Preparation of stable enteric folic acid-loaded microfiber using the electrospinning method
Objective(s): Folic acid is an essential vitamin, labile to hydrolysis in the acidic environment of the stomach with low water solubility and bioavailability. In order to solve these problems, enteric oral folic acid-loaded microfibers with a pH-sensitive polymer by electrospinning method were prepa...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-03-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_19866_9769e59371d56dfb368a3e943c87292a.pdf |
| _version_ | 1811272554335174656 |
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| author | Abbas Akhgari Pariya Iraji Niloufar Rahiman Akram Hasanzade Farouji Mohammadreza Abbaspour |
| author_facet | Abbas Akhgari Pariya Iraji Niloufar Rahiman Akram Hasanzade Farouji Mohammadreza Abbaspour |
| author_sort | Abbas Akhgari |
| collection | DOAJ |
| description | Objective(s): Folic acid is an essential vitamin, labile to hydrolysis in the acidic environment of the stomach with low water solubility and bioavailability. In order to solve these problems, enteric oral folic acid-loaded microfibers with a pH-sensitive polymer by electrospinning method were prepared.Materials and Methods: Electrospinning was performed at different folic acid ratios and voltages. Fibers were evaluated in terms of mechanical strength, acidic resistance, and drug release. Additionally, DSC (Differential Scanning Calorimetry), FTIR (Fourier-transform infrared spectroscopy), and XRD (X-ray diffraction) analyses were performed on the optimal formulation. Results: Drug ratio and voltage had a considerable effect on fibers’ entrapment efficiency, acid resistance, and mechanical strength. Based on the obtained results, the optimum formulation containing 1.25% of the drug/polymer was prepared at 18 kV. The entrapment efficiency of the optimal sample was above 90% with an acid resistance of higher than 70%. The tensile test confirmed the high mechanical properties of the optimum microfiber. DSC and XRD tests indicated that folic acid was converted to an amorphous form in the fiber structure and the FTIR test confirmed the formation of a chemical bond between the drug and the polymer. The release of the drug from the optimal fiber was about 90% in 60 min.Conclusion: In conclusion, the optimal formulation of folic acid with proper mechanical properties can be used as a candidate dosage form for further bioavailability investigations. |
| first_indexed | 2024-04-12T22:42:24Z |
| format | Article |
| id | doaj.art-32371d2a727146fd8d6255094ec1611c |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-12T22:42:24Z |
| publishDate | 2022-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-32371d2a727146fd8d6255094ec1611c2022-12-22T03:13:39ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742022-03-0125340541310.22038/ijbms.2022.61563.1362519866Preparation of stable enteric folic acid-loaded microfiber using the electrospinning methodAbbas Akhgari0Pariya Iraji1Niloufar Rahiman2Akram Hasanzade Farouji3Mohammadreza Abbaspour4Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranNanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranObjective(s): Folic acid is an essential vitamin, labile to hydrolysis in the acidic environment of the stomach with low water solubility and bioavailability. In order to solve these problems, enteric oral folic acid-loaded microfibers with a pH-sensitive polymer by electrospinning method were prepared.Materials and Methods: Electrospinning was performed at different folic acid ratios and voltages. Fibers were evaluated in terms of mechanical strength, acidic resistance, and drug release. Additionally, DSC (Differential Scanning Calorimetry), FTIR (Fourier-transform infrared spectroscopy), and XRD (X-ray diffraction) analyses were performed on the optimal formulation. Results: Drug ratio and voltage had a considerable effect on fibers’ entrapment efficiency, acid resistance, and mechanical strength. Based on the obtained results, the optimum formulation containing 1.25% of the drug/polymer was prepared at 18 kV. The entrapment efficiency of the optimal sample was above 90% with an acid resistance of higher than 70%. The tensile test confirmed the high mechanical properties of the optimum microfiber. DSC and XRD tests indicated that folic acid was converted to an amorphous form in the fiber structure and the FTIR test confirmed the formation of a chemical bond between the drug and the polymer. The release of the drug from the optimal fiber was about 90% in 60 min.Conclusion: In conclusion, the optimal formulation of folic acid with proper mechanical properties can be used as a candidate dosage form for further bioavailability investigations.https://ijbms.mums.ac.ir/article_19866_9769e59371d56dfb368a3e943c87292a.pdfelectrospinningentericeudragitfolic acidmicrofiber |
| spellingShingle | Abbas Akhgari Pariya Iraji Niloufar Rahiman Akram Hasanzade Farouji Mohammadreza Abbaspour Preparation of stable enteric folic acid-loaded microfiber using the electrospinning method Iranian Journal of Basic Medical Sciences electrospinning enteric eudragit folic acid microfiber |
| title | Preparation of stable enteric folic acid-loaded microfiber using the electrospinning method |
| title_full | Preparation of stable enteric folic acid-loaded microfiber using the electrospinning method |
| title_fullStr | Preparation of stable enteric folic acid-loaded microfiber using the electrospinning method |
| title_full_unstemmed | Preparation of stable enteric folic acid-loaded microfiber using the electrospinning method |
| title_short | Preparation of stable enteric folic acid-loaded microfiber using the electrospinning method |
| title_sort | preparation of stable enteric folic acid loaded microfiber using the electrospinning method |
| topic | electrospinning enteric eudragit folic acid microfiber |
| url | https://ijbms.mums.ac.ir/article_19866_9769e59371d56dfb368a3e943c87292a.pdf |
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