The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases
The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/2/721 |
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| author | Youssof Eshac Rachel L. Redfern Vinay Kumar Aakalu |
| author_facet | Youssof Eshac Rachel L. Redfern Vinay Kumar Aakalu |
| author_sort | Youssof Eshac |
| collection | DOAJ |
| description | The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus on antimicrobial peptides and the role they play in the immune response of the ocular surface during healthy states and dry eye diseases. Antimicrobial peptides are of special interest to the study of the ocular surface because of their various roles that include microbial threat neutralization, wound healing, and immune modulation. This review explores current literature on antimicrobial peptides in ocular surface diseases and discusses their therapeutic potential in ocular surface diseases and dry eye. |
| first_indexed | 2024-03-09T04:58:51Z |
| format | Article |
| id | doaj.art-323c050637e74a678a7b138bf839838d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:58:51Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-323c050637e74a678a7b138bf839838d2023-12-03T13:01:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122272110.3390/ijms22020721The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye DiseasesYoussof Eshac0Rachel L. Redfern1Vinay Kumar Aakalu2Faculty of Medicine, Alexandria University, Alexandria 21131, EgyptThe Ocular Surface Institute, College of Optometry, University of Houston, Houston, TX 77204, USADepartment of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USAThe ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus on antimicrobial peptides and the role they play in the immune response of the ocular surface during healthy states and dry eye diseases. Antimicrobial peptides are of special interest to the study of the ocular surface because of their various roles that include microbial threat neutralization, wound healing, and immune modulation. This review explores current literature on antimicrobial peptides in ocular surface diseases and discusses their therapeutic potential in ocular surface diseases and dry eye.https://www.mdpi.com/1422-0067/22/2/721ocular surface diseaseantimicrobial peptideinnate immune systemdry eye disease |
| spellingShingle | Youssof Eshac Rachel L. Redfern Vinay Kumar Aakalu The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases International Journal of Molecular Sciences ocular surface disease antimicrobial peptide innate immune system dry eye disease |
| title | The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases |
| title_full | The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases |
| title_fullStr | The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases |
| title_full_unstemmed | The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases |
| title_short | The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases |
| title_sort | role of endogenous antimicrobial peptides in modulating innate immunity of the ocular surface in dry eye diseases |
| topic | ocular surface disease antimicrobial peptide innate immune system dry eye disease |
| url | https://www.mdpi.com/1422-0067/22/2/721 |
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