Advances of exosomal miRNAs in the diagnosis and treatment of ovarian cancer
Abstract Ovarian cancer is a tumor with the highest fatalities among female malignant tumors. This disease has no typical symptoms in its early stage, and most of the patients are in an advanced stage when being treated. The treatment effect is poor and it is easy to develop chemotherapy resistance....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Springer
2023-05-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-023-00674-7 |
| _version_ | 1827948039567835136 |
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| author | Jun Xiong Fen Fu Feng Yu Xiaoju He |
| author_facet | Jun Xiong Fen Fu Feng Yu Xiaoju He |
| author_sort | Jun Xiong |
| collection | DOAJ |
| description | Abstract Ovarian cancer is a tumor with the highest fatalities among female malignant tumors. This disease has no typical symptoms in its early stage, and most of the patients are in an advanced stage when being treated. The treatment effect is poor and it is easy to develop chemotherapy resistance. Therefore, it is particularly urgent to clarify the pathogenesis of ovarian cancer, explore its early diagnosis of biomarkers, and discover new treatment methods. As a carrier of intercellular information and genetic material transfer, exosomes are widely distributed in body fluids (e.g. blood and urine), which are regarded as latent tumor markers and take effects on tumor occurrence and invasion. Several articles have recently signified that exosomal miRNAs are widely implicated in the formation of the ovarian cancer tumor microenvironment, disease initiation and progression, and the generation of chemotherapy resistance. This article reviews the research on exosomal miRNAs in ovarian cancer. |
| first_indexed | 2024-04-09T12:48:09Z |
| format | Article |
| id | doaj.art-3235c00bc7264cb5b198c29b8412e7e0 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-09T12:48:09Z |
| publishDate | 2023-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-3235c00bc7264cb5b198c29b8412e7e02023-05-14T11:20:37ZengSpringerDiscover Oncology2730-60112023-05-0114111010.1007/s12672-023-00674-7Advances of exosomal miRNAs in the diagnosis and treatment of ovarian cancerJun Xiong0Fen Fu1Feng Yu2Xiaoju He3Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang UniversityAbstract Ovarian cancer is a tumor with the highest fatalities among female malignant tumors. This disease has no typical symptoms in its early stage, and most of the patients are in an advanced stage when being treated. The treatment effect is poor and it is easy to develop chemotherapy resistance. Therefore, it is particularly urgent to clarify the pathogenesis of ovarian cancer, explore its early diagnosis of biomarkers, and discover new treatment methods. As a carrier of intercellular information and genetic material transfer, exosomes are widely distributed in body fluids (e.g. blood and urine), which are regarded as latent tumor markers and take effects on tumor occurrence and invasion. Several articles have recently signified that exosomal miRNAs are widely implicated in the formation of the ovarian cancer tumor microenvironment, disease initiation and progression, and the generation of chemotherapy resistance. This article reviews the research on exosomal miRNAs in ovarian cancer.https://doi.org/10.1007/s12672-023-00674-7Ovarian cancerExosomal miRNAsTumor microenvironmentHallmark |
| spellingShingle | Jun Xiong Fen Fu Feng Yu Xiaoju He Advances of exosomal miRNAs in the diagnosis and treatment of ovarian cancer Discover Oncology Ovarian cancer Exosomal miRNAs Tumor microenvironment Hallmark |
| title | Advances of exosomal miRNAs in the diagnosis and treatment of ovarian cancer |
| title_full | Advances of exosomal miRNAs in the diagnosis and treatment of ovarian cancer |
| title_fullStr | Advances of exosomal miRNAs in the diagnosis and treatment of ovarian cancer |
| title_full_unstemmed | Advances of exosomal miRNAs in the diagnosis and treatment of ovarian cancer |
| title_short | Advances of exosomal miRNAs in the diagnosis and treatment of ovarian cancer |
| title_sort | advances of exosomal mirnas in the diagnosis and treatment of ovarian cancer |
| topic | Ovarian cancer Exosomal miRNAs Tumor microenvironment Hallmark |
| url | https://doi.org/10.1007/s12672-023-00674-7 |
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