The Application of Evidence-Based Medicine in Individualized Medicine
The fundamental aim of healthcare is to improve overall health of the population by providing state-of-the-art healthcare for individuals at an affordable cost. The foundation for this system is largely referred to as “evidence-based medicine”. Too often, evidence-based medicine is based solely on s...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/7/1793 |
| _version_ | 1797590151069696000 |
|---|---|
| author | Peter Van de Vliet Tobias Sprenger Linde F. C. Kampers Jennifer Makalowski Volker Schirrmacher Wilfried Stücker Stefaan W. Van Gool |
| author_facet | Peter Van de Vliet Tobias Sprenger Linde F. C. Kampers Jennifer Makalowski Volker Schirrmacher Wilfried Stücker Stefaan W. Van Gool |
| author_sort | Peter Van de Vliet |
| collection | DOAJ |
| description | The fundamental aim of healthcare is to improve overall health of the population by providing state-of-the-art healthcare for individuals at an affordable cost. The foundation for this system is largely referred to as “evidence-based medicine”. Too often, evidence-based medicine is based solely on so-called “best research evidence”, collected through randomized controlled trials while disregarding clinical expertise and patient expectations. As healthcare gravitates towards personalized and individualized medicine, such external clinical (research) evidence can inform, but never replace, individual clinical expertise. This applies in particular to orphan diseases, for which clinical trials are methodologically particularly problematic, and evidence derived from them is often questionable. Evidence-based medicine constitutes a complex process to allow doctors and patients to select the best possible solutions for each individual based on rapidly developing new therapeutic directions. This requires a revisit of the foundations of evidence-based medicine. A proposition as to how to manage evidence-based data in individualized immune-oncology is presented here. |
| first_indexed | 2024-03-11T01:16:25Z |
| format | Article |
| id | doaj.art-32364eacfe6544a4b50fa61eadd2f743 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T01:16:25Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-32364eacfe6544a4b50fa61eadd2f7432023-11-18T18:25:03ZengMDPI AGBiomedicines2227-90592023-06-01117179310.3390/biomedicines11071793The Application of Evidence-Based Medicine in Individualized MedicinePeter Van de Vliet0Tobias Sprenger1Linde F. C. Kampers2Jennifer Makalowski3Volker Schirrmacher4Wilfried Stücker5Stefaan W. Van Gool6Immune-Oncological Centre Cologne (IOZK), D-50674 Cologne, GermanyImmune-Oncological Centre Cologne (IOZK), D-50674 Cologne, GermanyImmune-Oncological Centre Cologne (IOZK), D-50674 Cologne, GermanyImmune-Oncological Centre Cologne (IOZK), D-50674 Cologne, GermanyImmune-Oncological Centre Cologne (IOZK), D-50674 Cologne, GermanyImmune-Oncological Centre Cologne (IOZK), D-50674 Cologne, GermanyImmune-Oncological Centre Cologne (IOZK), D-50674 Cologne, GermanyThe fundamental aim of healthcare is to improve overall health of the population by providing state-of-the-art healthcare for individuals at an affordable cost. The foundation for this system is largely referred to as “evidence-based medicine”. Too often, evidence-based medicine is based solely on so-called “best research evidence”, collected through randomized controlled trials while disregarding clinical expertise and patient expectations. As healthcare gravitates towards personalized and individualized medicine, such external clinical (research) evidence can inform, but never replace, individual clinical expertise. This applies in particular to orphan diseases, for which clinical trials are methodologically particularly problematic, and evidence derived from them is often questionable. Evidence-based medicine constitutes a complex process to allow doctors and patients to select the best possible solutions for each individual based on rapidly developing new therapeutic directions. This requires a revisit of the foundations of evidence-based medicine. A proposition as to how to manage evidence-based data in individualized immune-oncology is presented here.https://www.mdpi.com/2227-9059/11/7/1793evidence-based medicinereal-world dataimmune-oncologyindividualized treatmentclinical evidencehealth-related quality of life |
| spellingShingle | Peter Van de Vliet Tobias Sprenger Linde F. C. Kampers Jennifer Makalowski Volker Schirrmacher Wilfried Stücker Stefaan W. Van Gool The Application of Evidence-Based Medicine in Individualized Medicine Biomedicines evidence-based medicine real-world data immune-oncology individualized treatment clinical evidence health-related quality of life |
| title | The Application of Evidence-Based Medicine in Individualized Medicine |
| title_full | The Application of Evidence-Based Medicine in Individualized Medicine |
| title_fullStr | The Application of Evidence-Based Medicine in Individualized Medicine |
| title_full_unstemmed | The Application of Evidence-Based Medicine in Individualized Medicine |
| title_short | The Application of Evidence-Based Medicine in Individualized Medicine |
| title_sort | application of evidence based medicine in individualized medicine |
| topic | evidence-based medicine real-world data immune-oncology individualized treatment clinical evidence health-related quality of life |
| url | https://www.mdpi.com/2227-9059/11/7/1793 |
| work_keys_str_mv | AT petervandevliet theapplicationofevidencebasedmedicineinindividualizedmedicine AT tobiassprenger theapplicationofevidencebasedmedicineinindividualizedmedicine AT lindefckampers theapplicationofevidencebasedmedicineinindividualizedmedicine AT jennifermakalowski theapplicationofevidencebasedmedicineinindividualizedmedicine AT volkerschirrmacher theapplicationofevidencebasedmedicineinindividualizedmedicine AT wilfriedstucker theapplicationofevidencebasedmedicineinindividualizedmedicine AT stefaanwvangool theapplicationofevidencebasedmedicineinindividualizedmedicine AT petervandevliet applicationofevidencebasedmedicineinindividualizedmedicine AT tobiassprenger applicationofevidencebasedmedicineinindividualizedmedicine AT lindefckampers applicationofevidencebasedmedicineinindividualizedmedicine AT jennifermakalowski applicationofevidencebasedmedicineinindividualizedmedicine AT volkerschirrmacher applicationofevidencebasedmedicineinindividualizedmedicine AT wilfriedstucker applicationofevidencebasedmedicineinindividualizedmedicine AT stefaanwvangool applicationofevidencebasedmedicineinindividualizedmedicine |