Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic Study
Background: Few studies examined the effects of combined motor and cognitive rehabilitation in patients with multiple sclerosis (MS). The present prospective, multicenter, observational study aimed to determine the efficacy of an integrated cognitive and neuromotor rehabilitation program versus a tr...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2018.00196/full |
| _version_ | 1818178197800353792 |
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| author | Anna M. Barbarulo Anna M. Barbarulo Giacomo Lus Giacomo Lus Elisabetta Signoriello Elisabetta Signoriello Luigi Trojano Luigi Trojano Dario Grossi Dario Grossi Mariateresa Esposito Teresa Costabile Roberta Lanzillo Francesco Saccà Vincenzo Brescia Morra Giovannina Conchiglia |
| author_facet | Anna M. Barbarulo Anna M. Barbarulo Giacomo Lus Giacomo Lus Elisabetta Signoriello Elisabetta Signoriello Luigi Trojano Luigi Trojano Dario Grossi Dario Grossi Mariateresa Esposito Teresa Costabile Roberta Lanzillo Francesco Saccà Vincenzo Brescia Morra Giovannina Conchiglia |
| author_sort | Anna M. Barbarulo |
| collection | DOAJ |
| description | Background: Few studies examined the effects of combined motor and cognitive rehabilitation in patients with multiple sclerosis (MS). The present prospective, multicenter, observational study aimed to determine the efficacy of an integrated cognitive and neuromotor rehabilitation program versus a traditional neuromotor training on walking, balance, cognition and emotional functioning in MS patients.Methods: Sixty three MS patients were selected and assigned either to the Integrated Treatment Group (ITG; n = 32), receiving neuropsychological treatment (performed by ERICA software and paper–pencil tasks) complemented by conventional neuromotor rehabilitation, or to the Motor Treatment Group (n = 31) receiving neuromotor rehabilitation only. The intervention included two 60-min sessions per week for 24 weeks. At baseline and at end of the training all patients underwent a wide-range neuropsychological, psychological/emotional, and motor assessment.Results: At baseline the two groups did not differ for demographic, neuropsychological, psychological/emotional, and motor features significantly. After rehabilitation, only ITG group significantly (p-corrected for False Discovery Rate) improved on test tapping spatial memory, attention and cognitive flexibility, as well as on scales assessing depression and motor performance (balance and gait). A regression analysis showed that neuropsychological and motor improvement was not related to improvements in fatigue and depression.Conclusion: The present study demonstrated positive effects in emotional, motor, and cognitive aspects in MS patients who received an integrated cognitive and neuromotor training. Overall, results are supportive of interventions combining motor and cognitive training for MS. |
| first_indexed | 2024-12-11T20:44:09Z |
| format | Article |
| id | doaj.art-3234480a05e94bb1afd8ee0780fae5cc |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-11T20:44:09Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-3234480a05e94bb1afd8ee0780fae5cc2022-12-22T00:51:25ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532018-09-011210.3389/fnbeh.2018.00196403964Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic StudyAnna M. Barbarulo0Anna M. Barbarulo1Giacomo Lus2Giacomo Lus3Elisabetta Signoriello4Elisabetta Signoriello5Luigi Trojano6Luigi Trojano7Dario Grossi8Dario Grossi9Mariateresa Esposito10Teresa Costabile11Roberta Lanzillo12Francesco Saccà13Vincenzo Brescia Morra14Giovannina Conchiglia15Multiple Sclerosis Center, II Division of Neurology, Department of Surgical Medical Science, Neurological, Metabolic and Aging, University of Campania Luigi Vanvitelli, Naples, ItalyInteruniversity Center for Research in Neurosciences, University of Campania Luigi Vanvitelli, Naples, ItalyMultiple Sclerosis Center, II Division of Neurology, Department of Surgical Medical Science, Neurological, Metabolic and Aging, University of Campania Luigi Vanvitelli, Naples, ItalyInteruniversity Center for Research in Neurosciences, University of Campania Luigi Vanvitelli, Naples, ItalyMultiple Sclerosis Center, II Division of Neurology, Department of Surgical Medical Science, Neurological, Metabolic and Aging, University of Campania Luigi Vanvitelli, Naples, ItalyInteruniversity Center for Research in Neurosciences, University of Campania Luigi Vanvitelli, Naples, ItalyInteruniversity Center for Research in Neurosciences, University of Campania Luigi Vanvitelli, Naples, ItalyDepartment of Psychology, University of Campania Luigi Vanvitelli, Caserta, ItalyInteruniversity Center for Research in Neurosciences, University of Campania Luigi Vanvitelli, Naples, ItalyDepartment of Psychology, University of Campania Luigi Vanvitelli, Caserta, ItalyDepartment of Psychology, University of Campania Luigi Vanvitelli, Caserta, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, ItalyDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, ItalyFoundation Villa Camaldoli, Rehabilitation Clinic Alma Mater S.p.A., Naples, ItalyBackground: Few studies examined the effects of combined motor and cognitive rehabilitation in patients with multiple sclerosis (MS). The present prospective, multicenter, observational study aimed to determine the efficacy of an integrated cognitive and neuromotor rehabilitation program versus a traditional neuromotor training on walking, balance, cognition and emotional functioning in MS patients.Methods: Sixty three MS patients were selected and assigned either to the Integrated Treatment Group (ITG; n = 32), receiving neuropsychological treatment (performed by ERICA software and paper–pencil tasks) complemented by conventional neuromotor rehabilitation, or to the Motor Treatment Group (n = 31) receiving neuromotor rehabilitation only. The intervention included two 60-min sessions per week for 24 weeks. At baseline and at end of the training all patients underwent a wide-range neuropsychological, psychological/emotional, and motor assessment.Results: At baseline the two groups did not differ for demographic, neuropsychological, psychological/emotional, and motor features significantly. After rehabilitation, only ITG group significantly (p-corrected for False Discovery Rate) improved on test tapping spatial memory, attention and cognitive flexibility, as well as on scales assessing depression and motor performance (balance and gait). A regression analysis showed that neuropsychological and motor improvement was not related to improvements in fatigue and depression.Conclusion: The present study demonstrated positive effects in emotional, motor, and cognitive aspects in MS patients who received an integrated cognitive and neuromotor training. Overall, results are supportive of interventions combining motor and cognitive training for MS.https://www.frontiersin.org/article/10.3389/fnbeh.2018.00196/fullmultiple sclerosiscognitive rehabilitationneuromotor rehabilitationbrain plasticitycognitive motor interference |
| spellingShingle | Anna M. Barbarulo Anna M. Barbarulo Giacomo Lus Giacomo Lus Elisabetta Signoriello Elisabetta Signoriello Luigi Trojano Luigi Trojano Dario Grossi Dario Grossi Mariateresa Esposito Teresa Costabile Roberta Lanzillo Francesco Saccà Vincenzo Brescia Morra Giovannina Conchiglia Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic Study Frontiers in Behavioral Neuroscience multiple sclerosis cognitive rehabilitation neuromotor rehabilitation brain plasticity cognitive motor interference |
| title | Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic Study |
| title_full | Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic Study |
| title_fullStr | Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic Study |
| title_full_unstemmed | Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic Study |
| title_short | Integrated Cognitive and Neuromotor Rehabilitation in Multiple Sclerosis: A Pragmatic Study |
| title_sort | integrated cognitive and neuromotor rehabilitation in multiple sclerosis a pragmatic study |
| topic | multiple sclerosis cognitive rehabilitation neuromotor rehabilitation brain plasticity cognitive motor interference |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2018.00196/full |
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