Summary: | A numerical investigation of a surface plasmon biosensor based on D-shaped microstructured optical fiber (MOF) with rectangular lattice is presented. A full-vector finite-element method is applied to analyze the resonance coupling properties. By adjusting the diameters of two large air holes, the proposed biosensor shows excellent performance. High sensitivity and narrow full-width at half-maximum (FWHM) can be achieved. In particular, the figure of merit can reach to 478.3RIU<sup>-1</sup>, which is to our knowledge the highest among the reported MOF sensors. In the last part, the influence of coating thickness on the sensing performance has been considered.
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