Preoperative systemic immune‐inflammation index for predicting the prognosis of thymoma with radical resection
Abstract Background To investigate the clinical significance of preoperative systemic immune‐inflammation index (SII) in patients with thymoma who underwent radical resection. Methods This retrospective study involved 425 patients with thymoma who underwent radical resection at the First Affiliated...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14854 |
| _version_ | 1797835804360310784 |
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| author | Qifan Li Yiwei Pu Zetian Gong Yue Yu Wei Sun Zhike Cheng Wei Wang Jun Zhao |
| author_facet | Qifan Li Yiwei Pu Zetian Gong Yue Yu Wei Sun Zhike Cheng Wei Wang Jun Zhao |
| author_sort | Qifan Li |
| collection | DOAJ |
| description | Abstract Background To investigate the clinical significance of preoperative systemic immune‐inflammation index (SII) in patients with thymoma who underwent radical resection. Methods This retrospective study involved 425 patients with thymoma who underwent radical resection at the First Affiliated Hospital of Nanjing Medical University between September 1, 2008 and December 30, 2019. Data regarding routine preoperative blood tests and clinical features were collected to calculate and analyze the SII, platelet‐to‐lymphocyte ratio (PLR), and neutrophil‐to‐lymphocyte ratio (NLR). Results Univariate analysis indicated that age (p = 0.021), tumor size (p = 0.003), extended resection (p < 0.001), Masaoka‐Koga stage (p < 0.001), PLR (p = 0.012), NLR (p = 0.041), and SII (p = 0.003) were related to patient prognosis. A higher SII (>345.83) was a significant independent prognostic factor in this cohort (p = 0.001, HR = 5.756, 95% CI: 2.144–15.457). Multivariate analysis showed that a high PLR was significantly associated with overall survival (OS) (p = 0.008, HR = 3.29, 95% CI: 1.371–7.896), while a high NLR was a significant independent prognostic factor for shorter OS (p = 0.024, HR = 2.654, 95% CI: 1.138–6.19). SII had an area under the curve (AUC) of 70.6% (AUC = 0.706) exceeding the predictive value for PLR (AUC = 0.678) and NLR (AUC = 0.654). Conclusion Preoperative SII can predict the prognosis of thymoma patients who have undergone radical resection but further multicenter prospective studies are needed to investigate the role of SII in thymoma. |
| first_indexed | 2024-04-09T14:58:20Z |
| format | Article |
| id | doaj.art-32316466e82b432eb876d0487f4db0c5 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-09T14:58:20Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-32316466e82b432eb876d0487f4db0c52023-05-01T23:44:44ZengWileyThoracic Cancer1759-77061759-77142023-05-0114131192120010.1111/1759-7714.14854Preoperative systemic immune‐inflammation index for predicting the prognosis of thymoma with radical resectionQifan Li0Yiwei Pu1Zetian Gong2Yue Yu3Wei Sun4Zhike Cheng5Wei Wang6Jun Zhao7Department of Thoracic Surgery The First Affiliated Hospital of Soochow University Suzhou ChinaDepartment of Cardiothoracic Surgery Children's Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Soochow University Suzhou ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Soochow University Suzhou ChinaAbstract Background To investigate the clinical significance of preoperative systemic immune‐inflammation index (SII) in patients with thymoma who underwent radical resection. Methods This retrospective study involved 425 patients with thymoma who underwent radical resection at the First Affiliated Hospital of Nanjing Medical University between September 1, 2008 and December 30, 2019. Data regarding routine preoperative blood tests and clinical features were collected to calculate and analyze the SII, platelet‐to‐lymphocyte ratio (PLR), and neutrophil‐to‐lymphocyte ratio (NLR). Results Univariate analysis indicated that age (p = 0.021), tumor size (p = 0.003), extended resection (p < 0.001), Masaoka‐Koga stage (p < 0.001), PLR (p = 0.012), NLR (p = 0.041), and SII (p = 0.003) were related to patient prognosis. A higher SII (>345.83) was a significant independent prognostic factor in this cohort (p = 0.001, HR = 5.756, 95% CI: 2.144–15.457). Multivariate analysis showed that a high PLR was significantly associated with overall survival (OS) (p = 0.008, HR = 3.29, 95% CI: 1.371–7.896), while a high NLR was a significant independent prognostic factor for shorter OS (p = 0.024, HR = 2.654, 95% CI: 1.138–6.19). SII had an area under the curve (AUC) of 70.6% (AUC = 0.706) exceeding the predictive value for PLR (AUC = 0.678) and NLR (AUC = 0.654). Conclusion Preoperative SII can predict the prognosis of thymoma patients who have undergone radical resection but further multicenter prospective studies are needed to investigate the role of SII in thymoma.https://doi.org/10.1111/1759-7714.14854NLRPLRprognosisSIIthymoma |
| spellingShingle | Qifan Li Yiwei Pu Zetian Gong Yue Yu Wei Sun Zhike Cheng Wei Wang Jun Zhao Preoperative systemic immune‐inflammation index for predicting the prognosis of thymoma with radical resection Thoracic Cancer NLR PLR prognosis SII thymoma |
| title | Preoperative systemic immune‐inflammation index for predicting the prognosis of thymoma with radical resection |
| title_full | Preoperative systemic immune‐inflammation index for predicting the prognosis of thymoma with radical resection |
| title_fullStr | Preoperative systemic immune‐inflammation index for predicting the prognosis of thymoma with radical resection |
| title_full_unstemmed | Preoperative systemic immune‐inflammation index for predicting the prognosis of thymoma with radical resection |
| title_short | Preoperative systemic immune‐inflammation index for predicting the prognosis of thymoma with radical resection |
| title_sort | preoperative systemic immune inflammation index for predicting the prognosis of thymoma with radical resection |
| topic | NLR PLR prognosis SII thymoma |
| url | https://doi.org/10.1111/1759-7714.14854 |
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