Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures
Abstract Obesity contributes to physical comorbidities and mental health consequences. We explored whether physical activity could influence more than metabolic regulation and result in psychological benefits through the brain-gut microbiome (BGM) system in a population with high BMI. Fecal samples...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-37009-z |
| _version_ | 1797789760363692032 |
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| author | Michelle Guan Tien S. Dong Vishvak Subramanyam Yiming Guo Ravi R. Bhatt Allison Vaughan Robert L. Barry Arpana Gupta |
| author_facet | Michelle Guan Tien S. Dong Vishvak Subramanyam Yiming Guo Ravi R. Bhatt Allison Vaughan Robert L. Barry Arpana Gupta |
| author_sort | Michelle Guan |
| collection | DOAJ |
| description | Abstract Obesity contributes to physical comorbidities and mental health consequences. We explored whether physical activity could influence more than metabolic regulation and result in psychological benefits through the brain-gut microbiome (BGM) system in a population with high BMI. Fecal samples were obtained for 16 s rRNA profiling and fecal metabolomics, along with psychological and physical activity questionnaires. Whole brain resting-state functional MRI was acquired, and brain connectivity metrics were calculated. Higher physical activity was significantly associated with increased connectivity in inhibitory appetite control brain regions, while lower physical activity was associated with increased emotional regulation network connections. Higher physical activity was also associated with microbiome and metabolite signatures protective towards mental health and metabolic derangements. The greater resilience and coping, and lower levels of food addiction seen with higher physical activity, may be explained by BGM system differences. These novel findings provide an emphasis on the psychological and resilience benefits of physical activity, beyond metabolic regulation and these influences seem to be related to BGM interactions. |
| first_indexed | 2024-03-13T01:55:14Z |
| format | Article |
| id | doaj.art-32308dc866384725be4c7b7b0d214145 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T01:55:14Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-32308dc866384725be4c7b7b0d2141452023-07-02T11:16:29ZengNature PortfolioScientific Reports2045-23222023-06-0113112110.1038/s41598-023-37009-zImproved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signaturesMichelle Guan0Tien S. Dong1Vishvak Subramanyam2Yiming Guo3Ravi R. Bhatt4Allison Vaughan5Robert L. Barry6Arpana Gupta7David Geffen School of MedicineDavid Geffen School of MedicineUniversity of CaliforniaUniversity of CaliforniaImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine at USC, University of Southern CaliforniaDavid Geffen School of MedicineAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General HospitalDavid Geffen School of MedicineAbstract Obesity contributes to physical comorbidities and mental health consequences. We explored whether physical activity could influence more than metabolic regulation and result in psychological benefits through the brain-gut microbiome (BGM) system in a population with high BMI. Fecal samples were obtained for 16 s rRNA profiling and fecal metabolomics, along with psychological and physical activity questionnaires. Whole brain resting-state functional MRI was acquired, and brain connectivity metrics were calculated. Higher physical activity was significantly associated with increased connectivity in inhibitory appetite control brain regions, while lower physical activity was associated with increased emotional regulation network connections. Higher physical activity was also associated with microbiome and metabolite signatures protective towards mental health and metabolic derangements. The greater resilience and coping, and lower levels of food addiction seen with higher physical activity, may be explained by BGM system differences. These novel findings provide an emphasis on the psychological and resilience benefits of physical activity, beyond metabolic regulation and these influences seem to be related to BGM interactions.https://doi.org/10.1038/s41598-023-37009-z |
| spellingShingle | Michelle Guan Tien S. Dong Vishvak Subramanyam Yiming Guo Ravi R. Bhatt Allison Vaughan Robert L. Barry Arpana Gupta Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures Scientific Reports |
| title | Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures |
| title_full | Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures |
| title_fullStr | Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures |
| title_full_unstemmed | Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures |
| title_short | Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures |
| title_sort | improved psychosocial measures associated with physical activity may be explained by alterations in brain gut microbiome signatures |
| url | https://doi.org/10.1038/s41598-023-37009-z |
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