Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report
SH Talib, SR Bhattu, R Bhattu, SG Deshpande, DB Dahiphale Department of Medicine and Nephrology, MGM Medical College and Hospital, Aurangabad, Maharashtra, India Abstract: We report a rare case of dengue fever triggering systemic lupus erythematosus and lupus nephritis. The patient presented herself...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2013-10-01
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| Series: | International Medical Case Reports Journal |
| Online Access: | http://www.dovepress.com/dengue-fever-triggering-systemic-lupus-erythematosus-and-lupus-nephrit-a14850 |
| _version_ | 1818112193485340672 |
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| author | Talib SH Bhattu SR Bhattu R Deshpande SG Dahiphale DB |
| author_facet | Talib SH Bhattu SR Bhattu R Deshpande SG Dahiphale DB |
| author_sort | Talib SH |
| collection | DOAJ |
| description | SH Talib, SR Bhattu, R Bhattu, SG Deshpande, DB Dahiphale Department of Medicine and Nephrology, MGM Medical College and Hospital, Aurangabad, Maharashtra, India Abstract: We report a rare case of dengue fever triggering systemic lupus erythematosus and lupus nephritis. The patient presented herself during a large outbreak of dengue fever in December 2012 in Maharashtra, India. The diagnosis of dengue fever was confirmed by the presence of NS-1 antigen during the first few days of febrile illness. Eight weeks later, kidney tissue biopsy studies revealed evidence of lupus nephritis on microscopic examination and immunofluorescence. The report interpreted it as focal proliferative glomerulonephritis and segmental sclerosis (Stage IIIC). The case was also found positive for perinuclear antineutrophil cytoplasmic antibodies by indirect immunofluorescence assay. An active and effective management of a case essentially calls for clear perception of differentiating dengue-induced lupus flare, antineutrophil cytoplasmic antibody-related nephropathy, and/or dengue-induced de-novo lupus disease. Dengue viremia may be the trigger for immune complex formation in patients who are predisposed to developing autoimmune diseases. The present case explains the importance of considering the diagnosis of dengue-related lupus nephritis as an atypical occurrence in appropriate situations, as in this case. It would not be improper to regard this escalating disease as an expanded feature of dengue. Keywords: kidney biopsy, glomerulonephritis, segmental sclerosis, lupus flare, dengue viremia, autoimmune, de-novo lupus nephritis |
| first_indexed | 2024-12-11T03:15:03Z |
| format | Article |
| id | doaj.art-3235cad13d1443aa94ee7c2b005d11ef |
| institution | Directory Open Access Journal |
| issn | 1179-142X |
| language | English |
| last_indexed | 2024-12-11T03:15:03Z |
| publishDate | 2013-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj.art-3235cad13d1443aa94ee7c2b005d11ef2022-12-22T01:22:47ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2013-10-012013default7175Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case reportTalib SHBhattu SRBhattu RDeshpande SGDahiphale DBSH Talib, SR Bhattu, R Bhattu, SG Deshpande, DB Dahiphale Department of Medicine and Nephrology, MGM Medical College and Hospital, Aurangabad, Maharashtra, India Abstract: We report a rare case of dengue fever triggering systemic lupus erythematosus and lupus nephritis. The patient presented herself during a large outbreak of dengue fever in December 2012 in Maharashtra, India. The diagnosis of dengue fever was confirmed by the presence of NS-1 antigen during the first few days of febrile illness. Eight weeks later, kidney tissue biopsy studies revealed evidence of lupus nephritis on microscopic examination and immunofluorescence. The report interpreted it as focal proliferative glomerulonephritis and segmental sclerosis (Stage IIIC). The case was also found positive for perinuclear antineutrophil cytoplasmic antibodies by indirect immunofluorescence assay. An active and effective management of a case essentially calls for clear perception of differentiating dengue-induced lupus flare, antineutrophil cytoplasmic antibody-related nephropathy, and/or dengue-induced de-novo lupus disease. Dengue viremia may be the trigger for immune complex formation in patients who are predisposed to developing autoimmune diseases. The present case explains the importance of considering the diagnosis of dengue-related lupus nephritis as an atypical occurrence in appropriate situations, as in this case. It would not be improper to regard this escalating disease as an expanded feature of dengue. Keywords: kidney biopsy, glomerulonephritis, segmental sclerosis, lupus flare, dengue viremia, autoimmune, de-novo lupus nephritishttp://www.dovepress.com/dengue-fever-triggering-systemic-lupus-erythematosus-and-lupus-nephrit-a14850 |
| spellingShingle | Talib SH Bhattu SR Bhattu R Deshpande SG Dahiphale DB Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report International Medical Case Reports Journal |
| title | Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report |
| title_full | Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report |
| title_fullStr | Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report |
| title_full_unstemmed | Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report |
| title_short | Dengue fever triggering systemic lupus erythematosus and lupus nephritis: a case report |
| title_sort | dengue fever triggering systemic lupus erythematosus and lupus nephritis a case report |
| url | http://www.dovepress.com/dengue-fever-triggering-systemic-lupus-erythematosus-and-lupus-nephrit-a14850 |
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