T-cell immunophenotyping in COVID-19 pneumonia

The COVID-19 epidemic is currently a global threat that has affected many parts of the world. Some patients require intensive care unit admission due to severe symptoms in the course of the disease. The severity of symptoms in this disease varies from person to person. The effectiveness of the immun...

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Main Authors: Pardis Nematollahi, Farzaneh Ashrafi, Ali Darakhshandeh, Mehrzad Salmasi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Journal of Research in Medical Sciences
Subjects:
Online Access:http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=81;epage=81;aulast=Nematollahi
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author Pardis Nematollahi
Farzaneh Ashrafi
Ali Darakhshandeh
Mehrzad Salmasi
author_facet Pardis Nematollahi
Farzaneh Ashrafi
Ali Darakhshandeh
Mehrzad Salmasi
author_sort Pardis Nematollahi
collection DOAJ
description The COVID-19 epidemic is currently a global threat that has affected many parts of the world. Some patients require intensive care unit admission due to severe symptoms in the course of the disease. The severity of symptoms in this disease varies from person to person. The effectiveness of the immune response against viral infections depends on the number and activity of T-cells, which play an important role in eliminating virus-infected cells. In this study, we report two patients with COVID-19 pneumonia, one with moderate symptoms and the other with severe symptoms. Although a decrease of absolute lymphocyte count was seen in both patients, a more significant decline reported in the ICU-admitted patient. Expression of activated markers, HLA-DR, CD38, on CD8-positive T-cells was shown in a patient with more severe disease. On the other hand, partial loss of CD7 in the severe case was also observed. Hence, besides of the above parameters that already mentioned in other studies, loss of pan T-markers could be considered as a potentially valuable test for predicting disease severity. We suggest evaluating the predictability of these tests in COVID-19 in larger studies. This study was approved by the Ethics Committee of Isfahan University of Medical Sciences (IR.MUI.MED.REC.1399.238).
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spelling doaj.art-323c1457429f4882a9f290a7b2b2f89c2022-12-21T19:52:56ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362021-01-01261818110.4103/jrms.JRMS_598_20T-cell immunophenotyping in COVID-19 pneumoniaPardis NematollahiFarzaneh AshrafiAli DarakhshandehMehrzad SalmasiThe COVID-19 epidemic is currently a global threat that has affected many parts of the world. Some patients require intensive care unit admission due to severe symptoms in the course of the disease. The severity of symptoms in this disease varies from person to person. The effectiveness of the immune response against viral infections depends on the number and activity of T-cells, which play an important role in eliminating virus-infected cells. In this study, we report two patients with COVID-19 pneumonia, one with moderate symptoms and the other with severe symptoms. Although a decrease of absolute lymphocyte count was seen in both patients, a more significant decline reported in the ICU-admitted patient. Expression of activated markers, HLA-DR, CD38, on CD8-positive T-cells was shown in a patient with more severe disease. On the other hand, partial loss of CD7 in the severe case was also observed. Hence, besides of the above parameters that already mentioned in other studies, loss of pan T-markers could be considered as a potentially valuable test for predicting disease severity. We suggest evaluating the predictability of these tests in COVID-19 in larger studies. This study was approved by the Ethics Committee of Isfahan University of Medical Sciences (IR.MUI.MED.REC.1399.238).http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=81;epage=81;aulast=Nematollahicovid-19flowcytometryt cell immunophenotyping
spellingShingle Pardis Nematollahi
Farzaneh Ashrafi
Ali Darakhshandeh
Mehrzad Salmasi
T-cell immunophenotyping in COVID-19 pneumonia
Journal of Research in Medical Sciences
covid-19
flowcytometry
t cell immunophenotyping
title T-cell immunophenotyping in COVID-19 pneumonia
title_full T-cell immunophenotyping in COVID-19 pneumonia
title_fullStr T-cell immunophenotyping in COVID-19 pneumonia
title_full_unstemmed T-cell immunophenotyping in COVID-19 pneumonia
title_short T-cell immunophenotyping in COVID-19 pneumonia
title_sort t cell immunophenotyping in covid 19 pneumonia
topic covid-19
flowcytometry
t cell immunophenotyping
url http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=81;epage=81;aulast=Nematollahi
work_keys_str_mv AT pardisnematollahi tcellimmunophenotypingincovid19pneumonia
AT farzanehashrafi tcellimmunophenotypingincovid19pneumonia
AT alidarakhshandeh tcellimmunophenotypingincovid19pneumonia
AT mehrzadsalmasi tcellimmunophenotypingincovid19pneumonia