Peptide Designs for Use in Caries Management: A Systematic Review
The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/4247 |
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| author | Olivia Lili Zhang John Yun Niu Ollie Yiru Yu May Lei Mei Nicholas Stephen Jakubovics Chun Hung Chu |
| author_facet | Olivia Lili Zhang John Yun Niu Ollie Yiru Yu May Lei Mei Nicholas Stephen Jakubovics Chun Hung Chu |
| author_sort | Olivia Lili Zhang |
| collection | DOAJ |
| description | The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in the included studies. This review identified 3592 publications, of which 62 were selected. Forty-seven studies reported 57 antimicrobial peptides. Among them, 31 studies (66%, 31/47) used the template-based design method; 9 studies (19%, 9/47) used the conjugation method; and 7 studies (15%, 7/47) used other methods, such as the synthetic combinatorial technology method, the de novo design method and cyclisation. Ten studies reported mineralising peptides. Seven of these (70%, 7/10) used the template-based design method, two (20%, 2/10) used the de novo design method, and one study (10%, 1/10) used the conjugation method. In addition, five studies developed their own peptides with antimicrobial and mineralising properties. These studies used the conjugation method. Our assessment for the risk of bias in the 62 reviewed studies showed that 44 publications (71%, 44/62) had a medium risk and that 3 publications had a low risk (5%, 3/62). The two most common methods for developing peptides for use in caries management that were used in these studies were the template-based design method and the conjugation method. |
| first_indexed | 2024-03-11T08:39:28Z |
| format | Article |
| id | doaj.art-322f393167dd446f99304ae54950808e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:39:28Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-322f393167dd446f99304ae54950808e2023-11-16T21:11:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244424710.3390/ijms24044247Peptide Designs for Use in Caries Management: A Systematic ReviewOlivia Lili Zhang0John Yun Niu1Ollie Yiru Yu2May Lei Mei3Nicholas Stephen Jakubovics4Chun Hung Chu5Faculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaFaculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaFaculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaFaculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaSchool of Dental Sciences, Newcastle University, Newcastle upon Tyne NE2 4BW, UKFaculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaThe objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in the included studies. This review identified 3592 publications, of which 62 were selected. Forty-seven studies reported 57 antimicrobial peptides. Among them, 31 studies (66%, 31/47) used the template-based design method; 9 studies (19%, 9/47) used the conjugation method; and 7 studies (15%, 7/47) used other methods, such as the synthetic combinatorial technology method, the de novo design method and cyclisation. Ten studies reported mineralising peptides. Seven of these (70%, 7/10) used the template-based design method, two (20%, 2/10) used the de novo design method, and one study (10%, 1/10) used the conjugation method. In addition, five studies developed their own peptides with antimicrobial and mineralising properties. These studies used the conjugation method. Our assessment for the risk of bias in the 62 reviewed studies showed that 44 publications (71%, 44/62) had a medium risk and that 3 publications had a low risk (5%, 3/62). The two most common methods for developing peptides for use in caries management that were used in these studies were the template-based design method and the conjugation method.https://www.mdpi.com/1422-0067/24/4/4247antimicrobialcariespeptidespreventionremineralisation |
| spellingShingle | Olivia Lili Zhang John Yun Niu Ollie Yiru Yu May Lei Mei Nicholas Stephen Jakubovics Chun Hung Chu Peptide Designs for Use in Caries Management: A Systematic Review International Journal of Molecular Sciences antimicrobial caries peptides prevention remineralisation |
| title | Peptide Designs for Use in Caries Management: A Systematic Review |
| title_full | Peptide Designs for Use in Caries Management: A Systematic Review |
| title_fullStr | Peptide Designs for Use in Caries Management: A Systematic Review |
| title_full_unstemmed | Peptide Designs for Use in Caries Management: A Systematic Review |
| title_short | Peptide Designs for Use in Caries Management: A Systematic Review |
| title_sort | peptide designs for use in caries management a systematic review |
| topic | antimicrobial caries peptides prevention remineralisation |
| url | https://www.mdpi.com/1422-0067/24/4/4247 |
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