Ischemic Stroke and Acute Coronary Syndrome (ACS) in COVID-19 patients: Mechanisms and Role of Coagulopathy
COVID-19 has a devastating impact on patients not only due to the severity of pulmonary disease but also the multitude of other manifestations. We discuss here myocardial ischemia and stroke, associated with COVID-19, from a hyper coagulation perspective. Original studies, case reports, and system...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Liaquat National Hospital and Medical College
2023-08-01
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| Series: | Liaquat National Journal of Primary Care |
| Subjects: | |
| Online Access: | https://journals.lnh.edu.pk/lnjpc/pdf/45fd7d62-2b27-4721-99fe-c3e1e3cca32c.pdf |
| _version_ | 1827944138876649472 |
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| author | Syed Mujtaba Azhar Bokhari Muhammad Irfan Kaleem |
| author_facet | Syed Mujtaba Azhar Bokhari Muhammad Irfan Kaleem |
| author_sort | Syed Mujtaba Azhar Bokhari |
| collection | DOAJ |
| description | COVID-19 has a devastating impact on patients not only due to the severity of pulmonary disease but also the multitude of other
manifestations. We discuss here myocardial ischemia and stroke, associated with COVID-19, from a hyper coagulation perspective.
Original studies, case reports, and systematic reviews from different databases were studied for this review article. Elevated
inflammatory markers (e.g. ferritin, C reactive protein, interleukins, antiphospholipid antibodies) together with elevated D-dimer
levels point to an inflammatory source of activation of the coagulation cascade. Furthermore, the features of macro and micro
thrombi, because of dysregulated coagulation, point to local thrombosis as well as distant thrombo-embolism. Inflammation cascade
and changes in coagulation markers leading to coagulopathy in COVID-19 patients emphasize the need to develop investigation
techniques that can independently guide therapy. |
| first_indexed | 2024-03-13T10:26:36Z |
| format | Article |
| id | doaj.art-322e414428684d518cd54218f8fb3ff5 |
| institution | Directory Open Access Journal |
| issn | 2707-3521 2708-9134 |
| language | English |
| last_indexed | 2024-03-13T10:26:36Z |
| publishDate | 2023-08-01 |
| publisher | Liaquat National Hospital and Medical College |
| record_format | Article |
| series | Liaquat National Journal of Primary Care |
| spelling | doaj.art-322e414428684d518cd54218f8fb3ff52023-05-19T07:43:05ZengLiaquat National Hospital and Medical CollegeLiaquat National Journal of Primary Care2707-35212708-91342023-08-015211812210.37184/lnjpc.2707-3521.5.9Ischemic Stroke and Acute Coronary Syndrome (ACS) in COVID-19 patients: Mechanisms and Role of CoagulopathySyed Mujtaba Azhar Bokhari0Muhammad Irfan Kaleem1Doctors Hospital and Medical Centre, Johar Town, Lahore, PakistanAnjum Clinic, Samanabad, Lahore, PakistanCOVID-19 has a devastating impact on patients not only due to the severity of pulmonary disease but also the multitude of other manifestations. We discuss here myocardial ischemia and stroke, associated with COVID-19, from a hyper coagulation perspective. Original studies, case reports, and systematic reviews from different databases were studied for this review article. Elevated inflammatory markers (e.g. ferritin, C reactive protein, interleukins, antiphospholipid antibodies) together with elevated D-dimer levels point to an inflammatory source of activation of the coagulation cascade. Furthermore, the features of macro and micro thrombi, because of dysregulated coagulation, point to local thrombosis as well as distant thrombo-embolism. Inflammation cascade and changes in coagulation markers leading to coagulopathy in COVID-19 patients emphasize the need to develop investigation techniques that can independently guide therapy.https://journals.lnh.edu.pk/lnjpc/pdf/45fd7d62-2b27-4721-99fe-c3e1e3cca32c.pdfcoagulationinflammatorycovidstrokeacute coronary syndrome (acs) |
| spellingShingle | Syed Mujtaba Azhar Bokhari Muhammad Irfan Kaleem Ischemic Stroke and Acute Coronary Syndrome (ACS) in COVID-19 patients: Mechanisms and Role of Coagulopathy Liaquat National Journal of Primary Care coagulation inflammatory covid stroke acute coronary syndrome (acs) |
| title | Ischemic Stroke and Acute Coronary Syndrome (ACS) in COVID-19 patients: Mechanisms and Role of Coagulopathy |
| title_full | Ischemic Stroke and Acute Coronary Syndrome (ACS) in COVID-19 patients: Mechanisms and Role of Coagulopathy |
| title_fullStr | Ischemic Stroke and Acute Coronary Syndrome (ACS) in COVID-19 patients: Mechanisms and Role of Coagulopathy |
| title_full_unstemmed | Ischemic Stroke and Acute Coronary Syndrome (ACS) in COVID-19 patients: Mechanisms and Role of Coagulopathy |
| title_short | Ischemic Stroke and Acute Coronary Syndrome (ACS) in COVID-19 patients: Mechanisms and Role of Coagulopathy |
| title_sort | ischemic stroke and acute coronary syndrome acs in covid 19 patients mechanisms and role of coagulopathy |
| topic | coagulation inflammatory covid stroke acute coronary syndrome (acs) |
| url | https://journals.lnh.edu.pk/lnjpc/pdf/45fd7d62-2b27-4721-99fe-c3e1e3cca32c.pdf |
| work_keys_str_mv | AT syedmujtabaazharbokhari ischemicstrokeandacutecoronarysyndromeacsincovid19patientsmechanismsandroleofcoagulopathy AT muhammadirfankaleem ischemicstrokeandacutecoronarysyndromeacsincovid19patientsmechanismsandroleofcoagulopathy |