Comprehensive Understanding of Silicon-Nanowire Field-Effect Transistor Impedimetric Readout for Biomolecular Sensing
Impedance sensing with silicon nanowire field-effect transistors (SiNW-FETs) shows considerable potential for label-free detection of biomolecules. With this technique, it might be possible to overcome the Debye-screening limitation, a major problem of the classical potentiometric readout. We employ...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/1/39 |
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| author | Abhiroop Bhattacharjee Thanh Chien Nguyen Vivek Pachauri Sven Ingebrandt Xuan Thang Vu |
| author_facet | Abhiroop Bhattacharjee Thanh Chien Nguyen Vivek Pachauri Sven Ingebrandt Xuan Thang Vu |
| author_sort | Abhiroop Bhattacharjee |
| collection | DOAJ |
| description | Impedance sensing with silicon nanowire field-effect transistors (SiNW-FETs) shows considerable potential for label-free detection of biomolecules. With this technique, it might be possible to overcome the Debye-screening limitation, a major problem of the classical potentiometric readout. We employed an electronic circuit model in Simulation Program with Integrated Circuit Emphasis (SPICE) for SiNW-FETs to perform impedimetric measurements through SPICE simulations and quantitatively evaluate influences of various device parameters to the transfer function of the devices. Furthermore, we investigated how biomolecule binding to the surface of SiNW-FETs is influencing the impedance spectra. Based on mathematical analysis and simulation results, we proposed methods that could improve the impedimetric readout of SiNW-FET biosensors and make it more explicable. |
| first_indexed | 2024-03-10T13:35:36Z |
| format | Article |
| id | doaj.art-3230fc9440e046c28cdcd2e368552dc6 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T13:35:36Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-3230fc9440e046c28cdcd2e368552dc62023-11-21T07:29:42ZengMDPI AGMicromachines2072-666X2020-12-011213910.3390/mi12010039Comprehensive Understanding of Silicon-Nanowire Field-Effect Transistor Impedimetric Readout for Biomolecular SensingAbhiroop Bhattacharjee0Thanh Chien Nguyen1Vivek Pachauri2Sven Ingebrandt3Xuan Thang Vu4Institute of Materials in Electrical Engineering 1, RWTH Aachen University, Sommerfeldstraße 24, 52074 Aachen, GermanyDepartment of Informatics and Microsystem Technology, University of Applied Sciences Kaiserslautern, Amerikastrasse 1, 66482 Zweibrücken, GermanyInstitute of Materials in Electrical Engineering 1, RWTH Aachen University, Sommerfeldstraße 24, 52074 Aachen, GermanyInstitute of Materials in Electrical Engineering 1, RWTH Aachen University, Sommerfeldstraße 24, 52074 Aachen, GermanyInstitute of Materials in Electrical Engineering 1, RWTH Aachen University, Sommerfeldstraße 24, 52074 Aachen, GermanyImpedance sensing with silicon nanowire field-effect transistors (SiNW-FETs) shows considerable potential for label-free detection of biomolecules. With this technique, it might be possible to overcome the Debye-screening limitation, a major problem of the classical potentiometric readout. We employed an electronic circuit model in Simulation Program with Integrated Circuit Emphasis (SPICE) for SiNW-FETs to perform impedimetric measurements through SPICE simulations and quantitatively evaluate influences of various device parameters to the transfer function of the devices. Furthermore, we investigated how biomolecule binding to the surface of SiNW-FETs is influencing the impedance spectra. Based on mathematical analysis and simulation results, we proposed methods that could improve the impedimetric readout of SiNW-FET biosensors and make it more explicable.https://www.mdpi.com/2072-666X/12/1/39silicon-nanowire field-effect transistorimpedimetric readoutbiosensorssimulation program with integrated circuit emphasis (SPICE)transistor transfer function |
| spellingShingle | Abhiroop Bhattacharjee Thanh Chien Nguyen Vivek Pachauri Sven Ingebrandt Xuan Thang Vu Comprehensive Understanding of Silicon-Nanowire Field-Effect Transistor Impedimetric Readout for Biomolecular Sensing Micromachines silicon-nanowire field-effect transistor impedimetric readout biosensors simulation program with integrated circuit emphasis (SPICE) transistor transfer function |
| title | Comprehensive Understanding of Silicon-Nanowire Field-Effect Transistor Impedimetric Readout for Biomolecular Sensing |
| title_full | Comprehensive Understanding of Silicon-Nanowire Field-Effect Transistor Impedimetric Readout for Biomolecular Sensing |
| title_fullStr | Comprehensive Understanding of Silicon-Nanowire Field-Effect Transistor Impedimetric Readout for Biomolecular Sensing |
| title_full_unstemmed | Comprehensive Understanding of Silicon-Nanowire Field-Effect Transistor Impedimetric Readout for Biomolecular Sensing |
| title_short | Comprehensive Understanding of Silicon-Nanowire Field-Effect Transistor Impedimetric Readout for Biomolecular Sensing |
| title_sort | comprehensive understanding of silicon nanowire field effect transistor impedimetric readout for biomolecular sensing |
| topic | silicon-nanowire field-effect transistor impedimetric readout biosensors simulation program with integrated circuit emphasis (SPICE) transistor transfer function |
| url | https://www.mdpi.com/2072-666X/12/1/39 |
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