenvironment. Tumor cells are modeled individually and proliferation and migration of those cells are regulated by the intracellular dynamics and reaction-di□usion equations of concentrations of glucose, chemoattractant, extracellular matrix, and MMPs. The model predicts that invasion patterns and rapid growth of tumor cells after conventional surgery depend onbiophysical properties of cells, dynamics of the core control system, and microenvironment as well as glucose injection methods. We developed a new type of therapeutic approaches: effective injection of chemoattractant for bring invasive cells back to the surgical site after initial surgery, followed by glucose injection at the same location. The model suggests that a good combination of chemoattractant and glucose injection at appropriate time frames may lead to an effective therapeutic strategy of eradicating tumor cells. |
| first_indexed | 2024-12-20T18:13:22Z |
| format | Article |
| id | doaj.art-322df9e0bc47438c914d5578d81bb847 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T18:13:22Z |
| publishDate | 2013-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-322df9e0bc47438c914d5578d81bb8472022-12-21T19:30:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2013-03-01310.3389/fonc.2013.0005342350Regulation of cell proliferation and migration in glioblastoma: New therapeutic approachYangjin eKim0University of MichiganGlioblastoma is the aggressive brain cancer with the poor survival rate. A microRNA, miR-451, and its downstream molecules, CAB39/LKB1/STRAD/AMPK, are known to play a critical role in regulating a biochemical balance between rapid proliferation and invasion in the presence of metabolic stress in microenvironment. We develop a novel multi-scale mathematical model where cell migration and proliferation are controlled through a core intracellular control system (miR-451-AMPK complex) in response to glucose availability and physical constraints in the microenvironment. Tumor cells are modeled individually and proliferation and migration of those cells are regulated by the intracellular dynamics and reaction-di□usion equations of concentrations of glucose, chemoattractant, extracellular matrix, and MMPs. The model predicts that invasion patterns and rapid growth of tumor cells after conventional surgery depend onbiophysical properties of cells, dynamics of the core control system, and microenvironment as well as glucose injection methods. We developed a new type of therapeutic approaches: effective injection of chemoattractant for bring invasive cells back to the surgical site after initial surgery, followed by glucose injection at the same location. The model suggests that a good combination of chemoattractant and glucose injection at appropriate time frames may lead to an effective therapeutic strategy of eradicating tumor cells.http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00053/fullAMPKGlioblasomacell migration and proliferationmiR-451cancer invasion and therapy |
| spellingShingle | Yangjin eKim Regulation of cell proliferation and migration in glioblastoma: New therapeutic approach Frontiers in Oncology AMPK Glioblasoma cell migration and proliferation miR-451 cancer invasion and therapy |
| title | Regulation of cell proliferation and migration in glioblastoma: New therapeutic approach |
| title_full | Regulation of cell proliferation and migration in glioblastoma: New therapeutic approach |
| title_fullStr | Regulation of cell proliferation and migration in glioblastoma: New therapeutic approach |
| title_full_unstemmed | Regulation of cell proliferation and migration in glioblastoma: New therapeutic approach |
| title_short | Regulation of cell proliferation and migration in glioblastoma: New therapeutic approach |
| title_sort | regulation of cell proliferation and migration in glioblastoma new therapeutic approach |
| topic | AMPK Glioblasoma cell migration and proliferation miR-451 cancer invasion and therapy |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00053/full |
| work_keys_str_mv | AT yangjinekim regulationofcellproliferationandmigrationinglioblastomanewtherapeuticapproach |